P02749: Beta-2-glycoprotein 1

General Information

Protein names	- Beta-2-glycoprotein 1 - APC inhibitor - Activated protein C-binding protein - Anticardiolipin cofactor - Apolipoprotein H - Apo-H - Beta-2-glycoprotein I - B2GPI - Beta(2)GPI
Gene names	APOH
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P02749

3 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MISPVLILFS SFLCHVAIAG RTCPKPDDLP FSTVVPLKTF YEPGEEITYS CKPGYVSRGG
        70         80         90        100        110        120
MRKFICPLTG LWPINTLKCT PRVCPFAGIL ENGAVRYTTF EYPNTISFSC NTGFYLNGAD
       130        140        150        160        170        180
SAKCTEEGKW SPELPVCAPI ICPPPSIPTF ATLRVYKPSA GNNSLYRDTA VFECLPQHAM
       190        200        210        220        230        240
FGNDTITCTT HGNWTKLPEC REVKCPFPSR PDNGFVNYPA KPTLYYKDKA TFGCHDGYSL
       250        260        270        280        290        300
DGPEEIECTK LGNWSAMPSC KASCKVPVKK ATVVYQGERV KIQEKFKNGM LHGDKVSFFC
       310        320        330        340
KNKEKKCSYT EDAQCIDGTI EVPKCFKEHS SLAFWKTDAS DVKPC

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

3 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name	Publications (PMID)
P02749-20-unknown	GRTCPK...	20	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P02749-61-unknown	MRKFIC...	61	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000463553
P02749-337-unknown	TDASDV...	337	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27473
P02749-337-unknown	TDASDV...	337	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9599
P02749-337-unknown	TDASDV...	337	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9618
P02749-337-unknown	TDASDV...	337		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...QHAMFG	181	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000464301
...AMPSCK	260	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000463553
...LAFWKT	336	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27473
...LAFWKT	336	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9599
...LAFWKT	336	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9618
...DVKPC	345	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
PLMN_HUMAN	336	FWKT.\|.TDAS	inferred from experiment	unknown	MEROPS	Kato H	Ohkura N et al.:Plasmin can reduce the function... (S01.216)	9596664,
FA10_HUMAN	336	FWKT.\|.TDAS	inferred from experiment	unknown	MEROPS	Kato H	Ohkura N et al.:Plasmin can reduce the function... (S01.216)	9596664,
FA11_HUMAN	336	FWKT.\|.TDAS	inferred from experiment	unknown	MEROPS	Krilis SA	Shi T et al.:Domain V of beta2-glycoprotein ... (S01.213)	15522884,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)