P25116: Proteinase-activated receptor 1

General Information

Protein names	- Proteinase-activated receptor 1 - PAR-1 - Coagulation factor II receptor - Thrombin receptor
Gene names	F2R
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P25116

21 N-termini

22 C-termini

43 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MGPRRLLLVA ACFSLCGPLL SARTRARRPE SKATNATLDP RSFLLRNPND KYEPFWEDEE
        70         80         90        100        110        120
KNESGLTEYR LVSINKSSPL QKQLPAFISE DASGYLTSSW LTLFVPSVYT GVFVVSLPLN
       130        140        150        160        170        180
IMAIVVFILK MKVKKPAVVY MLHLATADVL FVSVLPFKIS YYFSGSDWQF GSELCRFVTA
       190        200        210        220        230        240
AFYCNMYASI LLMTVISIDR FLAVVYPMQS LSWRTLGRAS FTCLAIWALA IAGVVPLLLK
       250        260        270        280        290        300
EQTIQVPGLN ITTCHDVLNE TLLEGYYAYY FSAFSAVFFF VPLIISTVCY VSIIRCLSSS
       310        320        330        340        350        360
AVANRSKKSR ALFLSAAVFC IFIICFGPTN VLLIAHYSFL SHTSTTEAAY FAYLLCVCVS
       370        380        390        400        410        420
SISCCIDPLI YYYASSECQR YVYSILCCKE SSDPSSYNSS GQLMASKMDT CSSNLNNSIY

KKLLT

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

21 N-termini - 22 C-termini - 43 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P25116-26-unknown	ARRPES...	26	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31775
P25116-33-unknown	ATNATL...	33	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27572
P25116-33-unknown	ATNATL...	33	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC748
P25116-37-unknown	TLDPRS...	37	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27785
P25116-37-unknown	TLDPRS...	37	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9393
P25116-42-unknown	SFLLRN...	42	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P25116-42-unknown	SFLLRN...	42	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21762
P25116-42-unknown	SFLLRN...	42	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31776
P25116-42-unknown	SFLLRN...	42	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10040
P25116-42-unknown	SFLLRN...	42	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16462
P25116-42-unknown	SFLLRN...	42	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11353
P25116-42-unknown	SFLLRN...	42	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15990
P25116-42-unknown	SFLLRN...	42	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27769
P25116-42-unknown	SFLLRN...	42	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9613
P25116-42-unknown	SFLLRN...	42	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9394
P25116-42-unknown	SFLLRN...	42	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27573
P25116-42-unknown	SFLLRN...	42	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31962
P25116-42-unknown	SFLLRN...	42	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31972
P25116-42-unknown	SFLLRN...	42	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16617
P25116-42-unknown	SFLLRN...	42	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4843
P25116-43-unknown	FLLRNP...	43	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16618
P25116-44-unknown	LLRNPN...	44	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16463
P25116-44-unknown	LLRNPN...	44	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15991
P25116-44-unknown	LLRNPN...	44	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16619
P25116-44-unknown	LLRNPN...	44	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4844
P25116-45-unknown	LRNPND...	45	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4845
P25116-46-unknown	RNPNDK...	46	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16620
P25116-47-unknown	NPNDKY...	47	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15992
P25116-47-unknown	NPNDKY...	47	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31973
P25116-47-unknown	NPNDKY...	47	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16621
P25116-49-unknown	NDKYEP...	49	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27786
P25116-52-unknown	YEPFWE...	52	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31974
P25116-55-unknown	FWEDEE...	55	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27787
P25116-56-unknown	WEDEEK...	56	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4846
P25116-70-unknown	RLVSIN...	70	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4847
P25116-71-unknown	LVSINK...	71	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27574
P25116-73-unknown	SINKSS...	73	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27788
P25116-73-unknown	SINKSS...	73	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9395
P25116-75-unknown	NKSSPL...	75	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9396
P25116-77-unknown	SSPLQK...	77	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27575
P25116-77-unknown	SSPLQK...	77	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC749
P25116-83-unknown	QLPAFI...	83	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27576
P25116-87-unknown	FISEDA...	87	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9397
P25116-93-unknown	SGYLTS...	93	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27789

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SARTRA	25	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31775
...RPESKA	32	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27572
...RPESKA	32	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC748
...KATNAT	36	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27785
...KATNAT	36	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9393
...TLDPRS	41	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21762
...TLDPRS	41	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31776
...TLDPRS	41	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10040
...TLDPRS	41	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16462
...TLDPRS	41	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11353
...TLDPRS	41	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15990
...TLDPRS	41	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27769
...TLDPRS	41	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9613
...TLDPRS	41	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9394
...TLDPRS	41	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27573
...TLDPRS	41	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31962
...TLDPRS	41	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31972
...TLDPRS	41	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16617
...TLDPRS	41	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4843
...LDPRSF	42	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16618
...DPRSFL	43	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16463
...DPRSFL	43	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15991
...DPRSFL	43	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16619
...DPRSFL	43	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4844
...PRSFLL	44	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4845
...RSFLLR	45	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16620
...SFLLRN	46	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15992
...SFLLRN	46	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31973
...SFLLRN	46	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16621
...LLRNPN	48	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27786
...NPNDKY	51	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31974
...DKYEPF	54	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27787
...KYEPFW	55	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4846
...GLTEYR	69	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4847
...LTEYRL	70	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27574
...EYRLVS	72	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27788
...EYRLVS	72	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9395
...RLVSIN	74	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9396
...VSINKS	76	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27575
...VSINKS	76	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC749
...SPLQKQ	82	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27576
...KQLPAF	86	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9397
...ISEDAS	92	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27789
...KKLLT	425	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
THRB_HUMAN	25	RTRA.\|.ARRP	inferred from experiment	unknown	MEROPS	Lanza F	Loew D et al.:Proteolysis of the exodomain of... (S01.133)	10978167,
PLMN_HUMAN	32	ESKA.\|.ATNA	inferred from experiment	unknown	MEROPS	Lanza F	Loew D et al.:Proteolysis of the exodomain of... (S01.133)	10978167,
CAN1_HUMAN	32	ESKA.\|.ATNA	inferred from experiment	unknown	MEROPS	Lanza F	Loew D et al.:Proteolysis of the exodomain of... (C02.001)	10978167,
PRTN3_HUMAN	36	TNAT.\|.TLDP	inferred from experiment	unknown	MEROPS	Lanza F	Loew D et al.:Proteolysis of the exodomain of... (S01.133)	10978167,
ELNE_HUMAN	36	TNAT.\|.TLDP	inferred from experiment	unknown	MEROPS	Lanza F	Loew D et al.:Proteolysis of the exodomain of... (S01.133)	10978167,
MMP1_HUMAN	41	DPRS.\|.SFLL	inferred from experiment	unknown	MEROPS	Kuliopulos A	Boire A et al.:PAR1 is a matrix metalloproteas... (M10.001)	15707890,
THRB_HUMAN	41	DPRS.\|.SFLL	inferred from experiment	unknown	MEROPS	Lanza F	Loew D et al.:Proteolysis of the exodomain of... (S01.133)	10978167,
GRAA_HUMAN	41	DPRS.\|.SFLL	inferred from experiment	unknown	MEROPS		Merops GRAA_HUMAN -> PAR1_HUMAN @41
KLK5_HUMAN	41	DPRS.\|.SFLL	inferred from experiment	unknown	MEROPS	Hollenberg MD	Oikonomopoulou K et al.:Proteinase-activated receptors,... (S01.029)	16885167,
GRAB_HUMAN	41	DPRS.\|.SFLL	inferred from experiment	unknown	MEROPS	Stone SR	Parry MA et al.:Cleavage of the thrombin recept... (S01.216)	8947506,
KLK14_HUMAN	41	DPRS.\|.SFLL	inferred from experiment	unknown	MEROPS	Hollenberg MD	Oikonomopoulou K et al.:Proteinase-activated receptors,... (S01.029)	16885167,
PROC_HUMAN	41	DPRS.\|.SFLL	inferred from experiment	unknown	MEROPS	Stone SR	Parry MA et al.:Cleavage of the thrombin recept... (S01.216)	8947506,
FA10_HUMAN	41	DPRS.\|.SFLL	inferred from experiment	unknown	MEROPS	Stone SR	Parry MA et al.:Cleavage of the thrombin recept... (S01.216)	8947506,
ELNE_HUMAN	41	DPRS.\|.SFLL	inferred from experiment	unknown	MEROPS		Merops ELNE_HUMAN -> PAR1_HUMAN @41
PLMN_HUMAN	41	DPRS.\|.SFLL	inferred from experiment	unknown	MEROPS	Lanza F	Loew D et al.:Proteolysis of the exodomain of... (S01.133)	10978167,
TRY3_HUMAN	41	DPRS.\|.SFLL	inferred from experiment	unknown	MEROPS	Bunnett NW	Knecht W et al.:Trypsin IV or mesotrypsin and p... (S01.156)	17623652,
TRYB1_HUMAN	41	DPRS.\|.SFLL	inferred from experiment	unknown	MEROPS	Brass LF	Molino M et al.:Interactions of mast cell trypt... (S01.143)	9020112,
KLK6_HUMAN	41	DPRS.\|.SFLL	inferred from experiment	unknown	MEROPS	Hollenberg MD	Oikonomopoulou K et al.:Proteinase-activated receptors,... (S01.029)	16885167,
CATG_HUMAN	41	DPRS.\|.SFLL	inferred from experiment	unknown	MEROPS	Lanza F	Loew D et al.:Proteolysis of the exodomain of... (S01.133)	10978167,
KLK6_HUMAN	42	PRSF.\|.FLLR	inferred from experiment	unknown	MEROPS	Hollenberg MD	Oikonomopoulou K et al.:Proteinase-activated receptors,... (S01.029)	16885167,
KLK5_HUMAN	43	RSFL.\|.LLRN	inferred from experiment	unknown	MEROPS	Hollenberg MD	Oikonomopoulou K et al.:Proteinase-activated receptors,... (S01.029)	16885167,
KLK14_HUMAN	43	RSFL.\|.LLRN	inferred from experiment	unknown	MEROPS	Hollenberg MD	Oikonomopoulou K et al.:Proteinase-activated receptors,... (S01.029)	16885167,
KLK6_HUMAN	43	RSFL.\|.LLRN	inferred from experiment	unknown	MEROPS	Hollenberg MD	Oikonomopoulou K et al.:Proteinase-activated receptors,... (S01.029)	16885167,
CATG_HUMAN	43	RSFL.\|.LLRN	inferred from experiment	unknown	MEROPS	Lanza F	Loew D et al.:Proteolysis of the exodomain of... (S01.133)	10978167,
CATG_HUMAN	44	SFLL.\|.LRNP	inferred from experiment	unknown	MEROPS	Steinberg SF	Steinberg SF et al.:The cardiovascular actions of p... (S01.133)	15371558,
KLK6_HUMAN	45	FLLR.\|.RNPN	inferred from experiment	unknown	MEROPS	Hollenberg MD	Oikonomopoulou K et al.:Proteinase-activated receptors,... (S01.029)	16885167,
KLK14_HUMAN	46	LLRN.\|.NPND	inferred from experiment	unknown	MEROPS	Hollenberg MD	Oikonomopoulou K et al.:Proteinase-activated receptors,... (S01.029)	16885167,
TRYB1_HUMAN	46	LLRN.\|.NPND	inferred from experiment	unknown	MEROPS	Brass LF	Molino M et al.:Interactions of mast cell trypt... (S01.143)	9020112,
KLK6_HUMAN	46	LLRN.\|.NPND	inferred from experiment	unknown	MEROPS	Hollenberg MD	Oikonomopoulou K et al.:Proteinase-activated receptors,... (S01.029)	16885167,
PRTN3_HUMAN	48	RNPN.\|.NDKY	inferred from experiment	unknown	MEROPS	Lanza F	Loew D et al.:Proteolysis of the exodomain of... (S01.133)	10978167,
TRYB1_HUMAN	51	NDKY.\|.YEPF	inferred from experiment	unknown	MEROPS	Brass LF	Molino M et al.:Interactions of mast cell trypt... (S01.143)	9020112,
PRTN3_HUMAN	54	YEPF.\|.FWED	inferred from experiment	unknown	MEROPS	Lanza F	Loew D et al.:Proteolysis of the exodomain of... (S01.133)	10978167,
CATG_HUMAN	55	EPFW.\|.WEDE	inferred from experiment	unknown	MEROPS	Lanza F	Loew D et al.:Proteolysis of the exodomain of... (S01.133)	10978167,
CATG_HUMAN	69	TEYR.\|.RLVS	inferred from experiment	unknown	MEROPS	Lanza F	Loew D et al.:Proteolysis of the exodomain of... (S01.133)	10978167,
PLMN_HUMAN	70	EYRL.\|.LVSI	inferred from experiment	unknown	MEROPS	Lanza F	Loew D et al.:Proteolysis of the exodomain of... (S01.133)	10978167,
PRTN3_HUMAN	72	RLVS.\|.SINK	inferred from experiment	unknown	MEROPS	Lanza F	Loew D et al.:Proteolysis of the exodomain of... (S01.133)	10978167,
ELNE_HUMAN	72	RLVS.\|.SINK	inferred from experiment	unknown	MEROPS	Lanza F	Loew D et al.:Proteolysis of the exodomain of... (S01.133)	10978167,
ELNE_HUMAN	74	VSIN.\|.NKSS	inferred from experiment	unknown	MEROPS	Chignard M	Renesto P et al.:Specific inhibition of thrombin... (S01.131)	9058715,
PLMN_HUMAN	76	INKS.\|.SSPL	inferred from experiment	unknown	MEROPS	Lanza F	Loew D et al.:Proteolysis of the exodomain of... (S01.133)	10978167,
CAN1_HUMAN	76	INKS.\|.SSPL	inferred from experiment	unknown	MEROPS	Lanza F	Loew D et al.:Proteolysis of the exodomain of... (C02.001)	10978167,
PLMN_HUMAN	82	LQKQ.\|.QLPA	inferred from experiment	unknown	MEROPS	Steinberg SF	Steinberg SF et al.:The cardiovascular actions of p... (S01.133)	15371558,
ELNE_HUMAN	86	LPAF.\|.FISE	inferred from experiment	unknown	MEROPS	Lanza F	Loew D et al.:Proteolysis of the exodomain of... (S01.133)	10978167,
PRTN3_HUMAN	92	EDAS.\|.SGYL	inferred from experiment	unknown	MEROPS	Lanza F	Loew D et al.:Proteolysis of the exodomain of... (S01.133)	10978167,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)