TopFIND 4.0

P01148: Progonadoliberin-1

General Information

Protein names	- Progonadoliberin-1 - Progonadoliberin I - Gonadoliberin-1 - Gonadoliberin I - Gonadorelin - Gonadotropin-releasing hormone I - GnRH-I - Luliberin I - Luteinizing hormone-releasing hormone I - LH-RH I - GnRH-associated peptide 1 - GnRH-associated peptide I
Gene names	GNRH1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P01148

9

N-termini

9

C-termini

15

Cleavages

0

Substrates

Sequence

10 20 30 40 50 60
MKPIQKLLAG LILLTWCVEG CSSQHWSYGL RPGGKRDAEN LIDSFQEIVK EVGQLAETQR
70 80 90
FECTTHQPRS PLRDLKGALE SLIEEETGQK KI

Isoforms

Sequence View

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

9 N-termini - 9 C-termini - 15 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P01148-24-Pyrrolidone carboxylic acid	QHWSYG...	24	pyrrolidone carboxylic acid-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P01148-26-unknown	WSYGLR...	26		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC31684
P01148-27-unknown	SYGLRP...	27		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC27398
P01148-27-unknown	SYGLRP...	27		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16996
P01148-28-unknown	YGLRPG...	28		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26675
P01148-28-unknown	YGLRPG...	28		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16997
P01148-29-unknown	GLRPGG...	29		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16998
P01148-30-unknown	LRPGGK...	30		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16
P01148-30-unknown	LRPGGK...	30		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26676
P01148-30-unknown	LRPGGK...	30		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC867
P01148-30-unknown	LRPGGK...	30		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16999
P01148-30-unknown	LRPGGK...	30		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19899
P01148-30-unknown	LRPGGK...	30		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC721
P01148-31-unknown	RPGGKR...	31		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17000
P01148-33-unknown	GGKRDA...	33		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC27620
P01148-37-unknown	DAENLI...	37		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26544

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...CSSQHW	25	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC31684
	...SSQHWS	26	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC27398
	...SSQHWS	26	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16996
	...SQHWSY	27	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26675
	...SQHWSY	27	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16997
	...QHWSYG	28	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16998
	...HWSYGL	29	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16
	...HWSYGL	29	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26676
	...HWSYGL	29	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC867
	...HWSYGL	29	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16999
	...HWSYGL	29	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19899
	...HWSYGL	29	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC721
	...WSYGLR	30	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17000
	...YGLRPG	32	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC27620
	...PGGKRD	36	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26544
	...GQKKI	92	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
THOP1_HUMAN	25	SQHW.\|.WSYG	inferred from experiment	unknown	MEROPS	Barrett AJ	Dando PM et al.:Human thimet oligopeptidase.... (M03.001)	8373360,
PGPI_HUMAN	26	QHWS.\|.SYGL	inferred from experiment	unknown	MEROPS	Casis L	De Gandarias JM et al.:Developmental changes of pyrogl... (C15.010)	7989161,
MEP1A_HUMAN	26	QHWS.\|.SYGL	inferred from experiment	unknown	MEROPS	Bond JS	Bertenshaw GP et al.:Marked differences between meta... (M12.002)	11278902,
NEP_HUMAN	27	HWSY.\|.YGLR	inferred from experiment	unknown	MEROPS	Ouimet T	Rose C et al.:Cell-specific activity of nepri... (M13.008)	11964170,
MEP1A_HUMAN	27	HWSY.\|.YGLR	inferred from experiment	unknown	MEROPS	Bond JS	Bertenshaw GP et al.:Marked differences between meta... (M12.002)	11278902,
MEP1A_HUMAN	28	WSYG.\|.GLRP	inferred from experiment	unknown	MEROPS	Bond JS	Bertenshaw GP et al.:Marked differences between meta... (M12.002)	11278902,
ACE_HUMAN	29	SYGL.\|.LRPG	inferred from experiment	unknown	MEROPS	Erdos EG	Skidgel RA et al.:Novel activity of human angiote... (M02.001)	2983326,
NEP_HUMAN	29	SYGL.\|.LRPG	inferred from experiment	unknown	MEROPS	Ouimet T	Rose C et al.:Cell-specific activity of nepri... (M13.008)	11964170,
CAN2_HUMAN	29	SYGL.\|.LRPG	inferred from experiment	unknown	MEROPS	Pennington RJ	McDermott JR et al.:Specificity of neuropeptide deg... (C02.001)	2410757,
MEP1A_HUMAN	29	SYGL.\|.LRPG	inferred from experiment	unknown	MEROPS	Bond JS	Bertenshaw GP et al.:Marked differences between meta... (M12.002)	11278902,
MMEL1_HUMAN	29	SYGL.\|.LRPG	inferred from experiment	unknown	MEROPS	Ouimet T	Rose C et al.:Cell-specific activity of nepri... (M13.008)	11964170,
CAN1_HUMAN	29	SYGL.\|.LRPG	inferred from experiment	unknown	MEROPS	Pennington RJ	McDermott JR et al.:Specificity of neuropeptide deg... (C02.001)	2410757,
MEP1A_HUMAN	30	YGLR.\|.RPGG	inferred from experiment	unknown	MEROPS	Bond JS	Bertenshaw GP et al.:Marked differences between meta... (M12.002)	11278902,
PPCE_HUMAN	32	LRPG.\|.GGKR	inferred from experiment	unknown	MEROPS	Smith AI	Lew RA et al.:Evidence for a two-step mechani... (S09.001)	8175672,
NEC2_HUMAN	36	GKRD.\|.DAEN	inferred from experiment	unknown	MEROPS	Chretien M	Seidah NG et al.:Pro-protein convertases of subt... (S08.072)	7845206,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)