TopFIND 4.0

P08473: Neprilysin

General Information

Protein names
- Neprilysin
- 3.4.24.11 {ECO:0000269|PubMed:15283675, ECO:0000269|PubMed:27588448, ECO:0000269|PubMed:8168535}
- Atriopeptidase
- Common acute lymphocytic leukemia antigen
- CALLA
- Enkephalinase
- Neutral endopeptidase 24.11
- NEP
- Neutral endopeptidase
- Skin fibroblast elastase
- SFE
- CD10
Gene names MME
Organism Homo sapiens
Protease Family M13.001
Protease ID M13.001
Chromosome location
UniProt ID P08473

1

N-termini

5

C-termini

0

Cleavages

104

Substrates

Sequence

        10         20         30         40         50         60 
MGKSESQMDI TDINTPKPKK KQRWTPLEIS LSVLVLLLTI IAVTMIALYA TYDDGICKSS 
        70         80         90        100        110        120 
DCIKSAARLI QNMDATTEPC TDFFKYACGG WLKRNVIPET SSRYGNFDIL RDELEVVLKD 
       130        140        150        160        170        180 
VLQEPKTEDI VAVQKAKALY RSCINESAID SRGGEPLLKL LPDIYGWPVA TENWEQKYGA 
       190        200        210        220        230        240 
SWTAEKAIAQ LNSKYGKKVL INLFVGTDDK NSVNHVIHID QPRLGLPSRD YYECTGIYKE 
       250        260        270        280        290        300 
ACTAYVDFMI SVARLIRQEE RLPIDENQLA LEMNKVMELE KEIANATAKP EDRNDPMLLY 
       310        320        330        340        350        360 
NKMTLAQIQN NFSLEINGKP FSWLNFTNEI MSTVNISITN EEDVVVYAPE YLTKLKPILT 
       370        380        390        400        410        420 
KYSARDLQNL MSWRFIMDLV SSLSRTYKES RNAFRKALYG TTSETATWRR CANYVNGNME 
       430        440        450        460        470        480 
NAVGRLYVEA AFAGESKHVV EDLIAQIREV FIQTLDDLTW MDAETKKRAE EKALAIKERI 
       490        500        510        520        530        540 
GYPDDIVSND NKLNNEYLEL NYKEDEYFEN IIQNLKFSQS KQLKKLREKV DKDEWISGAA 
       550        560        570        580        590        600 
VVNAFYSSGR NQIVFPAGIL QPPFFSAQQS NSLNYGGIGM VIGHEITHGF DDNGRNFNKD 
       610        620        630        640        650        660 
GDLVDWWTQQ SASNFKEQSQ CMVYQYGNFS WDLAGGQHLN GINTLGENIA DNGGLGQAYR 
       670        680        690        700        710        720 
AYQNYIKKNG EEKLLPGLDL NHKQLFFLNF AQVWCGTYRP EYAVNSIKTD VHSPGNFRII 
       730        740        750    
GTLQNSAEFS EAFHCRKNSY MNPEKKCRVW 

Isoforms



Sequence View



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Protein Neighborhood

Domains & Features

1 N-termini - 5 C-termini - 0 Cleavages - 104 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    P08473-2-unknown GKSESQ... 2 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

C-termini

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates