P48147: Prolyl endopeptidase

General Information

Protein names	- Prolyl endopeptidase - PE - 3.4.21.26 - Post-proline cleaving enzyme
Gene names	PREP
Organism	Homo sapiens
Protease Family	S09.001
Protease ID	S09.001
Chromosome location
UniProt ID	P48147

8 N-termini

8 C-termini

7 Cleavages

18 Substrates

Sequence

        10         20         30         40         50         60
MLSLQYPDVY RDETAVQDYH GHKICDPYAW LEDPDSEQTK AFVEAQNKIT VPFLEQCPIR
        70         80         90        100        110        120
GLYKERMTEL YDYPKYSCHF KKGKRYFYFY NTGLQNQRVL YVQDSLEGEA RVFLDPNILS
       130        140        150        160        170        180
DDGTVALRGY AFSEDGEYFA YGLSASGSDW VTIKFMKVDG AKELPDVLER VKFSCMAWTH
       190        200        210        220        230        240
DGKGMFYNSY PQQDGKSDGT ETSTNLHQKL YYHVLGTDQS EDILCAEFPD EPKWMGGAEL
       250        260        270        280        290        300
SDDGRYVLLS IREGCDPVNR LWYCDLQQES SGIAGILKWV KLIDNFEGEY DYVTNEGTVF
       310        320        330        340        350        360
TFKTNRQSPN YRVINIDFRD PEESKWKVLV PEHEKDVLEW IACVRSNFLV LCYLHDVKNI
       370        380        390        400        410        420
LQLHDLTTGA LLKTFPLDVG SIVGYSGQKK DTEIFYQFTS FLSPGIIYHC DLTKEELEPR
       430        440        450        460        470        480
VFREVTVKGI DASDYQTVQI FYPSKDGTKI PMFIVHKKGI KLDGSHPAFL YGYGGFNISI
       490        500        510        520        530        540
TPNYSVSRLI FVRHMGGILA VANIRGGGEY GETWHKGGIL ANKQNCFDDF QCAAEYLIKE
       550        560        570        580        590        600
GYTSPKRLTI NGGSNGGLLV AACANQRPDL FGCVIAQVGV MDMLKFHKYT IGHAWTTDYG
       610        620        630        640        650        660
CSDSKQHFEW LVKYSPLHNV KLPEADDIQY PSMLLLTADH DDRVVPLHSL KFIATLQYIV
       670        680        690        700        710
GRSRKQSNPL LIHVDTKAGH GAGKPTAKVI EEVSDMFAFI ARCLNVDWIP

Isoforms

Sequence View

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P48147-1-Acetylation	MLSLQY...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P48147-1-Acetylation	MLSLQY...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P48147-1-Acetylation	MLSLQY...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P48147-1-Acetylation	MLSLQY...	1	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P48147-13-unknown	ETAVQD...	13		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2561
P48147-36-unknown	SEQTKA...	36		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2562
P48147-116-unknown	PNILSD...	116		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2563
P48147-268-unknown	QESSGI...	268		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7482
P48147-292-unknown	YVTNEG...	292		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2564
P48147-337-unknown	VLEWIA...	337		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2565
P48147-627-unknown	DIQYPS...	627		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2566

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DVYRDE	12	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2561
...LEDPDS	35	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2562
...RVFLDP	115	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2563
...YCDLQQ	267	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7482
...EGEYDY	291	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2564
...EHEKDV	336	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2565
...LPEADD	626	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2566
...VDWIP	710	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP6_HUMAN	12	YRDE.\|.ETAV	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,
CASP6_HUMAN	35	DPDS.\|.SEQT	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,
CASP6_HUMAN	115	FLDP.\|.PNIL	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,
CATS_HUMAN	267	DLQQ.\|.QESS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CASP6_HUMAN	291	EYDY.\|.YVTN	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,
CASP6_HUMAN	336	EKDV.\|.VLEW	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,
CASP6_HUMAN	626	EADD.\|.DIQY	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
TYB4_HUMAN	5	DKPD.\|.DMAE	inferred from experiment	unknown	MEROPS	Carretero OA	Cavasin MA et al.:Prolyl oligopeptidase is involv... (S09.001)	15037553,
NEU1_HUMAN	26	NCPL.\|.LGGK	inferred from experiment	unknown	MEROPS	Walter R	Koida M et al.:Post-proline cleaving enzyme. P... (S09.001)	12173,
GON1_HUMAN	32	LRPG.\|.GGKR	inferred from experiment	unknown	MEROPS	Smith AI	Lew RA et al.:Evidence for a two-step mechani... (S09.001)	8175672,
ANGT_HUMAN	40	IHPF.\|.FHLV	inferred from experiment	unknown	MEROPS	Walter R	Koida M et al.:Post-proline cleaving enzyme. P... (S09.001)	12173,
TKN1_HUMAN	61	PKPQ.\|.QQFF	inferred from experiment	unknown	MEROPS	Syed SA	Makinen PL et al.:Role of the chymotrypsin-like m... (S09.001)	7543886,
TKN1-Isoform4_HUMAN	61	PKPQ.\|.QQFF	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27623
TKN1-Isoform3_HUMAN	61	PKPQ.\|.QQFF	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27623
TKN1-Isoform2_HUMAN	61	PKPQ.\|.QQFF	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27623
COLI_HUMAN	149	GKPV.\|.VGKK	inferred from experiment	unknown	MEROPS		Merops PPCE_HUMAN -> COLI_HUMAN @149
KNG1-Isoform3_HUMAN	346	KRPP.\|.PGFS	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27611
KNG1-Isoform3_HUMAN	347	RPPG.\|.GFSP	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27614
KNG1-Isoform3_HUMAN	351	FSPF.\|.FRSS	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27617
KNG1_HUMAN	382	KRPP.\|.PGFS	inferred from experiment	unknown	MEROPS		Merops PPCE_HUMAN -> KNG1_HUMAN @382
KNG1-Isoform2_HUMAN	382	KRPP.\|.PGFS	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27611
KNG1_HUMAN	383	RPPG.\|.GFSP	inferred from experiment	unknown	MEROPS	Walter R	Koida M et al.:Post-proline cleaving enzyme. P... (S09.001)	12173,
KNG1-Isoform2_HUMAN	383	RPPG.\|.GFSP	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27614
KNG1_HUMAN	387	FSPF.\|.FRSS	inferred from experiment	unknown	MEROPS	Syed SA	Makinen PL et al.:Role of the chymotrypsin-like m... (S09.001)	7543886,
KNG1-Isoform2_HUMAN	387	FSPF.\|.FRSS	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27617

TopFIND

P48147: Prolyl endopeptidase

General Information

8

N-termini

8

C-termini

7

Cleavages

18

Substrates

Sequence

Isoforms

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Protein Neighborhood

Domains & Features

8 N-termini - 8 C-termini - 7 Cleavages - 18 Substrates

N-termini

C-termini

Cleavages

Substrates