P01189: Pro-opiomelanocortin

General Information

Protein names	- Pro-opiomelanocortin - POMC - Corticotropin-lipotropin - NPP - Melanotropin gamma - Gamma-MSH - Potential peptide - Corticotropin - Adrenocorticotropic hormone - ACTH - Melanocyte-stimulating hormone alpha - Alpha-MSH - Melanotropin alpha - Corticotropin-like intermediary peptide - CLIP - Lipotropin beta - Beta-LPH - Lipotropin gamma - Gamma-LPH - Melanocyte-stimulating hormone beta - Beta-MSH - Melanotropin beta - Beta-endorphin - Met-enkephalin
Gene names	POMC
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P01189

28 N-termini

28 C-termini

58 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPRSCCSRSG ALLLALLLQA SMEVRGWCLE SSQCQDLTTE SNLLECIRAC KPDLSAETPM
        70         80         90        100        110        120
FPGNGDEQPL TENPRKYVMG HFRWDRFGRR NSSSSGSSGA GQKREDVSAG EDCGPLPEGG
       130        140        150        160        170        180
PEPRSDGAKP GPREGKRSYS MEHFRWGKPV GKKRRPVKVY PNGAEDESAE AFPLEFKREL
       190        200        210        220        230        240
TGQRLREGDG PDGPADDGAG AQADLEHSLL VAAEKKDEGP YRMEHFRWGS PPKDKRYGGF
       250        260
MTSEKSQTPL VTLFKNAIIK NAYKKGE

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

28 N-termini - 28 C-termini - 58 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P01189-138-	SYSMEH...	138		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P01189-138-	SYSMEH...	138		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P01189-139-unknown	YSMEHF...	139	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC39
P01189-139-unknown	YSMEHF...	139	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26685
P01189-139-unknown	YSMEHF...	139	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P01189-139-unknown	YSMEHF...	139	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P01189-141-unknown	MEHFRW...	141	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17001
P01189-142-unknown	EHFRWG...	142	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26686
P01189-142-unknown	EHFRWG...	142	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17002
P01189-143-unknown	HFRWGK...	143	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8460
P01189-143-unknown	HFRWGK...	143	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26687
P01189-144-unknown	FRWGKP...	144	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26688
P01189-145-unknown	RWGKPV...	145	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8472
P01189-145-unknown	RWGKPV...	145	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26689
P01189-146-unknown	WGKPVG...	146	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26690
P01189-147-unknown	GKPVGK...	147	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26691
P01189-147-unknown	GKPVGK...	147	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17003
P01189-148-unknown	KPVGKK...	148	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17004
P01189-150-unknown	VGKKRR...	150	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26692
P01189-150-unknown	VGKKRR...	150	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC27622
P01189-155-unknown	RPVKVY...	155	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26693
P01189-156-unknown	PVKVYP...	156	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26962
P01189-156-unknown	PVKVYP...	156	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC27258
P01189-156-unknown	PVKVYP...	156	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26545
P01189-156-unknown	PVKVYP...	156	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26817
P01189-156-unknown	PVKVYP...	156	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9683
P01189-156-unknown	PVKVYP...	156	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC27109
P01189-157-unknown	VKVYPN...	157	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26694
P01189-159-unknown	VYPNGA...	159	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26695
P01189-163-unknown	GAEDES...	163	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26696
P01189-179-unknown	ELTGQR...	179	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26963
P01189-179-unknown	ELTGQR...	179	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC27259
P01189-179-unknown	ELTGQR...	179	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26546
P01189-179-unknown	ELTGQR...	179	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26818
P01189-179-unknown	ELTGQR...	179	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9684
P01189-179-unknown	ELTGQR...	179	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC27110
P01189-219-unknown	GPYRME...	219	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8477
P01189-219-unknown	GPYRME...	219	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4309
P01189-221-unknown	YRMEHF...	221	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8478
P01189-221-unknown	YRMEHF...	221	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4310
P01189-237-unknown	YGGFMT...	237	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26964
P01189-237-unknown	YGGFMT...	237	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC27260
P01189-237-unknown	YGGFMT...	237	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26547
P01189-237-unknown	YGGFMT...	237	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26819
P01189-237-unknown	YGGFMT...	237	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9685
P01189-237-unknown	YGGFMT...	237	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC224
P01189-237-unknown	YGGFMT...	237	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC27111
P01189-238-unknown	GGFMTS...	238	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16771
P01189-238-unknown	GGFMTS...	238	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC27810
P01189-238-unknown	GGFMTS...	238	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC245
P01189-240-unknown	FMTSEK...	240	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3331
P01189-240-unknown	FMTSEK...	240	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC31893
P01189-240-unknown	FMTSEK...	240	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC27637
P01189-241-unknown	MTSEKS...	241	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC27638
P01189-252-unknown	TLFKNA...	252	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC27639
P01189-253-unknown	LFKNAI...	253	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC27640
P01189-254-unknown	FKNAII...	254	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4644
P01189-254-unknown	FKNAII...	254	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4338
P01189-254-unknown	FKNAII...	254	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15604
P01189-254-unknown	FKNAII...	254	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC27641
P01189-255-unknown	KNAIIK...	255	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15605
P01189-258-unknown	IIKNAY...	258	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC27642

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EGKRSY	138	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC39
...EGKRSY	138	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26685
...KRSYSM	140	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17001
...RSYSME	141	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26686
...RSYSME	141	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17002
...SYSMEH	142	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8460
...SYSMEH	142	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26687
...YSMEHF	143	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26688
...SMEHFR	144	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8472
...SMEHFR	144	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26689
...MEHFRW	145	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26690
...EHFRWG	146	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26691
...EHFRWG	146	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17003
...HFRWGK	147	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17004
...RWGKPV	149	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26692
...RWGKPV	149	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27622
...VGKKRR	154	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26693
...GKKRRP	155	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26962
...GKKRRP	155	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27258
...GKKRRP	155	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26545
...GKKRRP	155	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26817
...GKKRRP	155	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9683
...GKKRRP	155	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27109
...KKRRPV	156	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26694
...RRPVKV	158	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26695
...KVYPNG	162	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26696
...LEFKRE	178	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26963
...LEFKRE	178	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27259
...LEFKRE	178	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26546
...LEFKRE	178	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26818
...LEFKRE	178	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9684
...LEFKRE	178	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27110
...EKKDEG	218	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8477
...EKKDEG	218	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4309
...KDEGPY	220	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8478
...KDEGPY	220	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4310
...PKDKRY	236	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26964
...PKDKRY	236	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27260
...PKDKRY	236	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26547
...PKDKRY	236	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26819
...PKDKRY	236	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9685
...PKDKRY	236	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC224
...PKDKRY	236	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27111
...KDKRYG	237	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16771
...KDKRYG	237	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27810
...KDKRYG	237	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC245
...KRYGGF	239	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3331
...KRYGGF	239	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31893
...KRYGGF	239	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27637
...RYGGFM	240	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27638
...TSEKSQ	246	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000387993
...QTPLVT	251	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27639
...TPLVTL	252	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27640
...PLVTLF	253	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4644
...PLVTLF	253	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4338
...PLVTLF	253	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15604
...PLVTLF	253	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27641
...LVTLFK	254	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15605
...LFKNAI	257	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27642

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
ACPH_HUMAN	138	KRSY.\|.YSME	inferred from experiment	unknown	MEROPS		Merops ACPH_HUMAN -> COLI_HUMAN @138
NEP_HUMAN	138	KRSY.\|.YSME	inferred from experiment	unknown	MEROPS	Luger TA	Scholzen TE et al.:Terminating the stress: periphe... (M13.001)	17363457,
MEP1A_HUMAN	140	SYSM.\|.MEHF	inferred from experiment	unknown	MEROPS	Bond JS	Bylander JE et al.:Human and mouse homo-oligomeric... (M12.002)	17976009,
NEP_HUMAN	141	YSME.\|.EHFR	inferred from experiment	unknown	MEROPS	Luger TA	Scholzen TE et al.:Terminating the stress: periphe... (M13.001)	17363457,
MEP1A_HUMAN	141	YSME.\|.EHFR	inferred from experiment	unknown	MEROPS	Bond JS	Bylander JE et al.:Human and mouse homo-oligomeric... (M12.002)	17976009,
DNPEP_HUMAN	142	SMEH.\|.HFRW	inferred from experiment	unknown	MEROPS	Neidle A	Kelly JA et al.:An aminopeptidase from mouse br... (M18.002)	6854330,
NEP_HUMAN	142	SMEH.\|.HFRW	inferred from experiment	unknown	MEROPS	Luger TA	Scholzen TE et al.:Terminating the stress: periphe... (M13.001)	17363457,
NEP_HUMAN	143	MEHF.\|.FRWG	inferred from experiment	unknown	MEROPS	Luger TA	Scholzen TE et al.:Terminating the stress: periphe... (M13.001)	17363457,
DPP3_HUMAN	144	EHFR.\|.RWGK	inferred from experiment	unknown	MEROPS		Merops DPP3_HUMAN -> COLI_HUMAN @144
NEP_HUMAN	144	EHFR.\|.RWGK	inferred from experiment	unknown	MEROPS	Luger TA	Scholzen TE et al.:Terminating the stress: periphe... (M13.001)	17363457,
NEP_HUMAN	145	HFRW.\|.WGKP	inferred from experiment	unknown	MEROPS	Luger TA	Scholzen TE et al.:Terminating the stress: periphe... (M13.001)	17363457,
NEP_HUMAN	146	FRWG.\|.GKPV	inferred from experiment	unknown	MEROPS	Luger TA	Scholzen TE et al.:Terminating the stress: periphe... (M13.001)	17363457,
MEP1A_HUMAN	146	FRWG.\|.GKPV	inferred from experiment	unknown	MEROPS	Bond JS	Bylander JE et al.:Human and mouse homo-oligomeric... (M12.002)	17976009,
MEP1A_HUMAN	147	RWGK.\|.KPVG	inferred from experiment	unknown	MEROPS	Bond JS	Bertenshaw GP et al.:Marked differences between meta... (M12.002)	11278902,
NEP_HUMAN	149	GKPV.\|.VGKK	inferred from experiment	unknown	MEROPS	Luger TA	Scholzen TE et al.:Terminating the stress: periphe... (M13.001)	17363457,
PPCE_HUMAN	149	GKPV.\|.VGKK	inferred from experiment	unknown	MEROPS		Merops PPCE_HUMAN -> COLI_HUMAN @149
NEP_HUMAN	154	KKRR.\|.RPVK	inferred from experiment	unknown	MEROPS	Luger TA	Scholzen TE et al.:Terminating the stress: periphe... (M13.001)	17363457,
PCSK5_HUMAN	155	KRRP.\|.PVKV	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK7_HUMAN	155	KRRP.\|.PVKV	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
NEC2_HUMAN	155	KRRP.\|.PVKV	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK4_HUMAN	155	KRRP.\|.PVKV	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
FURIN_HUMAN	155	KRRP.\|.PVKV	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK6_HUMAN	155	KRRP.\|.PVKV	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
NEP_HUMAN	156	RRPV.\|.VKVY	inferred from experiment	unknown	MEROPS	Luger TA	Scholzen TE et al.:Terminating the stress: periphe... (M13.001)	17363457,
NEP_HUMAN	158	PVKV.\|.VYPN	inferred from experiment	unknown	MEROPS	Luger TA	Scholzen TE et al.:Terminating the stress: periphe... (M13.001)	17363457,
NEP_HUMAN	162	YPNG.\|.GAED	inferred from experiment	unknown	MEROPS	Luger TA	Scholzen TE et al.:Terminating the stress: periphe... (M13.001)	17363457,
PCSK5_HUMAN	178	FKRE.\|.ELTG	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK7_HUMAN	178	FKRE.\|.ELTG	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
NEC2_HUMAN	178	FKRE.\|.ELTG	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK4_HUMAN	178	FKRE.\|.ELTG	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
FURIN_HUMAN	178	FKRE.\|.ELTG	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK6_HUMAN	178	FKRE.\|.ELTG	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
DPP4_HUMAN	218	KDEG.\|.GPYR	inferred from experiment	unknown	MEROPS	Smith DP	Hsiung HM et al.:Potent peptide agonists for hum... (C01.070)	15985311,
CATC_HUMAN	218	KDEG.\|.GPYR	inferred from experiment	unknown	MEROPS	Smith DP	Hsiung HM et al.:Potent peptide agonists for hum... (C01.070)	15985311,
DPP4_HUMAN	220	EGPY.\|.YRME	inferred from experiment	unknown	MEROPS	Smith DP	Hsiung HM et al.:Potent peptide agonists for hum... (C01.070)	15985311,
CATC_HUMAN	220	EGPY.\|.YRME	inferred from experiment	unknown	MEROPS	Smith DP	Hsiung HM et al.:Potent peptide agonists for hum... (C01.070)	15985311,
PCSK5_HUMAN	236	DKRY.\|.YGGF	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK7_HUMAN	236	DKRY.\|.YGGF	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
NEC2_HUMAN	236	DKRY.\|.YGGF	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK4_HUMAN	236	DKRY.\|.YGGF	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
FURIN_HUMAN	236	DKRY.\|.YGGF	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
AMPB_HUMAN	236	DKRY.\|.YGGF	inferred from experiment	unknown	MEROPS		Merops AMPB_HUMAN -> COLI_HUMAN @236
PCSK6_HUMAN	236	DKRY.\|.YGGF	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
LKHA4_HUMAN	237	KRYG.\|.GGFM	inferred from experiment	unknown	MEROPS	Fitzpatrick FA	Griffin KJ et al.:Opioid peptides are substrates ... (M01.004)	1410529,
PSA_HUMAN	237	KRYG.\|.GGFM	inferred from experiment	unknown	MEROPS		Merops PSA_HUMAN -> COLI_HUMAN @237
AMPN_HUMAN	237	KRYG.\|.GGFM	inferred from experiment	unknown	MEROPS		Merops AMPN_HUMAN -> COLI_HUMAN @237
CATB_HUMAN	239	YGGF.\|.FMTS	inferred from experiment	unknown	MEROPS	Tang J	Takahashi T et al.:Porcine spleen cathepsin B is a... (C01.060)	3522589,
TPP1_HUMAN	239	YGGF.\|.FMTS	inferred from experiment	unknown	MEROPS	Oda K	Oyama H et al.:Catalytic residues and substrat... (S53.003)	16091586,
PREP_HUMAN	239	YGGF.\|.FMTS	inferred from experiment	unknown	MEROPS	Hersh LB	Chow KM et al.:Mammalian pitrilysin: substrate... (M16.009)	19196155,
PREP_HUMAN	240	GGFM.\|.MTSE	inferred from experiment	unknown	MEROPS	Hersh LB	Chow KM et al.:Mammalian pitrilysin: substrate... (M16.009)	19196155,
PREP_HUMAN	251	PLVT.\|.TLFK	inferred from experiment	unknown	MEROPS	Hersh LB	Chow KM et al.:Mammalian pitrilysin: substrate... (M16.009)	19196155,
PREP_HUMAN	252	LVTL.\|.LFKN	inferred from experiment	unknown	MEROPS	Hersh LB	Chow KM et al.:Mammalian pitrilysin: substrate... (M16.009)	19196155,
CATE_HUMAN	253	VTLF.\|.FKNA	inferred from experiment	unknown	MEROPS	Yonezawa S	Kageyama T et al.:Processing of the precursors to... (A01.009)	7642580,
CATD_HUMAN	253	VTLF.\|.FKNA	inferred from experiment	unknown	MEROPS	Yonezawa S	Kageyama T et al.:Processing of the precursors to... (A01.009)	7642580,
IDE_HUMAN	253	VTLF.\|.FKNA	inferred from experiment	unknown	MEROPS	Kanaya S	Cornista J et al.:Cleavage of various peptides wi... (M16.002)	15502359,
PREP_HUMAN	253	VTLF.\|.FKNA	inferred from experiment	unknown	MEROPS	Hersh LB	Chow KM et al.:Mammalian pitrilysin: substrate... (M16.009)	19196155,
IDE_HUMAN	254	TLFK.\|.KNAI	inferred from experiment	unknown	MEROPS	Kanaya S	Cornista J et al.:Cleavage of various peptides wi... (M16.002)	15502359,
PREP_HUMAN	257	KNAI.\|.IIKN	inferred from experiment	unknown	MEROPS	Hersh LB	Chow KM et al.:Mammalian pitrilysin: substrate... (M16.009)	19196155,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)