P08709: Coagulation factor VII

General Information

Protein names	- Coagulation factor VII - 3.4.21.21 - Proconvertin - Serum prothrombin conversion accelerator - SPCA - Eptacog alfa - Factor VII light chain - Factor VII heavy chain
Gene names	F7
Organism	Homo sapiens
Protease Family	S01.215
Protease ID	S01.215
Chromosome location
UniProt ID	P08709

4 N-termini

2 C-termini

7 Cleavages

11 Substrates

Sequence

        10         20         30         40         50         60
MVSQALRLLC LLLGLQGCLA AGGVAKASGG ETRDMPWKPG PHRVFVTQEE AHGVLHRRRR
        70         80         90        100        110        120
ANAFLEELRP GSLERECKEE QCSFEEAREI FKDAERTKLF WISYSDGDQC ASSPCQNGGS
       130        140        150        160        170        180
CKDQLQSYIC FCLPAFEGRN CETHKDDQLI CVNENGGCEQ YCSDHTGTKR SCRCHEGYSL
       190        200        210        220        230        240
LADGVSCTPT VEYPCGKIPI LEKRNASKPQ GRIVGGKVCP KGECPWQVLL LVNGAQLCGG
       250        260        270        280        290        300
TLINTIWVVS AAHCFDKIKN WRNLIAVLGE HDLSEHDGDE QSRRVAQVII PSTYVPGTTN
       310        320        330        340        350        360
HDIALLRLHQ PVVLTDHVVP LCLPERTFSE RTLAFVRFSL VSGWGQLLDR GATALELMVL
       370        380        390        400        410        420
NVPRLMTQDC LQQSRKVGDS PNITEYMFCA GYSDGSKDSC KGDSGGPHAT HYRGTWYLTG
       430        440        450        460
IVSWGQGCAT VGHFGVYTRV SQYIEWLQKL MRSEPRPGVL LRAPFP

Isoforms

- Isoform B of Coagulation factor VII

Sequence View

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Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 7 Cleavages - 11 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P08709-1-unknown	MVSQAL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt74682
P08709-21-unknown	AGGVAK...	21	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P08709-61-unknown	ANAFLE...	61	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P08709-61-unknown	ANAFLE...	61	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115737
P08709-213-unknown	IVGGKV...	213	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P08709-213-unknown	IVGGKV...	213	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31755
P08709-213-unknown	IVGGKV...	213	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15188
P08709-213-unknown	IVGGKV...	213	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15206
P08709-213-unknown	IVGGKV...	213	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9601
P08709-213-unknown	IVGGKV...	213	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9631
P08709-213-unknown	IVGGKV...	213	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9638
P08709-213-unknown	IVGGKV...	213	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9646
P08709-213-unknown	IVGGKV...	213	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116040

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KPQGRI	212	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...KPQGRI	212	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31755
...KPQGRI	212	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15188
...KPQGRI	212	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15206
...KPQGRI	212	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9601
...KPQGRI	212	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9631
...KPQGRI	212	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9638
...KPQGRI	212	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9646
...KPQGRI	212	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt91980
...RAPFP	466	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...RAPFP	466	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt70300

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
THRB_HUMAN	212	QGRI.\|.IVGG	inferred from experiment	unknown	MEROPS		Merops THRB_HUMAN -> FA7_HUMAN @212
HABP2_HUMAN	212	QGRI.\|.IVGG	inferred from experiment	unknown	MEROPS	Stohr HA	Romisch J et al.:A protease isolated from human ... (S01.033)	10636458,
HEPS_HUMAN	212	QGRI.\|.IVGG	inferred from experiment	unknown	MEROPS	Kisiel W	Kazama Y et al.:Hepsin, a putative membrane-ass... (S01.224)	7814421,
FA10_HUMAN	212	QGRI.\|.IVGG	inferred from experiment	unknown	MEROPS		Merops FA10_HUMAN -> FA7_HUMAN @212
FA12_HUMAN	212	QGRI.\|.IVGG	inferred from experiment	unknown	MEROPS		Merops FA12_HUMAN -> FA7_HUMAN @212
FA7_HUMAN	212	QGRI.\|.IVGG	inferred from experiment	unknown	MEROPS		Merops FA7_HUMAN -> FA7_HUMAN @212
FA9_HUMAN	212	QGRI.\|.IVGG	inferred from experiment	unknown	MEROPS		Merops FA9_HUMAN -> FA7_HUMAN @212

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
FA9-Isoform2_HUMAN	153	LTRA.\|.AETV	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC9633
FA9-Isoform2_HUMAN	188	FTRV.\|.VVGG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC9635
FA7-Isoform2_HUMAN	190	QGRI.\|.IVGG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC9638
FA9_HUMAN	191	LTRA.\|.AETV	inferred from experiment	unknown	MEROPS		Merops FA7_HUMAN -> FA9_HUMAN @191
FA7_HUMAN	212	QGRI.\|.IVGG	inferred from experiment	unknown	MEROPS		Merops FA7_HUMAN -> FA7_HUMAN @212
FA9_HUMAN	226	FTRV.\|.VVGG	inferred from experiment	unknown	MEROPS		Merops FA7_HUMAN -> FA9_HUMAN @226
FA10_HUMAN	234	LTRI.\|.IVGG	inferred from experiment	unknown	MEROPS		Merops FA7_HUMAN -> FA10_HUMAN @234
FA5_HUMAN	707	ATRK.\|.KMHD	inferred from experiment	unknown	MEROPS	Esmon NL	Safa O et al.:Factor VIIa/tissue factor gener... (S01.215)	10026263,
FA5_HUMAN	737	GIRS.\|.SFRN	inferred from experiment	unknown	MEROPS	Esmon NL	Safa O et al.:Factor VIIa/tissue factor gener... (S01.215)	10026263,
FA5_HUMAN	1046	SPRT.\|.TFHP	inferred from experiment	unknown	MEROPS	Esmon NL	Safa O et al.:Factor VIIa/tissue factor gener... (S01.215)	10026263,
FA5_HUMAN	1220	IQRN.\|.NLSP	inferred from experiment	unknown	MEROPS	Esmon NL	Safa O et al.:Factor VIIa/tissue factor gener... (S01.215)	10026263,