P03951: Coagulation factor XI

General Information

Protein names	- Coagulation factor XI - FXI - 3.4.21.27 - Plasma thromboplastin antecedent - PTA - Coagulation factor XIa heavy chain - Coagulation factor XIa light chain
Gene names	F11
Organism	Homo sapiens
Protease Family	S01.213
Protease ID	S01.213
Chromosome location
UniProt ID	P03951

3 N-termini

2 C-termini

3 Cleavages

11 Substrates

Sequence

        10         20         30         40         50         60
MIFLYQVVHF ILFTSVSGEC VTQLLKDTCF EGGDITTVFT PSAKYCQVVC TYHPRCLLFT
        70         80         90        100        110        120
FTAESPSEDP TRWFTCVLKD SVTETLPRVN RTAAISGYSF KQCSHQISAC NKDIYVDLDM
       130        140        150        160        170        180
KGINYNSSVA KSAQECQERC TDDVHCHFFT YATRQFPSLE HRNICLLKHT QTGTPTRITK
       190        200        210        220        230        240
LDKVVSGFSL KSCALSNLAC IRDIFPNTVF ADSNIDSVMA PDAFVCGRIC THHPGCLFFT
       250        260        270        280        290        300
FFSQEWPKES QRNLCLLKTS ESGLPSTRIK KSKALSGFSL QSCRHSIPVF CHSSFYHDTD
       310        320        330        340        350        360
FLGEELDIVA AKSHEACQKL CTNAVRCQFF TYTPAQASCN EGKGKCYLKL SSNGSPTKIL
       370        380        390        400        410        420
HGRGGISGYT LRLCKMDNEC TTKIKPRIVG GTASVRGEWP WQVTLHTTSP TQRHLCGGSI
       430        440        450        460        470        480
IGNQWILTAA HCFYGVESPK ILRVYSGILN QSEIKEDTSF FGVQEIIIHD QYKMAESGYD
       490        500        510        520        530        540
IALLKLETTV NYTDSQRPIC LPSKGDRNVI YTDCWVTGWG YRKLRDKIQN TLQKAKIPLV
       550        560        570        580        590        600
TNEECQKRYR GHKITHKMIC AGYREGGKDA CKGDSGGPLS CKHNEVWHLV GITSWGEGCA
       610        620
QRERPGVYTN VVEYVDWILE KTQAV

Isoforms

- Isoform 2 of Coagulation factor XI

Sequence View

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Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 3 Cleavages - 11 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P03951-1-unknown	MIFLYQ...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt74604
P03951-19-unknown	ECVTQL...	19	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P03951-19-unknown	ECVTQL...	19	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112129
P03951-388-unknown	IVGGTA...	388	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P03951-388-unknown	IVGGTA...	388	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9619
P03951-388-unknown	IVGGTA...	388	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9628
P03951-388-unknown	IVGGTA...	388	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31743
P03951-388-unknown	IVGGTA...	388	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116192

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KIKPRI	387	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...KIKPRI	387	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9619
...KIKPRI	387	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9628
...KIKPRI	387	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31743
...KIKPRI	387	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92626
...KTQAV	625	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...KTQAV	625	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt70222

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
FA11_HUMAN	387	KPRI.\|.IVGG	inferred from experiment	unknown	MEROPS	Fujikawa K	Naito K et al.:Activation of human blood coagu... (S01.213)	2019570,
FA12_HUMAN	387	KPRI.\|.IVGG	inferred from experiment	unknown	MEROPS		Merops FA12_HUMAN -> FA11_HUMAN @387
THRB_HUMAN	387	KPRI.\|.IVGG	inferred from experiment	unknown	MEROPS	Fujikawa K	Naito K et al.:Activation of human blood coagu... (S01.213)	2019570,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
FA9-Isoform2_HUMAN	153	LTRA.\|.AETV	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC9614
FA9-Isoform2_HUMAN	188	FTRV.\|.VVGG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC9616
FA9_HUMAN	191	LTRA.\|.AETV	inferred from experiment	unknown	MEROPS		Merops FA11_HUMAN -> FA9_HUMAN @191
FA9_HUMAN	226	FTRV.\|.VVGG	inferred from experiment	unknown	MEROPS		Merops FA11_HUMAN -> FA9_HUMAN @226
FA11-Isoform2_HUMAN	333	KPRI.\|.IVGG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC9619
APOH_HUMAN	336	FWKT.\|.TDAS	inferred from experiment	unknown	MEROPS	Krilis SA	Shi T et al.:Domain V of beta2-glycoprotein ... (S01.213)	15522884,
FA11_HUMAN	387	KPRI.\|.IVGG	inferred from experiment	unknown	MEROPS	Fujikawa K	Naito K et al.:Activation of human blood coagu... (S01.213)	2019570,
HGF-Isoform3_HUMAN	419	LHRH.\|.HIFW	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC9621
HGF_HUMAN	424	LHRH.\|.HIFW	inferred from experiment	unknown	MEROPS	Kirchhofer D	Peek M et al.:Unusual proteolytic activation ... (S01.213)	12372819,
HGF-Isoform3_HUMAN	489	QLRV.\|.VVNG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC9623
HGF_HUMAN	494	QLRV.\|.VVNG	inferred from experiment	unknown	MEROPS	Kirchhofer D	Peek M et al.:Unusual proteolytic activation ... (S01.213)	12372819,