Q14520: Hyaluronan-binding protein 2
Protein names | - Hyaluronan-binding protein 2 - 3.4.21.- - Factor VII-activating protease - Factor seven-activating protease - FSAP - Hepatocyte growth factor activator-like protein - Plasma hyaluronan-binding protein - Hyaluronan-binding protein 2 50 kDa heavy chain - Hyaluronan-binding protein 2 50 kDa heavy chain alternate form - Hyaluronan-binding protein 2 27 kDa light chain - Hyaluronan-binding protein 2 27 kDa light chain alternate form |
---|---|
Gene names | HABP2 |
Organism | Homo sapiens |
Protease Family | S01.033 |
Protease ID | S01.033 |
Chromosome location | |
UniProt ID | Q14520 |
8
N-termini
6
C-termini
6
Cleavages
20
Substrates
Sequence
10 20 30 40 50 60
MFARMSDLHV LLLMALVGKT ACGFSLMSLL ESLDPDWTPD QYDYSYEDYN QEENTSSTLT
70 80 90 100 110 120
HAENPDWYYT EDQADPCQPN PCEHGGDCLV HGSTFTCSCL APFSGNKCQK VQNTCKDNPC
130 140 150 160 170 180
GRGQCLITQS PPYYRCVCKH PYTGPSCSQV VPVCRPNPCQ NGATCSRHKR RSKFTCACPD
190 200 210 220 230 240
QFKGKFCEIG SDDCYVGDGY SYRGKMNRTV NQHACLYWNS HLLLQENYNM FMEDAETHGI
250 260 270 280 290 300
GEHNFCRNPD ADEKPWCFIK VTNDKVKWEY CDVSACSAQD VAYPEESPTE PSTKLPGFDS
310 320 330 340 350 360
CGKTEIAERK IKRIYGGFKS TAGKHPWQAS LQSSLPLTIS MPQGHFCGGA LIHPCWVLTA
370 380 390 400 410 420
AHCTDIKTRH LKVVLGDQDL KKEEFHEQSF RVEKIFKYSH YNERDEIPHN DIALLKLKPV
430 440 450 460 470 480
DGHCALESKY VKTVCLPDGS FPSGSECHIS GWGVTETGKG SRQLLDAKVK LIANTLCNSR
490 500 510 520 530 540
QLYDHMIDDS MICAGNLQKP GQDTCQGDSG GPLTCEKDGT YYVYGIVSWG LECGKRPGVY
550 560
TQVTKFLNWI KATIKSESGF
Isoforms
- Isoform 2 of Hyaluronan-binding protein 2Sequence View
10 20 30 40 50 60
MFARMSDLHV LLLMALVGKT ACGFSLMSLL ESLDPDWTPD QYDYSYEDYN QEENTSSTLT
70 80 90 100 110 120
HAENPDWYYT EDQADPCQPN PCEHGGDCLV HGSTFTCSCL APFSGNKCQK VQNTCKDNPC
130 140 150 160 170 180
GRGQCLITQS PPYYRCVCKH PYTGPSCSQV VPVCRPNPCQ NGATCSRHKR RSKFTCACPD
190 200 210 220 230 240
QFKGKFCEIG SDDCYVGDGY SYRGKMNRTV NQHACLYWNS HLLLQENYNM FMEDAETHGI
250 260 270 280 290 300
GEHNFCRNPD ADEKPWCFIK VTNDKVKWEY CDVSACSAQD VAYPEESPTE PSTKLPGFDS
310 320 330 340 350 360
CGKTEIAERK IKRIYGGFKS TAGKHPWQAS LQSSLPLTIS MPQGHFCGGA LIHPCWVLTA
370 380 390 400 410 420
AHCTDIKTRH LKVVLGDQDL KKEEFHEQSF RVEKIFKYSH YNERDEIPHN DIALLKLKPV
430 440 450 460 470 480
DGHCALESKY VKTVCLPDGS FPSGSECHIS GWGVTETGKG SRQLLDAKVK LIANTLCNSR
490 500 510 520 530 540
QLYDHMIDDS MICAGNLQKP GQDTCQGDSG GPLTCEKDGT YYVYGIVSWG LECGKRPGVY
550 560
TQVTKFLNWI KATIKSESGF
Protein Neighborhood
Domains & Features
8 N-termini - 6 C-termini - 6 Cleavages - 20 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
Q14520-24-unknown | FSLMSL... | 24 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q14520-27-unknown | MSLLES... | 27 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q14520-27-unknown | MSLLES... | 27 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt76709 | |||
Q14520-171-unknown | RSKFTC... | 171 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15190 | |||
Q14520-171-unknown | RSKFTC... | 171 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt144524 | |||
Q14520-171-unknown | RSKFTC... | 171 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q14520-171-unknown | RSKFTC... | 171 | inferred from similarity | unknown | UniProtKB | inferred from uniprot (by similarity) | |||
Q14520-172-unknown | SKFTCA... | 172 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15192 | |||
Q14520-172-unknown | SKFTCA... | 172 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt144560 | |||
Q14520-172-unknown | SKFTCA... | 172 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q14520-172-unknown | SKFTCA... | 172 | inferred from similarity | unknown | UniProtKB | inferred from uniprot (by similarity) | |||
Q14520-314-unknown | IYGGFK... | 314 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q14520-314-unknown | IYGGFK... | 314 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15194 | |||
Q14520-314-unknown | IYGGFK... | 314 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC32094 | |||
Q14520-314-unknown | IYGGFK... | 314 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt116146 | |||
Q14520-314-unknown | IYGGFK... | 314 | inferred from similarity | unknown | UniProtKB | inferred from uniprot (by similarity) | |||
Q14520-320-unknown | STAGKH... | 320 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q14520-320-unknown | STAGKH... | 320 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15196 | |||
Q14520-320-unknown | STAGKH... | 320 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt116153 | |||
Q14520-471-unknown | LIANTL... | 471 | unknown | Wildes D. et al: Sampling the N-terminal proteome of human blood | 20173099 | ||||
Q14520-471-unknown | LIANTL... | 471 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt180470 | |||
Q14520-481-unknown | QLYDHM... | 481 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15198 | |||
Q14520-481-unknown | QLYDHM... | 481 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt152838 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...SRHKRR | 170 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15190 | |||
...SRHKRR | 170 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt127791 | |||
...RHKRRS | 171 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15192 | |||
...RHKRRS | 171 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt127827 | |||
...RKIKRI | 313 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...RKIKRI | 313 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15194 | |||
...RKIKRI | 313 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC32094 | |||
...RKIKRI | 313 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt92352 | |||
...YGGFKS | 319 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15196 | |||
...YGGFKS | 319 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt133090 | |||
...LCNSRQ | 480 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15198 | |||
...LCNSRQ | 480 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt136263 | |||
...SESGF | 560 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...SESGF | 560 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt72327 |
Cleavages
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
FIBB_HUMAN | 83 | TQKK.|.KVER | inferred from experiment | unknown | MEROPS | Tomita M | Choi-Miura NH et al.:Identification of the substrate... (S01.033) | 11217080, |
HABP2-Isoform2_HUMAN | 144 | HKRR.|.RSKF | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC15190 | ||
HABP2-Isoform2_HUMAN | 145 | KRRS.|.SKFT | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC15192 | ||
HABP2_HUMAN | 170 | HKRR.|.RSKF | inferred from experiment | unknown | MEROPS | Tomita M | Choi-Miura NH et al.:Proteolytic activation and inac... (S01.033) | 11379758, |
HABP2_HUMAN | 171 | KRRS.|.SKFT | inferred from experiment | unknown | MEROPS | Tomita M | Choi-Miura NH et al.:Proteolytic activation and inac... (S01.033) | 11379758, |
FA7-Isoform2_HUMAN | 190 | QGRI.|.IVGG | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC15188 | ||
FA7_HUMAN | 212 | QGRI.|.IVGG | inferred from experiment | unknown | MEROPS | Stohr HA | Romisch J et al.:A protease isolated from human ... (S01.033) | 10636458, |
HABP2-Isoform2_HUMAN | 287 | IKRI.|.IYGG | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC15194 | ||
HABP2-Isoform2_HUMAN | 293 | GFKS.|.STAG | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC15196 | ||
HABP2_HUMAN | 313 | IKRI.|.IYGG | inferred from experiment | unknown | MEROPS | Tomita M | Choi-Miura NH et al.:Proteolytic activation and inac... (S01.033) | 11379758, |
HABP2_HUMAN | 319 | GFKS.|.STAG | inferred from experiment | unknown | MEROPS | Tomita M | Choi-Miura NH et al.:Proteolytic activation and inac... (S01.033) | 11379758, |
KNG1-Isoform3_HUMAN | 345 | MKRP.|.PPGF | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC15180 | ||
KNG1-Isoform3_HUMAN | 353 | PFRS.|.SSRI | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC15183 | ||
KNG1_HUMAN | 381 | MKRP.|.PPGF | inferred from experiment | unknown | MEROPS | Johannes D | Etscheid M et al.:The hyaluronan-binding serine p... (S01.033) | 12452440, |
KNG1-Isoform2_HUMAN | 381 | MKRP.|.PPGF | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC15180 | ||
KNG1_HUMAN | 389 | PFRS.|.SSRI | inferred from experiment | unknown | MEROPS | Johannes D | Etscheid M et al.:The hyaluronan-binding serine p... (S01.033) | 12452440, |
KNG1-Isoform2_HUMAN | 389 | PFRS.|.SSRI | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC15183 | ||
KNG1_HUMAN | 437 | KQRK.|.KHNL | inferred from experiment | unknown | MEROPS | Johannes D | Etscheid M et al.:The hyaluronan-binding serine p... (S01.033) | 12452440, |
HABP2-Isoform2_HUMAN | 454 | NSRQ.|.QLYD | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC15198 | ||
HABP2_HUMAN | 480 | NSRQ.|.QLYD | inferred from experiment | unknown | MEROPS | Tomita M | Choi-Miura NH et al.:Proteolytic activation and inac... (S01.033) | 11379758, |