P02675: Fibrinogen beta chain

General Information

Protein names	- Fibrinogen beta chain - Fibrinopeptide B - Fibrinogen beta chain
Gene names	FGB
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P02675

16 N-termini

16 C-termini

27 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MKRMVSWSFH KLKTMKHLLL LLLCVFLVKS QGVNDNEEGF FSARGHRPLD KKREEAPSLR
        70         80         90        100        110        120
PAPPPISGGG YRARPAKAAA TQKKVERKAP DAGGCLHADP DLGVLCPTGC QLQEALLQQE
       130        140        150        160        170        180
RPIRNSVDEL NNNVEAVSQT SSSSFQYMYL LKDLWQKRQK QVKDNENVVN EYSSELEKHQ
       190        200        210        220        230        240
LYIDETVNSN IPTNLRVLRS ILENLRSKIQ KLESDVSAQM EYCRTPCTVS CNIPVVSGKE
       250        260        270        280        290        300
CEEIIRKGGE TSEMYLIQPD SSVKPYRVYC DMNTENGGWT VIQNRQDGSV DFGRKWDPYK
       310        320        330        340        350        360
QGFGNVATNT DGKNYCGLPG EYWLGNDKIS QLTRMGPTEL LIEMEDWKGD KVKAHYGGFT
       370        380        390        400        410        420
VQNEANKYQI SVNKYRGTAG NALMDGASQL MGENRTMTIH NGMFFSTYDR DNDGWLTSDP
       430        440        450        460        470        480
RKQCSKEDGG GWWYNRCHAA NPNGRYYWGG QYTWDMAKHG TDDGVVWMNW KGSWYSMRKM
       490
SMKIRPFFPQ Q

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

16 N-termini - 16 C-termini - 27 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P02675-45-unknown	GHRPLD...	45	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P02675-45-unknown	GHRPLD...	45	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16425
P02675-45-unknown	GHRPLD...	45	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15924
P02675-45-unknown	GHRPLD...	45	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21466
P02675-45-unknown	GHRPLD...	45	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31741
P02675-52-unknown	KREEAP...	52	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27460
P02675-52-unknown	KREEAP...	52	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31970
P02675-73-unknown	ARPAKA...	73	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27461
P02675-78-unknown	AAATQK...	78	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27462
P02675-81-unknown	TQKKVE...	81	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23721
P02675-81-unknown	TQKKVE...	81	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21467
P02675-82-unknown	QKKVER...	82	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23722
P02675-84-unknown	KVERKA...	84	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16426
P02675-84-unknown	KVERKA...	84	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27463
P02675-84-unknown	KVERKA...	84	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15187
P02675-124-unknown	RNSVDE...	124	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21371
P02675-151-unknown	LKDLWQ...	151	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23723
P02675-151-unknown	LKDLWQ...	151	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23993
P02675-154-unknown	LWQKRQ...	154	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23994
P02675-154-unknown	LWQKRQ...	154	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21468
P02675-157-unknown	KRQKQV...	157	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23724
P02675-164-unknown	DNENVV...	164	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27464
P02675-168-unknown	VVNEYS...	168	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21469
P02675-172-unknown	YSSELE...	172	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23725
P02675-172-unknown	YSSELE...	172	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23995
P02675-172-unknown	YSSELE...	172	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21470
P02675-178-unknown	KHQLYI...	178	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8278
P02675-178-unknown	KHQLYI...	178	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8322
P02675-220-unknown	MEYCRT...	220	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000426757

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...FFSARG	44	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16425
...FFSARG	44	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15924
...FFSARG	44	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21466
...FFSARG	44	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31741
...RPLDKK	51	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27460
...RPLDKK	51	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31970
...GGGYRA	72	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27461
...ARPAKA	77	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27462
...AKAAAT	80	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23721
...AKAAAT	80	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21467
...KAAATQ	81	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23722
...AATQKK	83	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16426
...AATQKK	83	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27463
...AATQKK	83	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15187
...QERPIR	123	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21371
...QYMYLL	150	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23723
...QYMYLL	150	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23993
...YLLKDL	153	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23994
...YLLKDL	153	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21468
...KDLWQK	156	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23724
...QKQVKD	163	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27464
...KDNENV	167	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21469
...NVVNEY	171	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23725
...NVVNEY	171	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23995
...NVVNEY	171	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21470
...SSELEK	177	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8278
...SSELEK	177	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8322
...FFPQQ	491	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
KLK5_HUMAN	44	SARG.\|.GHRP	inferred from experiment	unknown	MEROPS	Diamandis EP	Michael IP et al.:Biochemical and enzymatic chara... (S01.017)	15713679,
KLK14_HUMAN	44	SARG.\|.GHRP	inferred from experiment	unknown	MEROPS	Diamandis EP	Borgono CA et al.:Expression and functional chara... (S01.029)	17110383,
MMP14_HUMAN	44	SARG.\|.GHRP	inferred from experiment	unknown	MEROPS	Kudryk BJ	Bini A et al.:Characterization of stromelysin... (M10.014)	10529239,
THRB_HUMAN	44	SARG.\|.GHRP	inferred from experiment	unknown	MEROPS		Merops THRB_HUMAN -> FIBB_HUMAN @44
PLMN_HUMAN	51	LDKK.\|.KREE	inferred from experiment	unknown	MEROPS	Traynelis SF	Yuan H et al.:The serine protease plasmin cle... (S01.233)	19240037,
TRYB1_HUMAN	51	LDKK.\|.KREE	inferred from experiment	unknown	MEROPS	Johnson DA	Thomas VA et al.:Human mast cell tryptase fibrin... (S01.143)	9485375,
PLMN_HUMAN	72	GYRA.\|.ARPA	inferred from experiment	unknown	MEROPS	Traynelis SF	Yuan H et al.:The serine protease plasmin cle... (S01.233)	19240037,
PLMN_HUMAN	77	PAKA.\|.AAAT	inferred from experiment	unknown	MEROPS	Traynelis SF	Yuan H et al.:The serine protease plasmin cle... (S01.233)	19240037,
MMP3_HUMAN	80	AAAT.\|.TQKK	inferred from experiment	unknown	MEROPS	Kudryk BJ	Bini A et al.:Characterization of stromelysin... (M10.014)	10529239,
MMP14_HUMAN	80	AAAT.\|.TQKK	inferred from experiment	unknown	MEROPS	Kudryk BJ	Bini A et al.:Characterization of stromelysin... (M10.014)	10529239,
MMP3_HUMAN	81	AATQ.\|.QKKV	inferred from experiment	unknown	MEROPS	Kudryk BJ	Bini A et al.:Characterization of stromelysin... (M10.014)	10529239,
KLK5_HUMAN	83	TQKK.\|.KVER	inferred from experiment	unknown	MEROPS	Diamandis EP	Michael IP et al.:Biochemical and enzymatic chara... (S01.017)	15713679,
PLMN_HUMAN	83	TQKK.\|.KVER	inferred from experiment	unknown	MEROPS	Traynelis SF	Yuan H et al.:The serine protease plasmin cle... (S01.233)	19240037,
HABP2_HUMAN	83	TQKK.\|.KVER	inferred from experiment	unknown	MEROPS	Tomita M	Choi-Miura NH et al.:Identification of the substrate... (S01.033)	11217080,
MMP13_HUMAN	123	RPIR.\|.RNSV	inferred from experiment	unknown	MEROPS	Tschesche H	Hiller O et al.:Matrix metalloproteinases colla... (M10.009)	10930399,
MMP3_HUMAN	150	MYLL.\|.LKDL	inferred from experiment	unknown	MEROPS	Kudryk BJ	Bini A et al.:Characterization of stromelysin... (M10.014)	10529239,
MMP7_HUMAN	150	MYLL.\|.LKDL	inferred from experiment	unknown	MEROPS	Kudryk BJ	Bini A et al.:Characterization of stromelysin... (M10.014)	10529239,
MMP7_HUMAN	153	LKDL.\|.LWQK	inferred from experiment	unknown	MEROPS	Kudryk BJ	Bini A et al.:Characterization of stromelysin... (M10.014)	10529239,
MMP14_HUMAN	153	LKDL.\|.LWQK	inferred from experiment	unknown	MEROPS	Kudryk BJ	Bini A et al.:Characterization of stromelysin... (M10.014)	10529239,
MMP3_HUMAN	156	LWQK.\|.KRQK	inferred from experiment	unknown	MEROPS	Kudryk BJ	Bini A et al.:Characterization of stromelysin... (M10.014)	10529239,
PLMN_HUMAN	163	QVKD.\|.DNEN	inferred from experiment	unknown	MEROPS	Kudryk BJ	Bini A et al.:Characterization of stromelysin... (M10.014)	10529239,
MMP14_HUMAN	167	NENV.\|.VVNE	inferred from experiment	unknown	MEROPS	Kudryk BJ	Bini A et al.:Characterization of stromelysin... (M10.014)	10529239,
MMP3_HUMAN	171	VNEY.\|.YSSE	inferred from experiment	unknown	MEROPS	Kudryk BJ	Bini A et al.:Characterization of stromelysin... (M10.014)	10529239,
MMP7_HUMAN	171	VNEY.\|.YSSE	inferred from experiment	unknown	MEROPS	Kudryk BJ	Bini A et al.:Characterization of stromelysin... (M10.014)	10529239,
MMP14_HUMAN	171	VNEY.\|.YSSE	inferred from experiment	unknown	MEROPS	Kudryk BJ	Bini A et al.:Characterization of stromelysin... (M10.014)	10529239,
CBPB2_HUMAN	177	ELEK.\|.KHQL	inferred from experiment	unknown	MEROPS	Leung LL	Myles T et al.:Thrombin activatable fibrinolys... (M14.009)	14525995,
CBPN_HUMAN	177	ELEK.\|.KHQL	inferred from experiment	unknown	MEROPS	Leung LL	Myles T et al.:Thrombin activatable fibrinolys... (M14.009)	14525995,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)