TopFIND 4.0

Q6UW60: Proprotein convertase subtilisin/kexin type 4

General Information

Protein names
- Proprotein convertase subtilisin/kexin type 4
- 3.4.21.-
- Proprotein convertase 4
- PC4
Gene names PCSK4
Organism Homo sapiens
Protease Family S08.074
Protease ID S08.074
Chromosome location
UniProt ID Q6UW60

3

N-termini

1

C-termini

0

Cleavages

140

Substrates

Sequence

        10         20         30         40         50         60 
MRPAPIALWL RLVLALALVR PRAVGWAPVR APIYVSSWAV QVSQGNREVE RLARKFGFVN 
        70         80         90        100        110        120 
LGPIFPDGQY FHLRHRGVVQ QSLTPHWGHR LHLKKNPKVQ WFQQQTLQRR VKRSVVVPTD 
       130        140        150        160        170        180 
PWFSKQWYMN SEAQPDLSIL QAWSQGLSGQ GIVVSVLDDG IEKDHPDLWA NYDPLASYDF 
       190        200        210        220        230        240 
NDYDPDPQPR YTPSKENRHG TRCAGEVAAM ANNGFCGVGV AFNARIGGVR MLDGTITDVI 
       250        260        270        280        290        300 
EAQSLSLQPQ HIHIYSASWG PEDDGRTVDG PGILTREAFR RGVTKGRGGL GTLFIWASGN 
       310        320        330        340        350        360 
GGLHYDNCNC DGYTNSIHTL SVGSTTQQGR VPWYSEACAS TLTTTYSSGV ATDPQIVTTD 
       370        380        390        400        410        420 
LHHGCTDQHT GTSASAPLAA GMIALALEAN PFLTWRDMQH LVVRASKPAH LQAEDWRTNG 
       430        440        450        460        470        480 
VGRQVSHHYG YGLLDAGLLV DTARTWLPTQ PQRKCAVRVQ SRPTPILPLI YIRENVSACA 
       490        500        510        520        530        540 
GLHNSIRSLE HVQAQLTLSY SRRGDLEISL TSPMGTRSTL VAIRPLDVST EGYNNWVFMS 
       550        560        570        580        590        600 
THFWDENPQG VWTLGLENKG YYFNTGTLYR YTLLLYGTAE DMTARPTGPQ VTSSACVQRD 
       610        620        630        640        650        660 
TEGLCQACDG PAYILGQLCL AYCPPRFFNH TRLVTAGPGH TAAPALRVCS SCHASCYTCR 
       670        680        690        700        710        720 
GGSPRDCTSC PPSSTLDQQQ GSCMGPTTPD SRPRLRAAAC PHHRCPASAM VLSLLAVTLG 
       730        740        750    
GPVLCGMSMD LPLYAWLSRA RATPTKPQVW LPAGT

Isoforms

- Isoform 2 of Proprotein convertase subtilisin/kexin type 4

Sequence View

        10         20         30         40         50         60 
MRPAPIALWL RLVLALALVR PRAVGWAPVR APIYVSSWAV QVSQGNREVE RLARKFGFVN 
        70         80         90        100        110        120 
LGPIFPDGQY FHLRHRGVVQ QSLTPHWGHR LHLKKNPKVQ WFQQQTLQRR VKRSVVVPTD 
       130        140        150        160        170        180 
PWFSKQWYMN SEAQPDLSIL QAWSQGLSGQ GIVVSVLDDG IEKDHPDLWA NYDPLASYDF 
       190        200        210        220        230        240 
NDYDPDPQPR YTPSKENRHG TRCAGEVAAM ANNGFCGVGV AFNARIGGVR MLDGTITDVI 
       250        260        270        280        290        300 
EAQSLSLQPQ HIHIYSASWG PEDDGRTVDG PGILTREAFR RGVTKGRGGL GTLFIWASGN 
       310        320        330        340        350        360 
GGLHYDNCNC DGYTNSIHTL SVGSTTQQGR VPWYSEACAS TLTTTYSSGV ATDPQIVTTD 
       370        380        390        400        410        420 
LHHGCTDQHT GTSASAPLAA GMIALALEAN PFLTWRDMQH LVVRASKPAH LQAEDWRTNG 
       430        440        450        460        470        480 
VGRQVSHHYG YGLLDAGLLV DTARTWLPTQ PQRKCAVRVQ SRPTPILPLI YIRENVSACA 
       490        500        510        520        530        540 
GLHNSIRSLE HVQAQLTLSY SRRGDLEISL TSPMGTRSTL VAIRPLDVST EGYNNWVFMS 
       550        560        570        580        590        600 
THFWDENPQG VWTLGLENKG YYFNTGTLYR YTLLLYGTAE DMTARPTGPQ VTSSACVQRD 
       610        620        630        640        650        660 
TEGLCQACDG PAYILGQLCL AYCPPRFFNH TRLVTAGPGH TAAPALRVCS SCHASCYTCR 
       670        680        690        700        710        720 
GGSPRDCTSC PPSSTLDQQQ GSCMGPTTPD SRPRLRAAAC PHHRCPASAM VLSLLAVTLG 
       730        740        750    
GPVLCGMSMD LPLYAWLSRA RATPTKPQVW LPAGT



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Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

3 N-termini - 1 C-termini - 0 Cleavages - 140 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q6UW60-26-unknown WAPVRA... 26 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q6UW60-114-unknown SVVVPT... 114 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q6UW60-514-unknown MGTRST... 514 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt84589

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...LPAGT 755 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...LPAGT 755 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt80207

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates