P29120: Neuroendocrine convertase 1

General Information

Protein names	- Neuroendocrine convertase 1 - NEC 1 - 3.4.21.93 - Prohormone convertase 1 - Proprotein convertase 1 - PC1
Gene names	PCSK1
Organism	Homo sapiens
Protease Family	S08.072
Protease ID	S08.072
Chromosome location
UniProt ID	P29120

2 N-termini

2 C-termini

1 Cleavages

29 Substrates

Sequence

        10         20         30         40         50         60
MERRAWSLQC TAFVLFCAWC ALNSAKAKRQ FVNEWAAEIP GGPEAASAIA EELGYDLLGQ
        70         80         90        100        110        120
IGSLENHYLF KHKNHPRRSR RSAFHITKRL SDDDRVIWAE QQYEKERSKR SALRDSALNL
       130        140        150        160        170        180
FNDPMWNQQW YLQDTRMTAA LPKLDLHVIP VWQKGITGKG VVITVLDDGL EWNHTDIYAN
       190        200        210        220        230        240
YDPEASYDFN DNDHDPFPRY DPTNENKHGT RCAGEIAMQA NNHKCGVGVA YNSKVGGIRM
       250        260        270        280        290        300
LDGIVTDAIE ASSIGFNPGH VDIYSASWGP NDDGKTVEGP GRLAQKAFEY GVKQGRQGKG
       310        320        330        340        350        360
SIFVWASGNG GRQGDNCDCD GYTDSIYTIS ISSASQQGLS PWYAEKCSST LATSYSSGDY
       370        380        390        400        410        420
TDQRITSADL HNDCTETHTG TSASAPLAAG IFALALEANP NLTWRDMQHL VVWTSEYDPL
       430        440        450        460        470        480
ANNPGWKKNG AGLMVNSRFG FGLLNAKALV DLADPRTWRS VPEKKECVVK DNDFEPRALK
       490        500        510        520        530        540
ANGEVIIEIP TRACEGQENA IKSLEHVQFE ATIEYSRRGD LHVTLTSAAG TSTVLLAERE
       550        560        570        580        590        600
RDTSPNGFKN WDFMSVHTWG ENPIGTWTLR ITDMSGRIQN EGRIVNWKLI LHGTSSQPEH
       610        620        630        640        650        660
MKQPRVYTSY NTVQNDRRGV EKMVDPGEEQ PTQENPKENT LVSKSPSSSS VGGRRDELEE
       670        680        690        700        710        720
GAPSQAMLRL LQSAFSKNSP PKQSPKKSPS AKLNIPYENF YEALEKLNKP SQLKDSEDSL
       730        740        750
YNDYVDVFYN TKPYKHRDDR LLQALVDILN EEN

Isoforms

- Isoform 2 of Neuroendocrine convertase 1

Sequence View

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Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 1 Cleavages - 29 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P29120-28-unknown	KRQFVN...	28	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P29120-111-unknown	SALRDS...	111	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P29120-111-unknown	SALRDS...	111	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16339
P29120-111-unknown	SALRDS...	111	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115887

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ERSKRS	110	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16339
...ERSKRS	110	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123376
...LNEEN	753	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...LNEEN	753	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78158

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
KLK4_HUMAN	110	SKRS.\|.SALR	inferred from experiment	unknown	MEROPS	Nelson PS	Matsumura M et al.:Substrates of the prostate-spec... (S01.251)	15389820,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
ALBU_HUMAN	24	FRRD.\|.DAHK	inferred from experiment	unknown	MEROPS	Birch NP	Rufaut NW et al.:Purification and characterizati... (S08.072)	8376387,
ALBU-Isoform2_HUMAN	24	FRRD.\|.DAHK	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC26521
INS_HUMAN	56	TRRE.\|.EAED	inferred from experiment	unknown	MEROPS	Chretien M	Seidah NG et al.:Pro-protein convertases of subt... (S08.072)	7845206,
GAST_HUMAN	58	HRRQ.\|.QLGP	inferred from experiment	unknown	MEROPS	Dickinson CJ	Sawada M et al.:Diminished prohormone convertas... (M14.005)	10771309,
RENI_HUMAN	66	MKRL.\|.LTLG	inferred from experiment	unknown	MEROPS	Chretien M	Seidah NG et al.:Pro-protein convertases of subt... (S08.072)	7845206,
RENI-Isoform2_HUMAN	66	MKRL.\|.LTLG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC26503
IAPP_HUMAN	73	GKRN.\|.NAVE	inferred from experiment	unknown	MEROPS	Verchere CB	Wang J et al.:The prohormone convertase enzym... (M14.005)	11246872,
GAST_HUMAN	75	SKKQ.\|.QGPW	inferred from experiment	unknown	MEROPS	Dickinson CJ	Sawada M et al.:Diminished prohormone convertas... (M14.005)	10771309,
AGRP_HUMAN	82	EPRS.\|.SSRR	inferred from experiment	unknown	MEROPS	White A	Creemers JW et al.:Agouti-related protein is postt... (S08.072)	16384863,
GLUC_HUMAN	83	TKRN.\|.NRNN	inferred from experiment	unknown	MEROPS		Merops NEC1_HUMAN -> GLUC_HUMAN @83
TRH_HUMAN	83	SKRQ.\|.QHPG	inferred from experiment	unknown	MEROPS		Merops NEC1_HUMAN -> TRH_HUMAN @83
AGRP_HUMAN	85	SSRR.\|.RCVR	inferred from experiment	unknown	MEROPS	White A	Creemers JW et al.:Agouti-related protein is postt... (S08.072)	16384863,
INS_HUMAN	89	QKRG.\|.GIVE	inferred from experiment	unknown	MEROPS	Chretien M	Seidah NG et al.:Pro-protein convertases of subt... (S08.072)	7845206,
GLUC_HUMAN	91	AKRH.\|.HDEF	inferred from experiment	unknown	MEROPS		Merops NEC1_HUMAN -> GLUC_HUMAN @91
GAST_HUMAN	95	GRRS.\|.SAED	inferred from experiment	unknown	MEROPS	Dickinson CJ	Sawada M et al.:Diminished prohormone convertas... (M14.005)	10771309,
GLUC_HUMAN	97	FERH.\|.HAEG	inferred from experiment	unknown	MEROPS		Merops NEC1_HUMAN -> GLUC_HUMAN @97
TRH_HUMAN	113	HKRQ.\|.QHPG	inferred from experiment	unknown	MEROPS		Merops NEC1_HUMAN -> TRH_HUMAN @113
GLUC_HUMAN	130	GRRD.\|.DFPE	inferred from experiment	unknown	MEROPS		Merops NEC1_HUMAN -> GLUC_HUMAN @130
TRH_HUMAN	134	HKRQ.\|.QHPG	inferred from experiment	unknown	MEROPS		Merops NEC1_HUMAN -> TRH_HUMAN @134
PENK_HUMAN	142	MKKD.\|.DAEE	inferred from experiment	unknown	MEROPS	Chretien M	Seidah NG et al.:Pro-protein convertases of subt... (S08.072)	7845206,
GLUC_HUMAN	145	GRRH.\|.HADG	inferred from in-silico analysis	unknown	MEROPS		Merops NEC1_HUMAN -> GLUC_HUMAN @145
TRH_HUMAN	151	PKRQ.\|.QHPG	inferred from experiment	unknown	MEROPS		Merops NEC1_HUMAN -> TRH_HUMAN @151
PENK_HUMAN	185	SKRY.\|.YGGF	inferred from experiment	unknown	MEROPS	Chretien M	Seidah NG et al.:Pro-protein convertases of subt... (S08.072)	7845206,
TRH_HUMAN	185	EKRQ.\|.QHPG	inferred from experiment	unknown	MEROPS		Merops NEC1_HUMAN -> TRH_HUMAN @185
PENK_HUMAN	195	LKRS.\|.SPQL	inferred from experiment	unknown	MEROPS	Chretien M	Seidah NG et al.:Pro-protein convertases of subt... (S08.072)	7845206,
TRH_HUMAN	226	EKRQ.\|.QHPG	inferred from experiment	unknown	MEROPS		Merops NEC1_HUMAN -> TRH_HUMAN @226
PENK_HUMAN	229	QKRY.\|.YGGF	inferred from experiment	unknown	MEROPS	Chretien M	Seidah NG et al.:Pro-protein convertases of subt... (S08.072)	7845206,
PENK_HUMAN	236	LKRF.\|.FAEA	inferred from experiment	unknown	MEROPS	Chretien M	Seidah NG et al.:Pro-protein convertases of subt... (S08.072)	7845206,
PENK_HUMAN	260	EKRY.\|.YGGF	inferred from experiment	unknown	MEROPS	Chretien M	Seidah NG et al.:Pro-protein convertases of subt... (S08.072)	7845206,