P00740: Coagulation factor IX {ECO:0000303|PubMed:3857619}

General Information

Protein names	- Coagulation factor IX {ECO:0000303\|PubMed:3857619} - 3.4.21.22 {ECO:0000269\|PubMed:12444082, ECO:0000269\|PubMed:20121197, ECO:0000269\|PubMed:20121198, ECO:0000269\|PubMed:2592373} - Christmas factor - Plasma thromboplastin component - PTC - Coagulation factor IXa light chain - Coagulation factor IXa heavy chain
Gene names	F9
Organism	Homo sapiens
Protease Family	S01.214
Protease ID	S01.214
Chromosome location
UniProt ID	P00740

14 N-termini

12 C-termini

15 Cleavages

4 Substrates

Sequence

        10         20         30         40         50         60
MQRVNMIMAE SPGLITICLL GYLLSAECTV FLDHENANKI LNRPKRYNSG KLEEFVQGNL
        70         80         90        100        110        120
ERECMEEKCS FEEAREVFEN TERTTEFWKQ YVDGDQCESN PCLNGGSCKD DINSYECWCP
       130        140        150        160        170        180
FGFEGKNCEL DVTCNIKNGR CEQFCKNSAD NKVVCSCTEG YRLAENQKSC EPAVPFPCGR
       190        200        210        220        230        240
VSVSQTSKLT RAETVFPDVD YVNSTEAETI LDNITQSTQS FNDFTRVVGG EDAKPGQFPW
       250        260        270        280        290        300
QVVLNGKVDA FCGGSIVNEK WIVTAAHCVE TGVKITVVAG EHNIEETEHT EQKRNVIRII
       310        320        330        340        350        360
PHHNYNAAIN KYNHDIALLE LDEPLVLNSY VTPICIADKE YTNIFLKFGS GYVSGWGRVF
       370        380        390        400        410        420
HKGRSALVLQ YLRVPLVDRA TCLRSTKFTI YNNMFCAGFH EGGRDSCQGD SGGPHVTEVE
       430        440        450        460
GTSFLTGIIS WGEECAMKGK YGIYTKVSRY VNWIKEKTKL T

Isoforms

- Isoform 2 of Coagulation factor IX

Sequence View

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Protein Neighborhood

Domains & Features

14 N-termini - 12 C-termini - 15 Cleavages - 4 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name	Publications (PMID)
P00740-1-unknown	MQRVNM...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt74707
P00740-29-unknown	TVFLDH...	29	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P00740-29-unknown	TVFLDH...	29	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt114563
P00740-47-unknown	YNSGKL...	47	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P00740-47-unknown	YNSGKL...	47	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9677
P00740-47-unknown	YNSGKL...	47	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115573
P00740-148-unknown	SADNKV...	148		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P00740-148-unknown	SADNKV...	148	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt180237
P00740-187-unknown	SKLTRA...	187	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8619
P00740-187-unknown	SKLTRA...	187	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144694
P00740-191-unknown	RAETVF...	191	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8621
P00740-191-unknown	RAETVF...	191	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144863
P00740-192-unknown	AETVFP...	192	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9614
P00740-192-unknown	AETVFP...	192	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9633
P00740-192-unknown	AETVFP...	192	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144905
P00740-211-unknown	LDNITQ...	211	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8623
P00740-211-unknown	LDNITQ...	211	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt145639
P00740-219-unknown	QSFNDF...	219	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8625
P00740-219-unknown	QSFNDF...	219	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt145939
P00740-227-unknown	VVGGED...	227	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P00740-227-unknown	VVGGED...	227	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15200
P00740-227-unknown	VVGGED...	227	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16246
P00740-227-unknown	VVGGED...	227	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9616
P00740-227-unknown	VVGGED...	227	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9635
P00740-227-unknown	VVGGED...	227	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116079
P00740-228-unknown	VGGEDA...	228	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8627
P00740-228-unknown	VGGEDA...	228	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt146254
P00740-365-unknown	SALVLQ...	365	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31728
P00740-365-unknown	SALVLQ...	365		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P00740-365-unknown	SALVLQ...	365	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150471
P00740-374-unknown	VPLVDR...	374	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31730
P00740-374-unknown	VPLVDR...	374	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150647
P00740-385-unknown	STKFTI...	385	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31732
P00740-385-unknown	STKFTI...	385	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150896

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...NRPKRY	46	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9677
...NRPKRY	46	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121995
...SVSQTS	186	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8619
...SVSQTS	186	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127962
...TSKLTR	190	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8621
...TSKLTR	190	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128139
...SKLTRA	191	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...SKLTRA	191	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9614
...SKLTRA	191	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9633
...SKLTRA	191	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt91895
...EAETIL	210	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8623
...EAETIL	210	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128938
...ITQSTQ	218	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8625
...ITQSTQ	218	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129236
...NDFTRV	226	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15200
...NDFTRV	226	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16246
...NDFTRV	226	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9616
...NDFTRV	226	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9635
...NDFTRV	226	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129517
...DFTRVV	227	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8627
...DFTRVV	227	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129558
...FHKGRS	364	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31728
...FHKGRS	364	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133866
...LQYLRV	373	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31730
...LQYLRV	373	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134045
...ATCLRS	384	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31732
...ATCLRS	384	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134298
...KTKLT	461	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...KTKLT	461	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt70325

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
FURIN_HUMAN	46	PKRY.\|.YNSG	inferred from experiment	unknown	MEROPS	Kaufman RJ	Wasley LC et al.:PACE/furin can process the vita... (S08.071)	8473289,
ELNE_HUMAN	186	SQTS.\|.SKLT	inferred from experiment	unknown	MEROPS	Giles AR	Samis JA et al.:Neutrophil elastase cleavage of... (S01.131)	9694717,
ELNE_HUMAN	190	KLTR.\|.RAET	inferred from experiment	unknown	MEROPS	Giles AR	Samis JA et al.:Neutrophil elastase cleavage of... (S01.131)	9694717,
FA11_HUMAN	191	LTRA.\|.AETV	inferred from experiment	unknown	MEROPS		Merops FA11_HUMAN -> FA9_HUMAN @191
FA7_HUMAN	191	LTRA.\|.AETV	inferred from experiment	unknown	MEROPS		Merops FA7_HUMAN -> FA9_HUMAN @191
ELNE_HUMAN	210	ETIL.\|.LDNI	inferred from experiment	unknown	MEROPS	Giles AR	Samis JA et al.:Neutrophil elastase cleavage of... (S01.131)	9694717,
ELNE_HUMAN	218	QSTQ.\|.QSFN	inferred from experiment	unknown	MEROPS	Giles AR	Samis JA et al.:Neutrophil elastase cleavage of... (S01.131)	9694717,
HEPS_HUMAN	226	FTRV.\|.VVGG	inferred from experiment	unknown	MEROPS	Austin RJ	Herter S et al.:Hepatocyte growth factor is a p... (S01.224)	15839837,
KLK4_HUMAN	226	FTRV.\|.VVGG	inferred from experiment	unknown	MEROPS	Nelson PS	Matsumura M et al.:Substrates of the prostate-spec... (S01.251)	15389820,
FA11_HUMAN	226	FTRV.\|.VVGG	inferred from experiment	unknown	MEROPS		Merops FA11_HUMAN -> FA9_HUMAN @226
FA7_HUMAN	226	FTRV.\|.VVGG	inferred from experiment	unknown	MEROPS		Merops FA7_HUMAN -> FA9_HUMAN @226
ELNE_HUMAN	227	TRVV.\|.VGGE	inferred from experiment	unknown	MEROPS	Giles AR	Samis JA et al.:Neutrophil elastase cleavage of... (S01.131)	9694717,
THRB_HUMAN	364	KGRS.\|.SALV	inferred from experiment	unknown	MEROPS	McMullen BA	Kisiel W et al.:Proteolytic inactivation of blo... (S01.217)	4063523,
THRB_HUMAN	373	YLRV.\|.VPLV	inferred from experiment	unknown	MEROPS	McMullen BA	Kisiel W et al.:Proteolytic inactivation of blo... (S01.217)	4063523,
THRB_HUMAN	384	CLRS.\|.STKF	inferred from experiment	unknown	MEROPS	McMullen BA	Kisiel W et al.:Proteolytic inactivation of blo... (S01.217)	4063523,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
FA7-Isoform2_HUMAN	190	QGRI.\|.IVGG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC9646
FA7_HUMAN	212	QGRI.\|.IVGG	inferred from experiment	unknown	MEROPS		Merops FA9_HUMAN -> FA7_HUMAN @212
FA10_HUMAN	234	LTRI.\|.IVGG	inferred from experiment	unknown	MEROPS		Merops FA9_HUMAN -> FA10_HUMAN @234
FA8_HUMAN	355	QLRM.\|.MKNN	inferred from experiment	unknown	MEROPS	Fay PJ	Nogami K et al.:Mechanisms of factor Xa-catalyz... (S01.216)	12606556,