Q9NY33: Dipeptidyl peptidase 3
Protein names | - Dipeptidyl peptidase 3 - 3.4.14.4 {ECO:0000269|PubMed:11209758, ECO:0000269|PubMed:1515063, ECO:0000269|PubMed:3233187, ECO:0000269|PubMed:9425109} - Dipeptidyl aminopeptidase III - Dipeptidyl arylamidase III - Dipeptidyl peptidase III - DPP III - Enkephalinase B |
---|---|
Gene names | DPP3 |
Organism | Homo sapiens |
Protease Family | M49.001 |
Protease ID | M49.001 |
Chromosome location | |
UniProt ID | Q9NY33 |
6
N-termini
3
C-termini
2
Cleavages
6
Substrates
Sequence
10 20 30 40 50 60
MADTQYILPN DIGVSSLDCR EAFRLLSPTE RLYAYHLSRA AWYGGLAVLL QTSPEAPYIY
70 80 90 100 110 120
ALLSRLFRAQ DPDQLRQHAL AEGLTEEEYQ AFLVYAAGVY SNMGNYKSFG DTKFVPNLPK
130 140 150 160 170 180
EKLERVILGS EAAQQHPEEV RGLWQTCGEL MFSLEPRLRH LGLGKEGITT YFSGNCTMED
190 200 210 220 230 240
AKLAQDFLDS QNLSAYNTRL FKEVDGEGKP YYEVRLASVL GSEPSLDSEV TSKLKSYEFR
250 260 270 280 290 300
GSPFQVTRGD YAPILQKVVE QLEKAKAYAA NSHQGQMLAQ YIESFTQGSI EAHKRGSRFW
310 320 330 340 350 360
IQDKGPIVES YIGFIESYRD PFGSRGEFEG FVAVVNKAMS AKFERLVASA EQLLKELPWP
370 380 390 400 410 420
PTFEKDKFLT PDFTSLDVLT FAGSGIPAGI NIPNYDDLRQ TEGFKNVSLG NVLAVAYATQ
430 440 450 460 470 480
REKLTFLEED DKDLYILWKG PSFDVQVGLH ELLGHGSGKL FVQDEKGAFN FDQETVINPE
490 500 510 520 530 540
TGEQIQSWYR SGETWDSKFS TIASSYEECR AESVGLYLCL HPQVLEIFGF EGADAEDVIY
550 560 570 580 590 600
VNWLNMVRAG LLALEFYTPE AFNWRQAHMQ ARFVILRVLL EAGEGLVTIT PTTGSDGRPD
610 620 630 640 650 660
ARVRLDRSKI RSVGKPALER FLRRLQVLKS TGDVAGGRAL YEGYATVTDA PPECFLTLRD
670 680 690 700 710 720
TVLLRKESRK LIVQPNTRLE GSDVQLLEYE ASAAGLIRSF SERFPEDGPE LEEILTQLAT
730
ADARFWKGPS EAPSGQA
Isoforms
- Isoform 2 of Dipeptidyl peptidase 3 - Isoform 4 of Dipeptidyl peptidase 3Sequence View
10 20 30 40 50 60
MADTQYILPN DIGVSSLDCR EAFRLLSPTE RLYAYHLSRA AWYGGLAVLL QTSPEAPYIY
70 80 90 100 110 120
ALLSRLFRAQ DPDQLRQHAL AEGLTEEEYQ AFLVYAAGVY SNMGNYKSFG DTKFVPNLPK
130 140 150 160 170 180
EKLERVILGS EAAQQHPEEV RGLWQTCGEL MFSLEPRLRH LGLGKEGITT YFSGNCTMED
190 200 210 220 230 240
AKLAQDFLDS QNLSAYNTRL FKEVDGEGKP YYEVRLASVL GSEPSLDSEV TSKLKSYEFR
250 260 270 280 290 300
GSPFQVTRGD YAPILQKVVE QLEKAKAYAA NSHQGQMLAQ YIESFTQGSI EAHKRGSRFW
310 320 330 340 350 360
IQDKGPIVES YIGFIESYRD PFGSRGEFEG FVAVVNKAMS AKFERLVASA EQLLKELPWP
370 380 390 400 410 420
PTFEKDKFLT PDFTSLDVLT FAGSGIPAGI NIPNYDDLRQ TEGFKNVSLG NVLAVAYATQ
430 440 450 460 470 480
REKLTFLEED DKDLYILWKG PSFDVQVGLH ELLGHGSGKL FVQDEKGAFN FDQETVINPE
490 500 510 520 530 540
TGEQIQSWYR SGETWDSKFS TIASSYEECR AESVGLYLCL HPQVLEIFGF EGADAEDVIY
550 560 570 580 590 600
VNWLNMVRAG LLALEFYTPE AFNWRQAHMQ ARFVILRVLL EAGEGLVTIT PTTGSDGRPD
610 620 630 640 650 660
ARVRLDRSKI RSVGKPALER FLRRLQVLKS TGDVAGGRAL YEGYATVTDA PPECFLTLRD
670 680 690 700 710 720
TVLLRKESRK LIVQPNTRLE GSDVQLLEYE ASAAGLIRSF SERFPEDGPE LEEILTQLAT
730
ADARFWKGPS EAPSGQA
10 20 30 40 50 60
MADTQYILPN DIGVSSLDCR EAFRLLSPTE RLYAYHLSRA AWYGGLAVLL QTSPEAPYIY
70 80 90 100 110 120
ALLSRLFRAQ DPDQLRQHAL AEGLTEEEYQ AFLVYAAGVY SNMGNYKSFG DTKFVPNLPK
130 140 150 160 170 180
EKLERVILGS EAAQQHPEEV RGLWQTCGEL MFSLEPRLRH LGLGKEGITT YFSGNCTMED
190 200 210 220 230 240
AKLAQDFLDS QNLSAYNTRL FKEVDGEGKP YYEVRLASVL GSEPSLDSEV TSKLKSYEFR
250 260 270 280 290 300
GSPFQVTRGD YAPILQKVVE QLEKAKAYAA NSHQGQMLAQ YIESFTQGSI EAHKRGSRFW
310 320 330 340 350 360
IQDKGPIVES YIGFIESYRD PFGSRGEFEG FVAVVNKAMS AKFERLVASA EQLLKELPWP
370 380 390 400 410 420
PTFEKDKFLT PDFTSLDVLT FAGSGIPAGI NIPNYDDLRQ TEGFKNVSLG NVLAVAYATQ
430 440 450 460 470 480
REKLTFLEED DKDLYILWKG PSFDVQVGLH ELLGHGSGKL FVQDEKGAFN FDQETVINPE
490 500 510 520 530 540
TGEQIQSWYR SGETWDSKFS TIASSYEECR AESVGLYLCL HPQVLEIFGF EGADAEDVIY
550 560 570 580 590 600
VNWLNMVRAG LLALEFYTPE AFNWRQAHMQ ARFVILRVLL EAGEGLVTIT PTTGSDGRPD
610 620 630 640 650 660
ARVRLDRSKI RSVGKPALER FLRRLQVLKS TGDVAGGRAL YEGYATVTDA PPECFLTLRD
670 680 690 700 710 720
TVLLRKESRK LIVQPNTRLE GSDVQLLEYE ASAAGLIRSF SERFPEDGPE LEEILTQLAT
730
ADARFWKGPS EAPSGQA
Protein Neighborhood
Domains & Features
6 N-termini - 3 C-termini - 2 Cleavages - 6 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
Q9NY33-1-unknown | MADTQY... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt73207 | |||
Q9NY33-1-unknown | MADTQY... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt73208 | |||
Q9NY33-2-unknown | MADTQY... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q9NY33-2-Acetylation | ADTQYI... | 2 | acetylation- | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | ||
Q9NY33-2-Acetylation | ADTQYI... | 2 | acetylation- | COFRADIC | Gevaert K. | Van Damme P et al.: Complementary positional proteomics for screening substrates... | 20526345 | ||
Q9NY33-2-Acetylation | ADTQYI... | 2 | acetylation- | other | CNRS/ISV | Large_scale_NTA_Human | |||
Q9NY33-2-Acetylation | ADTQYI... | 2 | acetylation- | COFRADIC | Gevaert K. | Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates... | 20526345 | ||
Q9NY33-2-Acetylation | ADTQYI... | 2 | acetylation- | N-TAILS | Overall Laboratory | Lange_Huesgen_et_al-RBC | |||
Q9NY33-2-Acetylation | ADTQYI... | 2 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt110294 | ||
Q9NY33-2-Acetylation | ADTQYI... | 2 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt110295 | ||
Q9NY33-126-acetylation | VILGSE... | 126 | acetylation- | N-TAILS | Overall Laboratory | Lange_Huesgen_et_al-RBC | |||
Q9NY33-126-acetylation | VILGSE... | 126 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt183246 | ||
Q9NY33-126-acetylation | VILGSE... | 126 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt183247 | ||
Q9NY33-130-unknown | SEAAQQ... | 130 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6822 | |||
Q9NY33-130-unknown | SEAAQQ... | 130 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC8115 | |||
Q9NY33-130-unknown | SEAAQQ... | 130 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt183249 | |||
Q9NY33-130-unknown | SEAAQQ... | 130 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt143910 | |||
Q9NY33-130- | SEAAQQ... | 130 | N-TAILS | Overall Laboratory | Lange_Huesgen_et_al-RBC |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...RVILGS | 129 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6822 | |||
...RVILGS | 129 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC8115 | |||
...RVILGS | 129 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt127154 | |||
...PSGQA | 737 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...PSGQA | 737 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt68825 | |||
...PSGQA | 737 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt68826 | |||
...PSGQA | 737 | COFRADIC | Gevaert K. | Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates... | 20526345, | |||
...PSGQA | 737 | COFRADIC | Gevaert K. | Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates... | 20526345, |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
CATL1_HUMAN | 129 | ILGS.|.SEAA | inferred from experiment | unknown | MEROPS | Schilling O | Biniossek ML et al.:Proteomic identification of pro... (C01.060) | 21967108, |
CATS_HUMAN | 129 | ILGS.|.SEAA | inferred from experiment | unknown | MEROPS | Schilling O | Biniossek ML et al.:Proteomic identification of pro... (C01.060) | 21967108, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
ANGT_HUMAN | 35 | GDRV.|.VYIH | inferred from experiment | unknown | MEROPS | Merops DPP3_HUMAN -> ANGT_HUMAN @35 | ||
ANGT_HUMAN | 36 | DRVY.|.YIHP | inferred from experiment | unknown | MEROPS | Merops DPP3_HUMAN -> ANGT_HUMAN @36 | ||
ANGT_HUMAN | 37 | RVYI.|.IHPF | inferred from experiment | unknown | MEROPS | Merops DPP3_HUMAN -> ANGT_HUMAN @37 | ||
ANGT_HUMAN | 38 | VYIH.|.HPFH | inferred from experiment | unknown | MEROPS | Merops DPP3_HUMAN -> ANGT_HUMAN @38 | ||
COLI_HUMAN | 144 | EHFR.|.RWGK | inferred from experiment | unknown | MEROPS | Merops DPP3_HUMAN -> COLI_HUMAN @144 | ||
PDYN_HUMAN | 176 | RYGG.|.GFLR | inferred from experiment | unknown | MEROPS | Merops DPP3_HUMAN -> PDYN_HUMAN @176 |