P00748: Coagulation factor XII

General Information

Protein names	- Coagulation factor XII - 3.4.21.38 - Hageman factor - HAF - Coagulation factor XIIa heavy chain - Beta-factor XIIa part 1 - Coagulation factor XIIa light chain - Beta-factor XIIa part 2
Gene names	F12
Organism	Homo sapiens
Protease Family	S01.211
Protease ID	S01.211
Chromosome location
UniProt ID	P00748

11 N-termini

10 C-termini

15 Cleavages

8 Substrates

Sequence

        10         20         30         40         50         60
MRALLLLGFL LVSLESTLSI PPWEAPKEHK YKAEEHTVVL TVTGEPCHFP FQYHRQLYHK
        70         80         90        100        110        120
CTHKGRPGPQ PWCATTPNFD QDQRWGYCLE PKKVKDHCSK HSPCQKGGTC VNMPSGPHCL
       130        140        150        160        170        180
CPQHLTGNHC QKEKCFEPQL LRFFHKNEIW YRTEQAAVAR CQCKGPDAHC QRLASQACRT
       190        200        210        220        230        240
NPCLHGGRCL EVEGHRLCHC PVGYTGAFCD VDTKASCYDG RGLSYRGLAR TTLSGAPCQP
       250        260        270        280        290        300
WASEATYRNV TAEQARNWGL GGHAFCRNPD NDIRPWCFVL NRDRLSWEYC DLAQCQTPTQ
       310        320        330        340        350        360
AAPPTPVSPR LHVPLMPAQP APPKPQPTTR TPPQSQTPGA LPAKREQPPS LTRNGPLSCG
       370        380        390        400        410        420
QRLRKSLSSM TRVVGGLVAL RGAHPYIAAL YWGHSFCAGS LIAPCWVLTA AHCLQDRPAP
       430        440        450        460        470        480
EDLTVVLGQE RRNHSCEPCQ TLAVRSYRLH EAFSPVSYQH DLALLRLQED ADGSCALLSP
       490        500        510        520        530        540
YVQPVCLPSG AARPSETTLC QVAGWGHQFE GAEEYASFLQ EAQVPFLSLE RCSAPDVHGS
       550        560        570        580        590        600
SILPGMLCAG FLEGGTDACQ GDSGGPLVCE DQAAERRLTL QGIISWGSGC GDRNKPGVYT
       610
DVAYYLAWIR EHTVS

Isoforms

Sequence View

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name	Publications (PMID)
P00748-20-unknown	IPPWEA...	20	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P00748-29-unknown	HKYKAE...	29	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19977
P00748-29-unknown	HKYKAE...	29	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21281
P00748-31-unknown	YKAEEH...	31	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19978
P00748-94-unknown	VKDHCS...	94	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21282
P00748-351-unknown	LTRNGP...	351	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19979
P00748-351-unknown	LTRNGP...	351	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21435
P00748-354-unknown	NGPLSC...	354	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P00748-354-unknown	NGPLSC...	354	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16683
P00748-363-unknown	LRKSLS...	363	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16684
P00748-366-unknown	SLSSMT...	366		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P00748-373-unknown	VVGGLV...	373	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P00748-373-unknown	VVGGLV...	373	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16685
P00748-373-unknown	VVGGLV...	373	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15202
P00748-373-unknown	VVGGLV...	373	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9625
P00748-373-unknown	VVGGLV...	373		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P00748-377-unknown	LVALRG...	377	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19980
P00748-377-unknown	LVALRG...	377	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21283
P00748-377-unknown	LVALRG...	377	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21436
P00748-380-unknown	LRGAHP...	380	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19981

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EAPKEH	28	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19977
...EAPKEH	28	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21281
...PKEHKY	30	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19978
...LEPKKV	93	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21282
...EQPPSL	350	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19979
...EQPPSL	350	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21435
...PSLTRN	353	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16683
...SCGQRL	362	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...SCGQRL	362	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16684
...SSMTRV	372	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...SSMTRV	372	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16685
...SSMTRV	372	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15202
...SSMTRV	372	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9625
...RVVGGL	376	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19980
...RVVGGL	376	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21283
...RVVGGL	376	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21436
...GGLVAL	379	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19981
...EHTVS	615	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP12_HUMAN	28	PKEH.\|.HKYK	inferred from experiment	unknown	MEROPS	Tschesche H	Hiller O et al.:Matrix metalloproteinases colla... (M10.009)	10930399,
MMP13_HUMAN	28	PKEH.\|.HKYK	inferred from experiment	unknown	MEROPS	Tschesche H	Hiller O et al.:Matrix metalloproteinases colla... (M10.009)	10930399,
MMP12_HUMAN	30	EHKY.\|.YKAE	inferred from experiment	unknown	MEROPS	Tschesche H	Hiller O et al.:Matrix metalloproteinases colla... (M10.009)	10930399,
MMP13_HUMAN	93	PKKV.\|.VKDH	inferred from experiment	unknown	MEROPS	Tschesche H	Hiller O et al.:Matrix metalloproteinases colla... (M10.009)	10930399,
MMP12_HUMAN	350	PPSL.\|.LTRN	inferred from experiment	unknown	MEROPS	Tschesche H	Hiller O et al.:Matrix metalloproteinases colla... (M10.009)	10930399,
MMP14_HUMAN	350	PPSL.\|.LTRN	inferred from experiment	unknown	MEROPS	Tschesche H	Hiller O et al.:Matrix metalloproteinases colla... (M10.009)	10930399,
KLKB1_HUMAN	353	LTRN.\|.NGPL	inferred from experiment	unknown	MEROPS	MacGillivray RT	Cool DE et al.:Characterization of human blood... (S01.212)	3877053,
KLKB1_HUMAN	362	GQRL.\|.LRKS	inferred from experiment	unknown	MEROPS	MacGillivray RT	Cool DE et al.:Characterization of human blood... (S01.212)	3877053,
KLKB1_HUMAN	372	MTRV.\|.VVGG	inferred from experiment	unknown	MEROPS	MacGillivray RT	Cool DE et al.:Characterization of human blood... (S01.212)	3877053,
HEPS_HUMAN	372	MTRV.\|.VVGG	inferred from experiment	unknown	MEROPS	Austin RJ	Herter S et al.:Hepatocyte growth factor is a p... (S01.224)	15839837,
FA12_HUMAN	372	MTRV.\|.VVGG	inferred from experiment	unknown	MEROPS		Merops FA12_HUMAN -> FA12_HUMAN @372
MMP12_HUMAN	376	VGGL.\|.LVAL	inferred from experiment	unknown	MEROPS	Tschesche H	Hiller O et al.:Matrix metalloproteinases colla... (M10.009)	10930399,
MMP13_HUMAN	376	VGGL.\|.LVAL	inferred from experiment	unknown	MEROPS	Murray GI	Leeman MF et al.:The structure, regulation, and ... (M10.013)	12139441,
MMP14_HUMAN	376	VGGL.\|.LVAL	inferred from experiment	unknown	MEROPS	Tschesche H	Hiller O et al.:Matrix metalloproteinases colla... (M10.009)	10930399,
MMP12_HUMAN	379	LVAL.\|.LRGA	inferred from experiment	unknown	MEROPS	Tschesche H	Hiller O et al.:Matrix metalloproteinases colla... (M10.009)	10930399,

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
RENI_HUMAN	66	MKRL.\|.LTLG	inferred from experiment	unknown	MEROPS		Merops FA12_HUMAN -> RENI_HUMAN @66
RENI-Isoform2_HUMAN	66	MKRL.\|.LTLG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC9626
FA7-Isoform2_HUMAN	190	QGRI.\|.IVGG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC9631
FA7_HUMAN	212	QGRI.\|.IVGG	inferred from experiment	unknown	MEROPS		Merops FA12_HUMAN -> FA7_HUMAN @212
FA11-Isoform2_HUMAN	333	KPRI.\|.IVGG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC9628
FA12_HUMAN	372	MTRV.\|.VVGG	inferred from experiment	unknown	MEROPS		Merops FA12_HUMAN -> FA12_HUMAN @372
FA11_HUMAN	387	KPRI.\|.IVGG	inferred from experiment	unknown	MEROPS		Merops FA12_HUMAN -> FA11_HUMAN @387
KLKB1_HUMAN	390	STRI.\|.IVGG	inferred from experiment	unknown	MEROPS	Davie EW	Chung DW et al.:Human plasma prekallikrein, a z... (S01.211)	3521732,

TopFIND

P00748: Coagulation factor XII

General Information

11

N-termini

10

C-termini

15

Cleavages

8

Substrates

Sequence

Isoforms

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Protein Neighborhood

Domains & Features

11 N-termini - 10 C-termini - 15 Cleavages - 8 Substrates

N-termini

C-termini

Cleavages

Substrates