Q96RI0: Proteinase-activated receptor 4

General Information

Protein names	- Proteinase-activated receptor 4 - PAR-4 - Coagulation factor II receptor-like 3 - Thrombin receptor-like 3
Gene names	F2RL3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q96RI0

9 N-termini

9 C-termini

17 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MWGRLLLWPL VLGFSLSGGT QTPSVYDESG STGGGDDSTP SILPAPRGYP GQVCANDSDT
        70         80         90        100        110        120
LELPDSSRAL LLGWVPTRLV PALYGLVLVV GLPANGLALW VLATQAPRLP STMLLMNLAA
       130        140        150        160        170        180
ADLLLALALP PRIAYHLRGQ RWPFGEAACR LATAALYGHM YGSVLLLAAV SLDRYLALVH
       190        200        210        220        230        240
PLRARALRGR RLALGLCMAA WLMAAALALP LTLQRQTFRL ARSDRVLCHD ALPLDAQASH
       250        260        270        280        290        300
WQPAFTCLAL LGCFLPLLAM LLCYGATLHT LAASGRRYGH ALRLTAVVLA SAVAFFVPSN
       310        320        330        340        350        360
LLLLLHYSDP SPSAWGNLYG AYVPSLALST LNSCVDPFIY YYVSAEFRDK VRAGLFQRSP
       370        380
GDTVASKASA EGGSRGMGTH SSLLQ

Isoforms

Sequence View

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q96RI0-18-unknown	GGTQTP...	18	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q96RI0-36-unknown	DDSTPS...	36	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16478
Q96RI0-36-unknown	DDSTPS...	36	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16000
Q96RI0-36-unknown	DDSTPS...	36	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16630
Q96RI0-37-unknown	DSTPSI...	37	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16479
Q96RI0-38-unknown	STPSIL...	38	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16480
Q96RI0-40-unknown	PSILPA...	40	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16631
Q96RI0-41-unknown	SILPAP...	41	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16632
Q96RI0-48-unknown	GYPGQV...	48	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q96RI0-48-unknown	GYPGQV...	48	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31821
Q96RI0-48-unknown	GYPGQV...	48	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4953
Q96RI0-48-unknown	GYPGQV...	48	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16481
Q96RI0-48-unknown	GYPGQV...	48	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16001
Q96RI0-48-unknown	GYPGQV...	48	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27604
Q96RI0-48-unknown	GYPGQV...	48	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31964
Q96RI0-48-unknown	GYPGQV...	48	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16633
Q96RI0-48-unknown	GYPGQV...	48	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
Q96RI0-50-unknown	PGQVCA...	50	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16002
Q96RI0-50-unknown	PGQVCA...	50	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16634
Q96RI0-52-unknown	QVCAND...	52	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16482

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...STGGGD	35	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16478
...STGGGD	35	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16000
...STGGGD	35	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16630
...TGGGDD	36	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16479
...GGGDDS	37	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16480
...GDDSTP	39	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16631
...DDSTPS	40	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16632
...LPAPRG	47	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31821
...LPAPRG	47	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4953
...LPAPRG	47	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16481
...LPAPRG	47	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16001
...LPAPRG	47	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27604
...LPAPRG	47	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31964
...LPAPRG	47	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16633
...APRGYP	49	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16002
...APRGYP	49	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16634
...RGYPGQ	51	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16482
...SSLLQ	385	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
KLK5_HUMAN	35	GGGD.\|.DDST	inferred from experiment	unknown	MEROPS	Hollenberg MD	Oikonomopoulou K et al.:Proteinase-activated receptors,... (S01.029)	16885167,
KLK14_HUMAN	35	GGGD.\|.DDST	inferred from experiment	unknown	MEROPS	Hollenberg MD	Oikonomopoulou K et al.:Proteinase-activated receptors,... (S01.029)	16885167,
KLK6_HUMAN	35	GGGD.\|.DDST	inferred from experiment	unknown	MEROPS	Hollenberg MD	Oikonomopoulou K et al.:Proteinase-activated receptors,... (S01.029)	16885167,
KLK5_HUMAN	36	GGDD.\|.DSTP	inferred from experiment	unknown	MEROPS	Hollenberg MD	Oikonomopoulou K et al.:Proteinase-activated receptors,... (S01.029)	16885167,
KLK5_HUMAN	37	GDDS.\|.STPS	inferred from experiment	unknown	MEROPS	Hollenberg MD	Oikonomopoulou K et al.:Proteinase-activated receptors,... (S01.029)	16885167,
KLK6_HUMAN	39	DSTP.\|.PSIL	inferred from experiment	unknown	MEROPS	Hollenberg MD	Oikonomopoulou K et al.:Proteinase-activated receptors,... (S01.029)	16885167,
KLK6_HUMAN	40	STPS.\|.SILP	inferred from experiment	unknown	MEROPS	Hollenberg MD	Oikonomopoulou K et al.:Proteinase-activated receptors,... (S01.029)	16885167,
THRB_HUMAN	47	APRG.\|.GYPG	inferred from experiment	unknown	MEROPS	Kuwano K	Kida Y et al.:A novel secreted protease from ... (S01.217)	18331590,
CATG_HUMAN	47	APRG.\|.GYPG	inferred from experiment	unknown	MEROPS	Coughlin SR	Sambrano GR et al.:Cathepsin G activates protease-... (S01.133)	10702240,
KLK5_HUMAN	47	APRG.\|.GYPG	inferred from experiment	unknown	MEROPS	Hollenberg MD	Oikonomopoulou K et al.:Proteinase-activated receptors,... (S01.029)	16885167,
KLK14_HUMAN	47	APRG.\|.GYPG	inferred from experiment	unknown	MEROPS	Hollenberg MD	Oikonomopoulou K et al.:Proteinase-activated receptors,... (S01.029)	16885167,
PLMN_HUMAN	47	APRG.\|.GYPG	inferred from experiment	unknown	MEROPS	Steinberg SF	Steinberg SF et al.:The cardiovascular actions of p... (S01.133)	15371558,
TRY3_HUMAN	47	APRG.\|.GYPG	inferred from experiment	unknown	MEROPS	Bunnett NW	Knecht W et al.:Trypsin IV or mesotrypsin and p... (S01.156)	17623652,
KLK6_HUMAN	47	APRG.\|.GYPG	inferred from experiment	unknown	MEROPS	Hollenberg MD	Oikonomopoulou K et al.:Proteinase-activated receptors,... (S01.029)	16885167,
KLK14_HUMAN	49	RGYP.\|.PGQV	inferred from experiment	unknown	MEROPS	Hollenberg MD	Oikonomopoulou K et al.:Proteinase-activated receptors,... (S01.029)	16885167,
KLK6_HUMAN	49	RGYP.\|.PGQV	inferred from experiment	unknown	MEROPS	Hollenberg MD	Oikonomopoulou K et al.:Proteinase-activated receptors,... (S01.029)	16885167,
KLK5_HUMAN	51	YPGQ.\|.QVCA	inferred from experiment	unknown	MEROPS	Hollenberg MD	Oikonomopoulou K et al.:Proteinase-activated receptors,... (S01.029)	16885167,

TopFIND

Q96RI0: Proteinase-activated receptor 4

General Information

9

N-termini

9

C-termini

17

Cleavages

0

Substrates

Sequence

Isoforms

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Protein Neighborhood

Domains & Features

9 N-termini - 9 C-termini - 17 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates