TopFIND 4.0

P05981: Serine protease hepsin

General Information

Protein names
- Serine protease hepsin
- 3.4.21.106 {ECO:0000269|PubMed:15839837, ECO:0000269|PubMed:21875933, ECO:0000305|PubMed:26673890}
- Transmembrane protease serine 1
- Serine protease hepsin non-catalytic chain
- Serine protease hepsin catalytic chain
Gene names HPN
Organism Homo sapiens
Protease Family S01.224
Protease ID S01.224
Chromosome location
UniProt ID P05981

2

N-termini

3

C-termini

1

Cleavages

10

Substrates

Sequence

        10         20         30         40         50         60 
MAQKEGGRTV PCCSRPKVAA LTAGTLLLLT AIGAASWAIV AVLLRSDQEP LYPVQVSSAD 
        70         80         90        100        110        120 
ARLMVFDKTE GTWRLLCSSR SNARVAGLSC EEMGFLRALT HSELDVRTAG ANGTSGFFCV 
       130        140        150        160        170        180 
DEGRLPHTQR LLEVISVCDC PRGRFLAAIC QDCGRRKLPV DRIVGGRDTS LGRWPWQVSL 
       190        200        210        220        230        240 
RYDGAHLCGG SLLSGDWVLT AAHCFPERNR VLSRWRVFAG AVAQASPHGL QLGVQAVVYH 
       250        260        270        280        290        300 
GGYLPFRDPN SEENSNDIAL VHLSSPLPLT EYIQPVCLPA AGQALVDGKI CTVTGWGNTQ 
       310        320        330        340        350        360 
YYGQQAGVLQ EARVPIISND VCNGADFYGN QIKPKMFCAG YPEGGIDACQ GDSGGPFVCE 
       370        380        390        400        410    
DSISRTPRWR LCGIVSWGTG CALAQKPGVY TKVSDFREWI FQAIKTHSEA SGMVTQL

Isoforms



Sequence View



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Protein Neighborhood

Domains & Features

2 N-termini - 3 C-termini - 1 Cleavages - 10 Substrates

N-termini

C-termini

Cleavages

Substrates