P00742: Coagulation factor X

General Information

Protein names	- Coagulation factor X - 3.4.21.6 - Stuart factor - Stuart-Prower factor - Factor X light chain - Factor X heavy chain - Activated factor Xa heavy chain
Gene names	F10
Organism	Homo sapiens
Protease Family	S01.216
Protease ID	S01.216
Chromosome location
UniProt ID	P00742

12 N-termini

10 C-termini

11 Cleavages

24 Substrates

Sequence

        10         20         30         40         50         60
MGRPLHLVLL SASLAGLLLL GESLFIRREQ ANNILARVTR ANSFLEEMKK GHLERECMEE
        70         80         90        100        110        120
TCSYEEAREV FEDSDKTNEF WNKYKDGDQC ETSPCQNQGK CKDGLGEYTC TCLEGFEGKN
       130        140        150        160        170        180
CELFTRKLCS LDNGDCDQFC HEEQNSVVCS CARGYTLADN GKACIPTGPY PCGKQTLERR
       190        200        210        220        230        240
KRSVAQATSS SGEAPDSITW KPYDAADLDP TENPFDLLDF NQTQPERGDN NLTRIVGGQE
       250        260        270        280        290        300
CKDGECPWQA LLINEENEGF CGGTILSEFY ILTAAHCLYQ AKRFKVRVGD RNTEQEEGGE
       310        320        330        340        350        360
AVHEVEVVIK HNRFTKETYD FDIAVLRLKT PITFRMNVAP ACLPERDWAE STLMTQKTGI
       370        380        390        400        410        420
VSGFGRTHEK GRQSTRLKML EVPYVDRNSC KLSSSFIITQ NMFCAGYDTK QEDACQGDSG
       430        440        450        460        470        480
GPHVTRFKDT YFVTGIVSWG EGCARKGKYG IYTKVTAFLK WIDRSMKTRG LPKAKSHAPE

VITSSPLK

Isoforms

Sequence View

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P00742-32-unknown	NNILAR...	32	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P00742-41-unknown	ANSFLE...	41	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P00742-180-unknown	RKRSVA...	180	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8268
P00742-181-unknown	KRSVAQ...	181	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8269
P00742-182-unknown	RSVAQA...	182	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8270
P00742-183-unknown	SVAQAT...	183	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P00742-216-unknown	DLLDFN...	216	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4741
P00742-218-unknown	LDFNQT...	218	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4742
P00742-235-unknown	IVGGQE...	235	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P00742-235-unknown	IVGGQE...	235	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16248
P00742-235-unknown	IVGGQE...	235	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9637
P00742-235-unknown	IVGGQE...	235	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9645
P00742-336-unknown	MNVAPA...	336	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27439
P00742-371-unknown	GRQSTR...	371	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27440
P00742-373-unknown	QSTRLK...	373	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9598

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...QTLERR	179	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...QTLERR	179	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8268
...TLERRK	180	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8269
...LERRKR	181	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8270
...TENPFD	215	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4741
...NPFDLL	217	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4742
...NNLTRI	234	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16248
...NNLTRI	234	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9637
...NNLTRI	234	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9645
...PITFRM	335	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27439
...RTHEKG	370	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27440
...HEKGRQ	372	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9598
...SSPLK	488	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CBPB2_HUMAN	179	LERR.\|.RKRS	inferred from experiment	unknown	MEROPS		Merops CBPB2_HUMAN -> FA10_HUMAN @179
CBPB2_HUMAN	180	ERRK.\|.KRSV	inferred from experiment	unknown	MEROPS		Merops CBPB2_HUMAN -> FA10_HUMAN @180
CBPB2_HUMAN	181	RRKR.\|.RSVA	inferred from experiment	unknown	MEROPS		Merops CBPB2_HUMAN -> FA10_HUMAN @181
CATG_HUMAN	215	NPFD.\|.DLLD	inferred from experiment	unknown	MEROPS	Altieri DC	Plescia J et al.:Activation of Mac-1 (CD11b/CD18... (S01.133)	8920993,
CATG_HUMAN	217	FDLL.\|.LDFN	inferred from experiment	unknown	MEROPS		Merops CATG_HUMAN -> FA10_HUMAN @217
KLK4_HUMAN	234	LTRI.\|.IVGG	inferred from experiment	unknown	MEROPS	Nelson PS	Matsumura M et al.:Substrates of the prostate-spec... (S01.251)	15389820,
FA7_HUMAN	234	LTRI.\|.IVGG	inferred from experiment	unknown	MEROPS		Merops FA7_HUMAN -> FA10_HUMAN @234
FA9_HUMAN	234	LTRI.\|.IVGG	inferred from experiment	unknown	MEROPS		Merops FA9_HUMAN -> FA10_HUMAN @234
PLMN_HUMAN	335	TFRM.\|.MNVA	inferred from experiment	unknown	MEROPS	Kessler GE	Pryzdial EL et al.:Plasmin converts factor X from ... (S01.233)	10085082,
PLMN_HUMAN	370	HEKG.\|.GRQS	inferred from experiment	unknown	MEROPS	Kessler GE	Pryzdial EL et al.:Plasmin converts factor X from ... (S01.233)	10085082,
FA10_HUMAN	372	KGRQ.\|.QSTR	inferred from experiment	unknown	MEROPS	Engh RA	Brandstetter H et al.:X-ray structure of active site-... (S01.216)	8939944,

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
PAR1_HUMAN	41	DPRS.\|.SFLL	inferred from experiment	unknown	MEROPS	Stone SR	Parry MA et al.:Cleavage of the thrombin recept... (S01.216)	8947506,
FA8_HUMAN	55	VPKS.\|.SFPF	inferred from experiment	unknown	MEROPS	Fay PJ	Nogami K et al.:Mechanisms of factor Xa-catalyz... (S01.216)	12606556,
PROS_HUMAN	101	AARQ.\|.QSTN	inferred from experiment	unknown	MEROPS	Griffin JH	Heeb MJ et al.:Activated protein C-dependent a... (S01.216)	12490286,
HGF_HUMAN	134	KGRS.\|.SYKG	inferred from experiment	unknown	MEROPS	Michalopoulos GK	Pediaditakis P et al.:Differential mitogenic effects ... (S01.216)	11832492,
HGF-Isoform6_HUMAN	134	KGRS.\|.SYKG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC9607
HGF-Isoform5_HUMAN	134	KGRS.\|.SYKG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC9607
HGF-Isoform4_HUMAN	134	KGRS.\|.SYKG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC9607
HGF-Isoform3_HUMAN	134	KGRS.\|.SYKG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC9607
HGF-Isoform2_HUMAN	134	KGRS.\|.SYKG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC9607
FA7-Isoform2_HUMAN	190	QGRI.\|.IVGG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC9601
FA7_HUMAN	212	QGRI.\|.IVGG	inferred from experiment	unknown	MEROPS		Merops FA10_HUMAN -> FA7_HUMAN @212
THRB_HUMAN	314	EGRT.\|.TATS	inferred from experiment	unknown	MEROPS	Engh RA	Brandstetter H et al.:X-ray structure of active site-... (S01.216)	8939944,
THRB_HUMAN	327	NPRT.\|.TFGS	inferred from experiment	unknown	MEROPS		Merops FA10_HUMAN -> THRB_HUMAN @327
APOH_HUMAN	336	FWKT.\|.TDAS	inferred from experiment	unknown	MEROPS	Kato H	Ohkura N et al.:Plasmin can reduce the function... (S01.216)	9596664,
FA8_HUMAN	355	QLRM.\|.MKNN	inferred from experiment	unknown	MEROPS	Fay PJ	Nogami K et al.:Mechanisms of factor Xa-catalyz... (S01.216)	12606556,
THRB_HUMAN	363	DGRI.\|.IVEG	inferred from experiment	unknown	MEROPS		Merops FA10_HUMAN -> THRB_HUMAN @363
FA10_HUMAN	372	KGRQ.\|.QSTR	inferred from experiment	unknown	MEROPS	Engh RA	Brandstetter H et al.:X-ray structure of active site-... (S01.216)	8939944,
FA8_HUMAN	391	QIRS.\|.SVAK	inferred from experiment	unknown	MEROPS	Fay PJ	Nogami K et al.:Mechanisms of factor Xa-catalyz... (S01.216)	12606556,
FA5_HUMAN	737	GIRS.\|.SFRN	inferred from experiment	unknown	MEROPS	Dahlback B	Thorelli E et al.:Cleavage requirements for activ... (S01.216)	9249003,
FA8_HUMAN	759	EPRS.\|.SFSQ	inferred from experiment	unknown	MEROPS	Fay PJ	Nogami K et al.:Mechanisms of factor Xa-catalyz... (S01.216)	12606556,
FA5_HUMAN	1046	SPRT.\|.TFHP	inferred from experiment	unknown	MEROPS	Dahlback B	Thorelli E et al.:Cleavage requirements for activ... (S01.216)	9249003,
FA5_HUMAN	1573	YLRS.\|.SNNG	inferred from experiment	unknown	MEROPS	Dahlback B	Thorelli E et al.:Cleavage requirements for activ... (S01.216)	9249003,
FA8_HUMAN	1708	SPRS.\|.SFQK	inferred from experiment	unknown	MEROPS	Fay PJ	Nogami K et al.:Mechanisms of factor Xa-catalyz... (S01.216)	12606556,
FA5_HUMAN	1793	SWRL.\|.LTSS	inferred from experiment	unknown	MEROPS	Dahlback B	Thorelli E et al.:Cleavage requirements for activ... (S01.216)	9249003,

TopFIND

P00742: Coagulation factor X

General Information

12

N-termini

10

C-termini

11

Cleavages

24

Substrates

Sequence

Isoforms

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Protein Neighborhood

Domains & Features

12 N-termini - 10 C-termini - 11 Cleavages - 24 Substrates

N-termini

C-termini

Cleavages

Substrates