Q9ULA0: Aspartyl aminopeptidase

General Information

Protein names	- Aspartyl aminopeptidase - 3.4.11.21
Gene names	DNPEP
Organism	Homo sapiens
Protease Family	M18.002
Protease ID	M18.002
Chromosome location
UniProt ID	Q9ULA0

3 N-termini

7 C-termini

0 Cleavages

2 Substrates

Sequence

        10         20         30         40         50         60
MQVAMNGKAR KEAVQTAAKE LLKFVNRSPS PFHAVAECRN RLLQAGFSEL KETEKWNIKP
        70         80         90        100        110        120
ESKYFMTRNS STIIAFAVGG QYVPGNGFSL IGAHTDSPCL RVKRRSRRSQ VGFQQVGVET
       130        140        150        160        170        180
YGGGIWSTWF DRDLTLAGRV IVKCPTSGRL EQQLVHVERP ILRIPHLAIH LQRNINENFG
       190        200        210        220        230        240
PNTEMHLVPI LATAIQEELE KGTPEPGPLN AVDERHHSVL MSLLCAHLGL SPKDIVEMEL
       250        260        270        280        290        300
CLADTQPAVL GGAYDEFIFA PRLDNLHSCF CALQALIDSC AGPGSLATEP HVRMVTLYDN
       310        320        330        340        350        360
EEVGSESAQG AQSLLTELVL RRISASCQHP TAFEEAIPKS FMISADMAHA VHPNYLDKHE
       370        380        390        400        410        420
ENHRPLFHKG PVIKVNSKQR YASNAVSEAL IREVANKVKV PLQDLMVRND TPCGTTIGPI
       430        440        450        460        470
LASRLGLRVL DLGSPQLAMH SIREMACTTG VLQTLTLFKG FFELFPSLSH NLLVD

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

3 N-termini - 7 C-termini - 0 Cleavages - 2 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9ULA0-1-Acetylation	MQVAMN...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9ULA0-1-Acetylation	MQVAMN...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9ULA0-1-Acetylation	MQVAMN...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9ULA0-5-unknown	MNGKAR...	5		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000400944
Q9ULA0-5-unknown	MNGKAR...	5		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000430630
Q9ULA0-66-unknown	MTRNSS...	66		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000363083
Q9ULA0-66-unknown	MTRNSS...	66		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000412003
Q9ULA0-66-unknown	MTRNSS...	66		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000414739

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SLIGAH	93	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000430630
...NFGPNT	182	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000414739
...ELEKGT	202	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000412003
...CLADTQ	245	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000317252
...LQALID	277	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000400944
...ADMAHA	349	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000410684
...NLLVD	475	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
ANGT_HUMAN	34	AGDR.\|.RVYI	inferred from experiment	unknown	MEROPS	Neidle A	Kelly JA et al.:An aminopeptidase from mouse br... (M18.002)	6854330,
COLI_HUMAN	142	SMEH.\|.HFRW	inferred from experiment	unknown	MEROPS	Neidle A	Kelly JA et al.:An aminopeptidase from mouse br... (M18.002)	6854330,