P55085: Proteinase-activated receptor 2

General Information

Protein names	- Proteinase-activated receptor 2 - PAR-2 - Coagulation factor II receptor-like 1 - G-protein coupled receptor 11 - Thrombin receptor-like 1 - Proteinase-activated receptor 2, alternate cleaved 1 - Proteinase-activated receptor 2, alternate cleaved 2
Gene names	F2RL1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P55085

25 N-termini

24 C-termini

42 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MRSPSAAWLL GAAILLAASL SCSGTIQGTN RSSKGRSLIG KVDGTSHVTG KGVTVETVFS
        70         80         90        100        110        120
VDEFSASVLT GKLTTVFLPI VYTIVFVVGL PSNGMALWVF LFRTKKKHPA VIYMANLALA
       130        140        150        160        170        180
DLLSVIWFPL KIAYHIHGNN WIYGEALCNV LIGFFYGNMY CSILFMTCLS VQRYWVIVNP
       190        200        210        220        230        240
MGHSRKKANI AIGISLAIWL LILLVTIPLY VVKQTIFIPA LNITTCHDVL PEQLLVGDMF
       250        260        270        280        290        300
NYFLSLAIGV FLFPAFLTAS AYVLMIRMLR SSAMDENSEK KRKRAIKLIV TVLAMYLICF
       310        320        330        340        350        360
TPSNLLLVVH YFLIKSQGQS HVYALYIVAL CLSTLNSCID PFVYYFVSHD FRDHAKNALL
       370        380        390
CRSVRTVKQM QVSLTSKKHS RKSSSYSSSS TTVKTSY

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

25 N-termini - 24 C-termini - 42 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P55085-26-unknown	IQGTNR...	26	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P55085-32-unknown	SSKGRS...	32	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16471
P55085-32-unknown	SSKGRS...	32	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15994
P55085-35-unknown	GRSLIG...	35	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27793
P55085-35-unknown	GRSLIG...	35	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27592
P55085-37-unknown	SLIGKV...	37	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P55085-37-unknown	SLIGKV...	37	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31790
P55085-37-unknown	SLIGKV...	37	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15995
P55085-37-unknown	SLIGKV...	37	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31615
P55085-37-unknown	SLIGKV...	37	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27794
P55085-37-unknown	SLIGKV...	37	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31914
P55085-37-unknown	SLIGKV...	37	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27593
P55085-37-unknown	SLIGKV...	37	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31963
P55085-37-unknown	SLIGKV...	37	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16353
P55085-37-unknown	SLIGKV...	37	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31975
P55085-37-unknown	SLIGKV...	37	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16623
P55085-38-unknown	LIGKVD...	38	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P55085-39-unknown	IGKVDG...	39	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P55085-39-unknown	IGKVDG...	39	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4891
P55085-42-unknown	VDGTSH...	42	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15996
P55085-42-unknown	VDGTSH...	42	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27795
P55085-42-unknown	VDGTSH...	42	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31976
P55085-42-unknown	VDGTSH...	42	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16624
P55085-43-unknown	DGTSHV...	43	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9463
P55085-46-unknown	SHVTGK...	46	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1049
P55085-49-unknown	TGKGVT...	49	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27796
P55085-49-unknown	TGKGVT...	49	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9464
P55085-52-unknown	GVTVET...	52	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15997
P55085-52-unknown	GVTVET...	52	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16625
P55085-54-unknown	TVETVF...	54	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9465
P55085-56-unknown	ETVFSV...	56	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27797
P55085-58-unknown	VFSVDE...	58	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27798
P55085-59-unknown	FSVDEF...	59	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1050
P55085-59-unknown	FSVDEF...	59	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9466
P55085-60-unknown	SVDEFS...	60	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC773
P55085-60-unknown	SVDEFS...	60	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4892
P55085-62-unknown	DEFSAS...	62	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27799
P55085-63-unknown	EFSASV...	63	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27800
P55085-65-unknown	SASVLT...	65	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4893
P55085-72-unknown	KLTTVF...	72	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1051
P55085-73-unknown	LTTVFL...	73	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27801
P55085-75-unknown	TVFLPI...	75	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27802
P55085-75-unknown	TVFLPI...	75	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9467
P55085-76-unknown	VFLPIV...	76	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27803
P55085-76-unknown	VFLPIV...	76	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P55085-77-unknown	FLPIVY...	77	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27804
P55085-77-unknown	FLPIVY...	77	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9468
P55085-95-unknown	MALWVF...	95	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000425622

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...QGTNRS	31	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16471
...QGTNRS	31	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15994
...NRSSKG	34	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27793
...NRSSKG	34	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27592
...SSKGRS	36	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31790
...SSKGRS	36	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15995
...SSKGRS	36	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31615
...SSKGRS	36	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27794
...SSKGRS	36	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31914
...SSKGRS	36	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27593
...SSKGRS	36	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31963
...SSKGRS	36	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16353
...SSKGRS	36	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31975
...SSKGRS	36	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16623
...KGRSLI	38	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4891
...SLIGKV	41	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15996
...SLIGKV	41	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27795
...SLIGKV	41	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31976
...SLIGKV	41	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16624
...LIGKVD	42	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9463
...KVDGTS	45	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1049
...GTSHVT	48	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27796
...GTSHVT	48	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9464
...HVTGKG	51	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15997
...HVTGKG	51	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16625
...TGKGVT	53	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9465
...KGVTVE	55	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27797
...VTVETV	57	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27798
...TVETVF	58	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1050
...TVETVF	58	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9466
...VETVFS	59	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC773
...VETVFS	59	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4892
...TVFSVD	61	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27799
...VFSVDE	62	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27800
...SVDEFS	64	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4893
...SVLTGK	71	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1051
...VLTGKL	72	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27801
...TGKLTT	74	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27802
...TGKLTT	74	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9467
...GKLTTV	75	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27803
...KLTTVF	76	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27804
...KLTTVF	76	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9468
...ILLVTI	206	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000425622
...VKTSY	397	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
KLK5_HUMAN	31	TNRS.\|.SSKG	inferred from experiment	unknown	MEROPS	Hollenberg MD	Oikonomopoulou K et al.:Proteinase-activated receptors,... (S01.029)	16885167,
KLK14_HUMAN	31	TNRS.\|.SSKG	inferred from experiment	unknown	MEROPS	Hollenberg MD	Oikonomopoulou K et al.:Proteinase-activated receptors,... (S01.029)	16885167,
PRTN3_HUMAN	34	SSKG.\|.GRSL	inferred from experiment	unknown	MEROPS		Merops PRTN3_HUMAN -> PAR2_HUMAN @34
PLMN_HUMAN	34	SSKG.\|.GRSL	inferred from experiment	unknown	MEROPS	Lanza F	Loew D et al.:Proteolysis of the exodomain of... (S01.133)	10978167,
THRB_HUMAN	36	KGRS.\|.SLIG	inferred from experiment	unknown	MEROPS	Lanza F	Loew D et al.:Proteolysis of the exodomain of... (S01.133)	10978167,
KLK14_HUMAN	36	KGRS.\|.SLIG	inferred from experiment	unknown	MEROPS	Hollenberg MD	Oikonomopoulou K et al.:Proteinase-activated receptors,... (S01.029)	16885167,
ST14_HUMAN	36	KGRS.\|.SLIG	inferred from experiment	unknown	MEROPS	Uhland K	Uhland K et al.:Matriptase and its putative rol... (S01.302)	17131055,
PRTN3_HUMAN	36	KGRS.\|.SLIG	inferred from experiment	unknown	MEROPS		Merops PRTN3_HUMAN -> PAR2_HUMAN @36
TRY1_HUMAN	36	KGRS.\|.SLIG	inferred from experiment	unknown	MEROPS	Bunnett NW	Bohm SK et al.:Molecular cloning, expression a... (S01.127)	8615752,
PLMN_HUMAN	36	KGRS.\|.SLIG	inferred from experiment	unknown	MEROPS	Lanza F	Loew D et al.:Proteolysis of the exodomain of... (S01.133)	10978167,
TRY3_HUMAN	36	KGRS.\|.SLIG	inferred from experiment	unknown	MEROPS	Bunnett NW	Knecht W et al.:Trypsin IV or mesotrypsin and p... (S01.174)	17623652,
KLK4_HUMAN	36	KGRS.\|.SLIG	inferred from experiment	unknown	MEROPS	Nelson PS	Matsumura M et al.:Substrates of the prostate-spec... (S01.251)	15389820,
TRYB1_HUMAN	36	KGRS.\|.SLIG	inferred from experiment	unknown	MEROPS	Brass LF	Molino M et al.:Interactions of mast cell trypt... (S01.143)	9020112,
KLK6_HUMAN	36	KGRS.\|.SLIG	inferred from experiment	unknown	MEROPS	Hollenberg MD	Oikonomopoulou K et al.:Proteinase-activated receptors,... (S01.029)	16885167,
CATG_HUMAN	38	RSLI.\|.IGKV	inferred from experiment	unknown	MEROPS	Lanza F	Loew D et al.:Proteolysis of the exodomain of... (S01.133)	10978167,
KLK14_HUMAN	41	IGKV.\|.VDGT	inferred from experiment	unknown	MEROPS	Hollenberg MD	Oikonomopoulou K et al.:Proteinase-activated receptors,... (S01.029)	16885167,
PRTN3_HUMAN	41	IGKV.\|.VDGT	inferred from experiment	unknown	MEROPS		Merops PRTN3_HUMAN -> PAR2_HUMAN @41
TRYB1_HUMAN	41	IGKV.\|.VDGT	inferred from experiment	unknown	MEROPS	Brass LF	Molino M et al.:Interactions of mast cell trypt... (S01.143)	9020112,
KLK6_HUMAN	41	IGKV.\|.VDGT	inferred from experiment	unknown	MEROPS	Hollenberg MD	Oikonomopoulou K et al.:Proteinase-activated receptors,... (S01.029)	16885167,
ELNE_HUMAN	42	GKVD.\|.DGTS	inferred from experiment	unknown	MEROPS	Lanza F	Loew D et al.:Proteolysis of the exodomain of... (S01.133)	10978167,
CAN2_HUMAN	45	DGTS.\|.SHVT	inferred from experiment	unknown	MEROPS	Lanza F	Loew D et al.:Proteolysis of the exodomain of... (C02.001)	10978167,
PRTN3_HUMAN	48	SHVT.\|.TGKG	inferred from experiment	unknown	MEROPS	Lanza F	Loew D et al.:Proteolysis of the exodomain of... (S01.133)	10978167,
ELNE_HUMAN	48	SHVT.\|.TGKG	inferred from experiment	unknown	MEROPS	Lanza F	Loew D et al.:Proteolysis of the exodomain of... (S01.133)	10978167,
KLK14_HUMAN	51	TGKG.\|.GVTV	inferred from experiment	unknown	MEROPS	Hollenberg MD	Oikonomopoulou K et al.:Proteinase-activated receptors,... (S01.029)	16885167,
KLK6_HUMAN	51	TGKG.\|.GVTV	inferred from experiment	unknown	MEROPS	Hollenberg MD	Oikonomopoulou K et al.:Proteinase-activated receptors,... (S01.029)	16885167,
ELNE_HUMAN	53	KGVT.\|.TVET	inferred from experiment	unknown	MEROPS	Lanza F	Loew D et al.:Proteolysis of the exodomain of... (S01.133)	10978167,
PRTN3_HUMAN	55	VTVE.\|.ETVF	inferred from experiment	unknown	MEROPS	Lanza F	Loew D et al.:Proteolysis of the exodomain of... (S01.133)	10978167,
PRTN3_HUMAN	57	VETV.\|.VFSV	inferred from experiment	unknown	MEROPS	Lanza F	Loew D et al.:Proteolysis of the exodomain of... (S01.133)	10978167,
CAN2_HUMAN	58	ETVF.\|.FSVD	inferred from experiment	unknown	MEROPS	Lanza F	Loew D et al.:Proteolysis of the exodomain of... (C02.001)	10978167,
ELNE_HUMAN	58	ETVF.\|.FSVD	inferred from experiment	unknown	MEROPS	Lanza F	Loew D et al.:Proteolysis of the exodomain of... (S01.133)	10978167,
CAN1_HUMAN	59	TVFS.\|.SVDE	inferred from experiment	unknown	MEROPS	Lanza F	Loew D et al.:Proteolysis of the exodomain of... (C02.001)	10978167,
CATG_HUMAN	59	TVFS.\|.SVDE	inferred from experiment	unknown	MEROPS	Lanza F	Loew D et al.:Proteolysis of the exodomain of... (S01.133)	10978167,
PRTN3_HUMAN	61	FSVD.\|.DEFS	inferred from experiment	unknown	MEROPS	Lanza F	Loew D et al.:Proteolysis of the exodomain of... (S01.133)	10978167,
PRTN3_HUMAN	62	SVDE.\|.EFSA	inferred from experiment	unknown	MEROPS	Lanza F	Loew D et al.:Proteolysis of the exodomain of... (S01.133)	10978167,
CATG_HUMAN	64	DEFS.\|.SASV	inferred from experiment	unknown	MEROPS	Lanza F	Loew D et al.:Proteolysis of the exodomain of... (S01.133)	10978167,
CAN2_HUMAN	71	LTGK.\|.KLTT	inferred from experiment	unknown	MEROPS	Lanza F	Loew D et al.:Proteolysis of the exodomain of... (C02.001)	10978167,
PRTN3_HUMAN	72	TGKL.\|.LTTV	inferred from experiment	unknown	MEROPS	Lanza F	Loew D et al.:Proteolysis of the exodomain of... (S01.133)	10978167,
PRTN3_HUMAN	74	KLTT.\|.TVFL	inferred from experiment	unknown	MEROPS	Lanza F	Loew D et al.:Proteolysis of the exodomain of... (S01.133)	10978167,
ELNE_HUMAN	74	KLTT.\|.TVFL	inferred from experiment	unknown	MEROPS	Lanza F	Loew D et al.:Proteolysis of the exodomain of... (S01.133)	10978167,
PRTN3_HUMAN	75	LTTV.\|.VFLP	inferred from experiment	unknown	MEROPS	Lanza F	Loew D et al.:Proteolysis of the exodomain of... (S01.133)	10978167,
PRTN3_HUMAN	76	TTVF.\|.FLPI	inferred from experiment	unknown	MEROPS	Lanza F	Loew D et al.:Proteolysis of the exodomain of... (S01.133)	10978167,
ELNE_HUMAN	76	TTVF.\|.FLPI	inferred from experiment	unknown	MEROPS	Lanza F	Loew D et al.:Proteolysis of the exodomain of... (S01.133)	10978167,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)