P00797: Renin

General Information

Protein names	- Renin - 3.4.23.15 - Angiotensinogenase
Gene names	REN
Organism	Homo sapiens
Protease Family	A01.007
Protease ID	A01.007
Chromosome location
UniProt ID	P00797

2 N-termini

2 C-termini

5 Cleavages

1 Substrates

Sequence

        10         20         30         40         50         60
MDGWRRMPRW GLLLLLWGSC TFGLPTDTTT FKRIFLKRMP SIRESLKERG VDMARLGPEW
        70         80         90        100        110        120
SQPMKRLTLG NTTSSVILTN YMDTQYYGEI GIGTPPQTFK VVFDTGSSNV WVPSSKCSRL
       130        140        150        160        170        180
YTACVYHKLF DASDSSSYKH NGTELTLRYS TGTVSGFLSQ DIITVGGITV TQMFGEVTEM
       190        200        210        220        230        240
PALPFMLAEF DGVVGMGFIE QAIGRVTPIF DNIISQGVLK EDVFSFYYNR DSENSQSLGG
       250        260        270        280        290        300
QIVLGGSDPQ HYEGNFHYIN LIKTGVWQIQ MKGVSVGSST LLCEDGCLAL VDTGASYISG
       310        320        330        340        350        360
STSSIEKLME ALGAKKRLFD YVVKCNEGPT LPDISFHLGG KEYTLTSADY VFQESYSSKK
       370        380        390        400
LCTLAIHAMD IPPPTGPTWA LGATFIRKFY TEFDRRNNRI GFALAR

Isoforms

- Isoform 2 of Renin

Sequence View

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Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 5 Cleavages - 1 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P00797-1-unknown	MDGWRR...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt87280
P00797-67-unknown	LTLGNT...	67	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P00797-67-unknown	LTLGNT...	67	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26956
P00797-67-unknown	LTLGNT...	67	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16249
P00797-67-unknown	LTLGNT...	67	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26503
P00797-67-unknown	LTLGNT...	67	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9626
P00797-67-unknown	LTLGNT...	67	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3326
P00797-67-unknown	LTLGNT...	67	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115772

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...QPMKRL	66	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26956
...QPMKRL	66	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16249
...QPMKRL	66	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26503
...QPMKRL	66	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9626
...QPMKRL	66	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3326
...QPMKRL	66	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123549
...FALAR	406	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...FALAR	406	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt82898

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
PCSK5_HUMAN	66	MKRL.\|.LTLG	inferred from experiment	unknown	MEROPS		Merops PCSK5_HUMAN -> RENI_HUMAN @66
KLK4_HUMAN	66	MKRL.\|.LTLG	inferred from experiment	unknown	MEROPS	Nelson PS	Matsumura M et al.:Substrates of the prostate-spec... (S01.251)	15389820,
NEC1_HUMAN	66	MKRL.\|.LTLG	inferred from experiment	unknown	MEROPS	Chretien M	Seidah NG et al.:Pro-protein convertases of subt... (S08.072)	7845206,
FA12_HUMAN	66	MKRL.\|.LTLG	inferred from experiment	unknown	MEROPS		Merops FA12_HUMAN -> RENI_HUMAN @66
CATB_HUMAN	66	MKRL.\|.LTLG	inferred from experiment	unknown	MEROPS	Reudelhuber TL	Jutras I et al.:Prorenin processing by cathepsi... (C01.060)	9928950,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
ANGT_HUMAN	43	FHLV.\|.VIHN	inferred from experiment	unknown	MEROPS	Fukamizu A	Hatae T et al.:Comparative studies on species-... (A01.007)	8047064,