P02768: Serum albumin

General Information

Protein names	- Serum albumin
Gene names	ALB
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P02768

22 N-termini

7 C-termini

12 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Serum albumin - Isoform 3 of Serum albumin

Sequence View

        10         20         30         40         50         60
MKWVTFISLL FLFSSAYSRG VFRRDAHKSE VAHRFKDLGE ENFKALVLIA FAQYLQQCPF
        70         80         90        100        110        120
EDHVKLVNEV TEFAKTCVAD ESAENCDKSL HTLFGDKLCT VATLRETYGE MADCCAKQEP
       130        140        150        160        170        180
ERNECFLQHK DDNPNLPRLV RPEVDVMCTA FHDNEETFLK KYLYEIARRH PYFYAPELLF
       190        200        210        220        230        240
FAKRYKAAFT ECCQAADKAA CLLPKLDELR DEGKASSAKQ RLKCASLQKF GERAFKAWAV
       250        260        270        280        290        300
ARLSQRFPKA EFAEVSKLVT DLTKVHTECC HGDLLECADD RADLAKYICE NQDSISSKLK
       310        320        330        340        350        360
ECCEKPLLEK SHCIAEVEND EMPADLPSLA ADFVESKDVC KNYAEAKDVF LGMFLYEYAR
       370        380        390        400        410        420
RHPDYSVVLL LRLAKTYETT LEKCCAAADP HECYAKVFDE FKPLVEEPQN LIKQNCELFE
       430        440        450        460        470        480
QLGEYKFQNA LLVRYTKKVP QVSTPTLVEV SRNLGKVGSK CCKHPEAKRM PCAEDYLSVV
       490        500        510        520        530        540
LNQLCVLHEK TPVSDRVTKC CTESLVNRRP CFSALEVDET YVPKEFNAET FTFHADICTL
       550        560        570        580        590        600
SEKERQIKKQ TALVELVKHK PKATKEQLKA VMDDFAAFVE KCCKADDKET CFAEEGKKLV

AASQAALGL         10         20         30         40         50         60
MKWVTFISLL FLFSSAYSRG VFRRDAHKSE VAHRFKDLGE ENFKALVLIA FAQYLQQCPF
        70         80         90        100        110        120
EDHVKLVNEV TEFAKTCVAD ESAENCDKSL HTLFGDKLCT VATLRETYGE MADCCAKQEP
       130        140        150        160        170        180
ERNECFLQHK DDNPNLPRLV RPEVDVMCTA FHDNEETFLK KYLYEIARRH PYFYAPELLF
       190        200        210        220        230        240
FAKRYKAAFT ECCQAADKAA CLLPKLDELR DEGKASSAKQ RLKCASLQKF GERAFKAWAV
       250        260        270        280        290        300
ARLSQRFPKA EFAEVSKLVT DLTKVHTECC HGDLLECADD RADLAKYICE NQDSISSKLK
       310        320        330        340        350        360
ECCEKPLLEK SHCIAEVEND EMPADLPSLA ADFVESKDVC KNYAEAKDVF LGMFLYEYAR
       370        380        390        400        410        420
RHPDYSVVLL LRLAKTYETT LEKCCAAADP HECYAKVFDE FKPLVEEPQN LIKQNCELFE
       430        440        450        460        470        480
QLGEYKFQNA LLVRYTKKVP QVSTPTLVEV SRNLGKVGSK CCKHPEAKRM PCAEDYLSVV
       490        500        510        520        530        540
LNQLCVLHEK TPVSDRVTKC CTESLVNRRP CFSALEVDET YVPKEFNAET FTFHADICTL
       550        560        570        580        590        600
SEKERQIKKQ TALVELVKHK PKATKEQLKA VMDDFAAFVE KCCKADDKET CFAEEGKKLV

AASQAALGL

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Physiological Relevance:

Evidence Codes:

Methodology:

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Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

22 N-termini - 7 C-termini - 12 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P02768-1-unknown	MKWVTF...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt66712
P02768-25-unknown	DAHKSE...	25	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P02768-25-unknown	DAHKSE...	25	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26973
P02768-25-unknown	DAHKSE...	25	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC27269
P02768-25-unknown	DAHKSE...	25	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16277
P02768-25-unknown	DAHKSE...	25	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26521
P02768-25-unknown	DAHKSE...	25	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26828
P02768-25-unknown	DAHKSE...	25	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9699
P02768-25-unknown	DAHKSE...	25	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC27120
P02768-25-unknown	DAHKSE...	25		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P02768-25-unknown	DAHKSE...	25	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt113863
P02768-26-unknown	AHKSEV...	26		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P02768-27-unknown	HKSEVA...	27		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P02768-107-unknown	TYGEMA...	107		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P02768-109-unknown	GEMADC...	109	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8409
P02768-109-unknown	GEMADC...	109		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P02768-111-unknown	MADCCA...	111		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P02768-170-unknown	HPYFYA...	170	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC502
P02768-171-unknown	PYFYAP...	171	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC503
P02768-173-unknown	FYAPEL...	173	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18417
P02768-173-unknown	FYAPEL...	173	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC504
P02768-222-unknown	LKCASL...	222		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P02768-247-unknown	FPKAEF...	247		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P02768-247-unknown	FPKAEF...	247	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt180639
P02768-265-	VHTECC...	265		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P02768-265-unknown	VHTECC...	265	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172387
P02768-272-unknown	GDLLEC...	272		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P02768-272-unknown	GDLLEC...	272	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt180641
P02768-386-unknown	AAADPH...	386		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P02768-386-unknown	AAADPH...	386	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt180643
P02768-486-unknown	VLHEKT...	486		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P02768-486-unknown	VLHEKT...	486	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt180645
P02768-497-unknown	VTKCCT...	497		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P02768-497-unknown	VTKCCT...	497	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt180647
P02768-500-unknown	CCTESL...	500		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P02768-500-unknown	CCTESL...	500	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt180649
P02768-549-unknown	KQTALV...	549		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P02768-549-unknown	KQTALV...	549	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt180651
P02768-563-unknown	ATKEQL...	563		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P02768-563-unknown	ATKEQL...	563	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt180653
P02768-570-unknown	AVMDDF...	570		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P02768-570-unknown	AVMDDF...	570	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt180655

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GVFRRD	24	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26973
...GVFRRD	24	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27269
...GVFRRD	24	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16277
...GVFRRD	24	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26521
...GVFRRD	24	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26828
...GVFRRD	24	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9699
...GVFRRD	24	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27120
...GVFRRD	24	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120096
...LRETYG	108	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8409
...EIARRH	169	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC502
...IARRHP	170	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC503
...RRHPYF	172	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18417
...RRHPYF	172	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC504
...ECCQAA	195	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000392541
...AALGL	609	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...AALGL	609	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt62330

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
PCSK5_HUMAN	24	FRRD.\|.DAHK	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK7_HUMAN	24	FRRD.\|.DAHK	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
KLK4_HUMAN	24	FRRD.\|.DAHK	inferred from experiment	unknown	MEROPS	Nelson PS	Matsumura M et al.:Substrates of the prostate-spec... (S01.251)	15389820,
NEC1_HUMAN	24	FRRD.\|.DAHK	inferred from experiment	unknown	MEROPS	Birch NP	Rufaut NW et al.:Purification and characterizati... (S08.072)	8376387,
PCSK4_HUMAN	24	FRRD.\|.DAHK	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
FURIN_HUMAN	24	FRRD.\|.DAHK	inferred from experiment	unknown	MEROPS	Nakayama K	Brennan SO et al.:Furin has the proalbumin substr... (S08.071)	8307172,
PCSK6_HUMAN	24	FRRD.\|.DAHK	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
CMA1_HUMAN	108	ETYG.\|.GEMA	inferred from experiment	unknown	MEROPS	Caughey GH	Raymond WW et al.:Albumin is a substrate of human... (S01.140)	12815038,
BACE2_HUMAN	169	ARRH.\|.HPYF	inferred from experiment	unknown	MEROPS	Lin X	Kim YT et al.:Enzymic properties of recombina... (A01.041)	12423367,
BACE2_HUMAN	170	RRHP.\|.PYFY	inferred from experiment	unknown	MEROPS	Lin X	Kim YT et al.:Enzymic properties of recombina... (A01.041)	12423367,
MEP1B_HUMAN	172	HPYF.\|.FYAP	inferred from experiment	unknown	MEROPS	Bond JS	Bertenshaw GP et al.:Marked differences between meta... (M12.002)	11278902,
BACE2_HUMAN	172	HPYF.\|.FYAP	inferred from experiment	unknown	MEROPS	Lin X	Kim YT et al.:Enzymic properties of recombina... (A01.041)	12423367,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)