P35030: Trypsin-3
Protein names | - Trypsin-3 - 3.4.21.4 {ECO:0000269|PubMed:11827488, ECO:0000269|PubMed:14507909, ECO:0000269|PubMed:18077447, ECO:0000269|PubMed:25301953, ECO:0000269|PubMed:27810896, ECO:0000269|PubMed:6698368, ECO:0000269|PubMed:9099703} - Brain trypsinogen {ECO:0000303|PubMed:8294000} - Mesotrypsin {ECO:0000303|PubMed:14507909} - Mesotrypsinogen {ECO:0000303|PubMed:9099703} - Serine protease 3 - Serine protease 4 - Trypsin III - Trypsin IV {ECO:0000303|PubMed:8294000} |
---|---|
Gene names | PRSS3 |
Organism | Homo sapiens |
Protease Family | S01.174 |
Protease ID | S01.174 |
Chromosome location | |
UniProt ID | P35030 |
2
N-termini
3
C-termini
1
Cleavages
37
Substrates
Sequence
10 20 30 40 50 60
MCGPDDRCPA RWPGPGRAVK CGKGLAAARP GRVERGGAQR GGAGLELHPL LGGRTWRAAR
70 80 90 100 110 120
DADGCEALGT VAVPFDDDDK IVGGYTCEEN SLPYQVSLNS GSHFCGGSLI SEQWVVSAAH
130 140 150 160 170 180
CYKTRIQVRL GEHNIKVLEG NEQFINAAKI IRHPKYNRDT LDNDIMLIKL SSPAVINARV
190 200 210 220 230 240
STISLPTTPP AAGTECLISG WGNTLSFGAD YPDELKCLDA PVLTQAECKA SYPGKITNSM
250 260 270 280 290 300
FCVGFLEGGK DSCQRDSGGP VVCNGQLQGV VSWGHGCAWK NRPGVYTKVY NYVDWIKDTI
AANS
Isoforms
- Isoform 2 of Trypsin-3 - Isoform 3 of Trypsin-3 - Isoform 4 of Trypsin-3 - Isoform 5 of Trypsin-3Sequence View
10 20 30 40 50 60
MCGPDDRCPA RWPGPGRAVK CGKGLAAARP GRVERGGAQR GGAGLELHPL LGGRTWRAAR
70 80 90 100 110 120
DADGCEALGT VAVPFDDDDK IVGGYTCEEN SLPYQVSLNS GSHFCGGSLI SEQWVVSAAH
130 140 150 160 170 180
CYKTRIQVRL GEHNIKVLEG NEQFINAAKI IRHPKYNRDT LDNDIMLIKL SSPAVINARV
190 200 210 220 230 240
STISLPTTPP AAGTECLISG WGNTLSFGAD YPDELKCLDA PVLTQAECKA SYPGKITNSM
250 260 270 280 290 300
FCVGFLEGGK DSCQRDSGGP VVCNGQLQGV VSWGHGCAWK NRPGVYTKVY NYVDWIKDTI
AANS
10 20 30 40 50 60
MCGPDDRCPA RWPGPGRAVK CGKGLAAARP GRVERGGAQR GGAGLELHPL LGGRTWRAAR
70 80 90 100 110 120
DADGCEALGT VAVPFDDDDK IVGGYTCEEN SLPYQVSLNS GSHFCGGSLI SEQWVVSAAH
130 140 150 160 170 180
CYKTRIQVRL GEHNIKVLEG NEQFINAAKI IRHPKYNRDT LDNDIMLIKL SSPAVINARV
190 200 210 220 230 240
STISLPTTPP AAGTECLISG WGNTLSFGAD YPDELKCLDA PVLTQAECKA SYPGKITNSM
250 260 270 280 290 300
FCVGFLEGGK DSCQRDSGGP VVCNGQLQGV VSWGHGCAWK NRPGVYTKVY NYVDWIKDTI
AANS
10 20 30 40 50 60
MCGPDDRCPA RWPGPGRAVK CGKGLAAARP GRVERGGAQR GGAGLELHPL LGGRTWRAAR
70 80 90 100 110 120
DADGCEALGT VAVPFDDDDK IVGGYTCEEN SLPYQVSLNS GSHFCGGSLI SEQWVVSAAH
130 140 150 160 170 180
CYKTRIQVRL GEHNIKVLEG NEQFINAAKI IRHPKYNRDT LDNDIMLIKL SSPAVINARV
190 200 210 220 230 240
STISLPTTPP AAGTECLISG WGNTLSFGAD YPDELKCLDA PVLTQAECKA SYPGKITNSM
250 260 270 280 290 300
FCVGFLEGGK DSCQRDSGGP VVCNGQLQGV VSWGHGCAWK NRPGVYTKVY NYVDWIKDTI
AANS
10 20 30 40 50 60
MCGPDDRCPA RWPGPGRAVK CGKGLAAARP GRVERGGAQR GGAGLELHPL LGGRTWRAAR
70 80 90 100 110 120
DADGCEALGT VAVPFDDDDK IVGGYTCEEN SLPYQVSLNS GSHFCGGSLI SEQWVVSAAH
130 140 150 160 170 180
CYKTRIQVRL GEHNIKVLEG NEQFINAAKI IRHPKYNRDT LDNDIMLIKL SSPAVINARV
190 200 210 220 230 240
STISLPTTPP AAGTECLISG WGNTLSFGAD YPDELKCLDA PVLTQAECKA SYPGKITNSM
250 260 270 280 290 300
FCVGFLEGGK DSCQRDSGGP VVCNGQLQGV VSWGHGCAWK NRPGVYTKVY NYVDWIKDTI
AANS
Protein Neighborhood
Domains & Features
2 N-termini - 3 C-termini - 1 Cleavages - 37 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
P35030-1-unknown | MCGPDD... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
P35030-81-unknown | IVGGYT... | 81 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
P35030-81-unknown | IVGGYT... | 81 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC9541 | |||
P35030-81-unknown | IVGGYT... | 81 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt115812 | |||
P35030-81-unknown | IVGGYT... | 81 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt115814 | |||
P35030-81-unknown | IVGGYT... | 81 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt115815 | |||
P35030-81-unknown | IVGGYT... | 81 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt115813 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...DDDDKI | 80 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC9541 | |||
...DDDDKI | 80 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt121117 | |||
...LDAPVL | 222 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000401249 | |||
...IAANS | 304 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...IAANS | 304 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt88854 | |||
...IAANS | 304 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt88852 | |||
...IAANS | 304 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt88851 | |||
...IAANS | 304 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt88853 |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
ENTK_HUMAN | 80 | DDKI.|.IVGG | inferred from experiment | unknown | MEROPS | Bunnett NW | Knecht W et al.:Trypsin IV or mesotrypsin and p... (S01.156) | 17623652, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
MBP-Isoform6_HUMAN | 26 | HARH.|.HGFL | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC31936 | ||
MBP-Isoform5_HUMAN | 26 | HARH.|.HGFL | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC31936 | ||
MBP-Isoform4_HUMAN | 26 | HARH.|.HGFL | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC31936 | ||
MBP-Isoform3_HUMAN | 26 | HARH.|.HGFL | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC31936 | ||
ISK1_HUMAN | 28 | LGRE.|.EAKC | inferred from experiment | unknown | MEROPS | Sahin-Toth M | Szmola R et al.:Human mesotrypsin is a unique d... (S01.174) | 14507909, |
A1AT-Isoform3_HUMAN | 34 | AQKT.|.TDTS | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC31932 | ||
A1AT-Isoform2_HUMAN | 34 | AQKT.|.TDTS | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC31932 | ||
A1AT_HUMAN | 34 | AQKT.|.TDTS | inferred from experiment | unknown | MEROPS | Sahin-Toth M | Szepessy E et al.:Human mesotrypsin exhibits rest... (S01.174) | 16759229, |
PAR2_HUMAN | 36 | KGRS.|.SLIG | inferred from experiment | unknown | MEROPS | Bunnett NW | Knecht W et al.:Trypsin IV or mesotrypsin and p... (S01.174) | 17623652, |
PAR1_HUMAN | 41 | DPRS.|.SFLL | inferred from experiment | unknown | MEROPS | Bunnett NW | Knecht W et al.:Trypsin IV or mesotrypsin and p... (S01.156) | 17623652, |
ISK1_HUMAN | 41 | CTKI.|.IYDP | inferred from experiment | unknown | MEROPS | Sahin-Toth M | Szmola R et al.:Human mesotrypsin is a unique d... (S01.174) | 14507909, |
PAR4_HUMAN | 47 | APRG.|.GYPG | inferred from experiment | unknown | MEROPS | Bunnett NW | Knecht W et al.:Trypsin IV or mesotrypsin and p... (S01.156) | 17623652, |
MBP-Isoform6_HUMAN | 66 | PART.|.TAHY | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC31942 | ||
MBP-Isoform5_HUMAN | 66 | PART.|.TAHY | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC31942 | ||
ISK1_HUMAN | 67 | RKRQ.|.QTSI | inferred from experiment | unknown | MEROPS | Sahin-Toth M | Szmola R et al.:Human mesotrypsin is a unique d... (S01.174) | 14507909, |
ISK1_HUMAN | 75 | IQKS.|.SGPC | inferred from experiment | unknown | MEROPS | Sahin-Toth M | Szmola R et al.:Human mesotrypsin is a unique d... (S01.174) | 14507909, |
MBP-Isoform6_HUMAN | 80 | HGRT.|.TQDE | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC31945 | ||
MBP-Isoform5_HUMAN | 80 | HGRT.|.TQDE | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC31945 | ||
MBP-Isoform5_HUMAN | 98 | TPRT.|.TPPP | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC31950 | ||
MBP-Isoform4_HUMAN | 106 | HGRT.|.TQDE | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC31945 | ||
MBP-Isoform3_HUMAN | 106 | HGRT.|.TQDE | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC31945 | ||
MBP-Isoform5_HUMAN | 108 | KGRG.|.GLSL | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC31953 | ||
TRY1_HUMAN | 122 | NARV.|.VSTI | inferred from experiment | unknown | MEROPS | Sahin-Toth M | Szmola R et al.:Human mesotrypsin is a unique d... (S01.174) | 14507909, |
MBP-Isoform3_HUMAN | 124 | TPRT.|.TPPP | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC31950 | ||
MBP-Isoform3_HUMAN | 134 | KGRG.|.GLSL | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC31953 | ||
MBP_HUMAN | 159 | HARH.|.HGFL | inferred from experiment | unknown | MEROPS | Graf L | Medveczky P et al.:Myelin basic protein, an autoan... (C02.002) | 16412431, |
MBP-Isoform2_HUMAN | 159 | HARH.|.HGFL | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC31936 | ||
MBP_HUMAN | 199 | PART.|.TAHY | inferred from experiment | unknown | MEROPS | Graf L | Medveczky P et al.:Myelin basic protein, an autoan... (C02.002) | 16412431, |
MBP_HUMAN | 213 | HGRT.|.TQDE | inferred from experiment | unknown | MEROPS | Graf L | Medveczky P et al.:Myelin basic protein, an autoan... (C02.002) | 16412431, |
MBP_HUMAN | 231 | TPRT.|.TPPP | inferred from experiment | unknown | MEROPS | Graf L | Medveczky P et al.:Myelin basic protein, an autoan... (C02.002) | 16412431, |
MBP_HUMAN | 241 | KGRG.|.GLSL | inferred from experiment | unknown | MEROPS | Graf L | Medveczky P et al.:Myelin basic protein, an autoan... (C02.002) | 16412431, |
A4-Isoform11_HUMAN | 296 | PCRA.|.AMIS | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC31956 | ||
A4-Isoform9_HUMAN | 301 | PCRA.|.AMIS | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC31956 | ||
A4-Isoform8_HUMAN | 301 | PCRA.|.AMIS | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC31956 | ||
A4-Isoform7_HUMAN | 301 | PCRA.|.AMIS | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC31956 | ||
A4_HUMAN | 301 | PCRA.|.AMIS | inferred from experiment | unknown | MEROPS | Radisky ES | Salameh MA et al.:The amyloid precursor protein/p... (S01.174) | 19920152, |
A1AT_HUMAN | 382 | IPMS.|.SIPP | inferred from experiment | unknown | MEROPS | Sahin-Toth M | Szepessy E et al.:Human mesotrypsin exhibits rest... (S01.174) | 16759229, |