P53634: Dipeptidyl peptidase 1

General Information

Protein names	- Dipeptidyl peptidase 1 - 3.4.14.1 - Cathepsin C - Cathepsin J - Dipeptidyl peptidase I - DPP-I - DPPI - Dipeptidyl transferase - Dipeptidyl peptidase 1 exclusion domain chain - Dipeptidyl peptidase I exclusion domain chain - Dipeptidyl peptidase 1 heavy chain - Dipeptidyl peptidase I heavy chain - Dipeptidyl peptidase 1 light chain - Dipeptidyl peptidase I light chain
Gene names	CTSC
Organism	Homo sapiens
Protease Family	C01.070
Protease ID	C01.070
Chromosome location
UniProt ID	P53634

14 N-termini

11 C-termini

8 Cleavages

9 Substrates

Sequence

Isoforms

- Isoform 2 of Dipeptidyl peptidase 1 - Isoform 3 of Dipeptidyl peptidase 1

Sequence View

        10         20         30         40         50         60
MGAGPSLLLA ALLLLLSGDG AVRCDTPANC TYLDLLGTWV FQVGSSGSQR DVNCSVMGPQ
        70         80         90        100        110        120
EKKVVVYLQK LDTAYDDLGN SGHFTIIYNQ GFEIVLNDYK WFAFFKYKEE GSKVTTYCNE
       130        140        150        160        170        180
TMTGWVHDVL GRNWACFTGK KVGTASENVY VNIAHLKNSQ EKYSNRLYKY DHNFVKAINA
       190        200        210        220        230        240
IQKSWTATTY MEYETLTLGD MIRRSGGHSR KIPRPKPAPL TAEIQQKILH LPTSWDWRNV
       250        260        270        280        290        300
HGINFVSPVR NQASCGSCYS FASMGMLEAR IRILTNNSQT PILSPQEVVS CSQYAQGCEG
       310        320        330        340        350        360
GFPYLIAGKY AQDFGLVEEA CFPYTGTDSP CKMKEDCFRY YSSEYHYVGG FYGGCNEALM
       370        380        390        400        410        420
KLELVHHGPM AVAFEVYDDF LHYKKGIYHH TGLRDPFNPF ELTNHAVLLV GYGTDSASGM
       430        440        450        460
DYWIVKNSWG TGWGENGYFR IRRGTDECAI ESIAVAATPI PKL         10         20         30         40         50         60
MGAGPSLLLA ALLLLLSGDG AVRCDTPANC TYLDLLGTWV FQVGSSGSQR DVNCSVMGPQ
        70         80         90        100        110        120
EKKVVVYLQK LDTAYDDLGN SGHFTIIYNQ GFEIVLNDYK WFAFFKYKEE GSKVTTYCNE
       130        140        150        160        170        180
TMTGWVHDVL GRNWACFTGK KVGTASENVY VNIAHLKNSQ EKYSNRLYKY DHNFVKAINA
       190        200        210        220        230        240
IQKSWTATTY MEYETLTLGD MIRRSGGHSR KIPRPKPAPL TAEIQQKILH LPTSWDWRNV
       250        260        270        280        290        300
HGINFVSPVR NQASCGSCYS FASMGMLEAR IRILTNNSQT PILSPQEVVS CSQYAQGCEG
       310        320        330        340        350        360
GFPYLIAGKY AQDFGLVEEA CFPYTGTDSP CKMKEDCFRY YSSEYHYVGG FYGGCNEALM
       370        380        390        400        410        420
KLELVHHGPM AVAFEVYDDF LHYKKGIYHH TGLRDPFNPF ELTNHAVLLV GYGTDSASGM
       430        440        450        460
DYWIVKNSWG TGWGENGYFR IRRGTDECAI ESIAVAATPI PKL

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

14 N-termini - 11 C-termini - 8 Cleavages - 9 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P53634-1-unknown	MGAGPS...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt69376
P53634-1-unknown	MGAGPS...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt69377
P53634-25-unknown	DTPANC...	25	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P53634-25-unknown	DTPANC...	25	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt113820
P53634-25-unknown	DTPANC...	25	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt113821
P53634-158-unknown	NSQEKY...	158	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6018
P53634-160-unknown	QEKYSN...	160	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4315
P53634-162-unknown	KYSNRL...	162	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4316
P53634-222-unknown	AEIQQK...	222	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6019
P53634-224-unknown	IQQKIL...	224	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4317
P53634-228-	ILHLPT...	228		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P53634-228-	ILHLPT...	228		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P53634-228-	ILHLPT...	228		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P53634-228-	ILHLPT...	228		Subtiligase Based Positive Selection		Wells	RMPI_untreated	23264352
P53634-228-	ILHLPT...	228		Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
P53634-228-unknown	ILHLPT...	228	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6020
P53634-228-unknown	ILHLPT...	228		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P53634-228-unknown	ILHLPT...	228		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P53634-229-	LHLPTS...	229		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P53634-229-	LHLPTS...	229		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P53634-229-	LHLPTS...	229		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P53634-229-	LHLPTS...	229		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P53634-229-unknown	LHLPTS...	229		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P53634-229-unknown	LHLPTS...	229		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P53634-230-	HLPTSW...	230		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P53634-231-unknown	LPTSWD...	231	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P53634-231-unknown	LPTSWD...	231	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6021
P53634-395-unknown	DPFNPF...	395	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P53634-395-unknown	DPFNPF...	395	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6022

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...LGRNWA	134	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...IAHLKN	157	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6018
...HLKNSQ	159	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4315
...KNSQEK	161	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4316
...PAPLTA	221	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6019
...PLTAEI	223	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4317
...EIQQKI	227	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6020
...QKILHL	230	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6021
...HTGLRD	394	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...HTGLRD	394	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6022
...PIPKL	463		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...PIPKL	463	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...PIPKL	463		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	157	HLKN.\|.NSQE	inferred from experiment	unknown	MEROPS	Turk B	Dahl SW et al.:Human recombinant pro-dipeptidy... (C01.070)	11327826,
CATC_HUMAN	159	KNSQ.\|.QEKY	inferred from experiment	unknown	MEROPS	Turk B	Dahl SW et al.:Human recombinant pro-dipeptidy... (C01.070)	11327826,
CATC_HUMAN	161	SQEK.\|.KYSN	inferred from experiment	unknown	MEROPS	Turk B	Dahl SW et al.:Human recombinant pro-dipeptidy... (C01.070)	11327826,
CATL1_HUMAN	221	PLTA.\|.AEIQ	inferred from experiment	unknown	MEROPS	Turk B	Dahl SW et al.:Human recombinant pro-dipeptidy... (C01.070)	11327826,
CATC_HUMAN	223	TAEI.\|.IQQK	inferred from experiment	unknown	MEROPS	Turk B	Dahl SW et al.:Human recombinant pro-dipeptidy... (C01.070)	11327826,
CATL1_HUMAN	227	QQKI.\|.ILHL	inferred from experiment	unknown	MEROPS	Turk B	Dahl SW et al.:Human recombinant pro-dipeptidy... (C01.070)	11327826,
CATL1_HUMAN	230	ILHL.\|.LPTS	inferred from experiment	unknown	MEROPS	Turk B	Dahl SW et al.:Human recombinant pro-dipeptidy... (C01.070)	11327826,
CATL1_HUMAN	394	GLRD.\|.DPFN	inferred from experiment	unknown	MEROPS	Turk B	Dahl SW et al.:Human recombinant pro-dipeptidy... (C01.070)	11327826,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	20	AGEI.\|.IIGG	inferred from experiment	unknown	MEROPS	Thiele DL	McGuire MJ et al.:Generation of active myeloid an... (C01.070)	8428921,
GRAA_HUMAN	28	CEKI.\|.IIGG	inferred from experiment	unknown	MEROPS	Thiele DL	McGuire MJ et al.:Generation of active myeloid an... (C01.070)	8428921,
ELNE_HUMAN	29	ASEI.\|.IVGG	inferred from experiment	unknown	MEROPS	Thiele DL	McGuire MJ et al.:Generation of active myeloid an... (C01.070)	8428921,
CCKN_HUMAN	100	MGWM.\|.MDFG	inferred from experiment	unknown	MEROPS	Warburton MJ	Bernardini F et al.:Lysosomal degradation of cholec... (C01.070)	12038963,
CATC_HUMAN	159	KNSQ.\|.QEKY	inferred from experiment	unknown	MEROPS	Turk B	Dahl SW et al.:Human recombinant pro-dipeptidy... (C01.070)	11327826,
CATC_HUMAN	161	SQEK.\|.KYSN	inferred from experiment	unknown	MEROPS	Turk B	Dahl SW et al.:Human recombinant pro-dipeptidy... (C01.070)	11327826,
COLI_HUMAN	218	KDEG.\|.GPYR	inferred from experiment	unknown	MEROPS	Smith DP	Hsiung HM et al.:Potent peptide agonists for hum... (C01.070)	15985311,
COLI_HUMAN	220	EGPY.\|.YRME	inferred from experiment	unknown	MEROPS	Smith DP	Hsiung HM et al.:Potent peptide agonists for hum... (C01.070)	15985311,
CATC_HUMAN	223	TAEI.\|.IQQK	inferred from experiment	unknown	MEROPS	Turk B	Dahl SW et al.:Human recombinant pro-dipeptidy... (C01.070)	11327826,