TopFIND 4.0

P62328: Thymosin beta-4

General Information

Protein names	- Thymosin beta-4 - T beta-4 - Fx - Hematopoietic system regulatory peptide - Seraspenide
Gene names	TMSB4X
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P62328

12

N-termini

6

C-termini

5

Cleavages

0

Substrates

Sequence

10 20 30 40
MSDKPDMAEI EKFDKSKLKK TETQEKNPLP SKETIEQEKQ AGES

Isoforms

Sequence View

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Protease Assignment Confidence:

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Protein Neighborhood

Domains & Features

12 N-termini - 6 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P62328-1-unknown	MSDKPD...	1			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P62328-2-unknown	MSDKPD...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P62328-2-Acetylation	SDKPDM...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P62328-6-unknown	DMAEIE...	6		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC27627
P62328-6-unknown	DMAEIE...	6		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P62328-6-unknown	DMAEIE...	6		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P62328-7-	MAEIEK...	7			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P62328-7-	MAEIEK...	7			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P62328-7-	MAEIEK...	7			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P62328-7-unknown	MAEIEK...	7		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17786
P62328-21-	TETQEK...	21			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P62328-21-	TETQEK...	21			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P62328-21-	TETQEK...	21			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P62328-21-unknown	TETQEK...	21			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P62328-23-unknown	TQEKNP...	23		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17787
P62328-26-unknown	KNPLPS...	26		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17788
P62328-27-	NPLPSK...	27			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P62328-27-	NPLPSK...	27			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P62328-27-unknown	NPLPSK...	27		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17789

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...MSDKPD	5	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC27627
	...SDKPDM	6	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17786
	...LKKTET	22	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17787
	...TETQEK	25	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17788
	...ETQEKN	26	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17789
	...QAGES	44	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
PPCE_HUMAN	5	DKPD.\|.DMAE	inferred from experiment	unknown	MEROPS	Carretero OA	Cavasin MA et al.:Prolyl oligopeptidase is involv... (S09.001)	15037553,
MEP1A_HUMAN	6	KPDM.\|.MAEI	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	22	KTET.\|.TQEK	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	25	TQEK.\|.KNPL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	26	QEKN.\|.NPLP	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)