TopFIND 4.0

P07477: Trypsin-1

General Information

Protein names	- Trypsin-1 - 3.4.21.4 - Beta-trypsin - Cationic trypsinogen - Serine protease 1 - Trypsin I - Alpha-trypsin chain 1 - Alpha-trypsin chain 2
Gene names	PRSS1
Organism	Homo sapiens
Protease Family	S01.127
Protease ID	S01.127
Chromosome location
UniProt ID	P07477

9 N-termini

9 C-termini

9 Cleavages

5 Substrates

Sequence

        10         20         30         40         50         60
MNPLLILTFV AAALAAPFDD DDKIVGGYNC EENSVPYQVS LNSGYHFCGG SLINEQWVVS
        70         80         90        100        110        120
AGHCYKSRIQ VRLGEHNIEV LEGNEQFINA AKIIRHPQYD RKTLNNDIML IKLSSRAVIN
       130        140        150        160        170        180
ARVSTISLPT APPATGTKCL ISGWGNTASS GADYPDELQC LDAPVLSQAK CEASYPGKIT
       190        200        210        220        230        240
SNMFCVGFLE GGKDSCQGDS GGPVVCNGQL QGVVSWGDGC AQKNKPGVYT KVYNYVKWIK

NTIAANS

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

9 N-termini - 9 C-termini - 9 Cleavages - 5 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P07477-19-unknown	DDDDKI...	19	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8453
P07477-24-unknown	IVGGYN...	24	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P07477-42-unknown	NSGYHF...	42	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8454
P07477-51-unknown	SLINEQ...	51	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000419912
P07477-51-unknown	SLINEQ...	51	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000455868
P07477-82-unknown	EGNEQF...	82	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8455
P07477-104-unknown	LNNDIM...	104	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7218
P07477-123-unknown	VSTISL...	123	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P07477-123-unknown	VSTISL...	123	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31912
P07477-123-unknown	VSTISL...	123	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31961
P07477-190-unknown	EGGKDS...	190	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7219
P07477-190-unknown	EGGKDS...	190	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5440
P07477-191-unknown	GGKDSC...	191	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5441

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LAAPFD	18	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8453
...YQVSLN	41	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8454
...NIEVLE	81	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8455
...YDRKTL	103	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7218
...VINARV	122	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...VINARV	122	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31912
...VINARV	122	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31961
...CVGFLE	189	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7219
...CVGFLE	189	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5440
...VGFLEG	190	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5441
...FLEGGK	192	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000419912
...FLEGGK	192	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000455868
...IAANS	247	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CTRC_HUMAN	18	APFD.\|.DDDD	inferred from experiment	unknown	MEROPS	Sahin-Toth M	Nemoda Z et al.:Chymotrypsin C (caldecrin) stim... (S01.157)	16505482,
CTRC_HUMAN	41	VSLN.\|.NSGY	inferred from experiment	unknown	MEROPS	Sahin-Toth M	Szmola R et al.:Chymotrypsin C (caldecrin) prom... (S01.157)	17592142,
CTRC_HUMAN	81	EVLE.\|.EGNE	inferred from experiment	unknown	MEROPS	Sahin-Toth M	Szmola R et al.:Chymotrypsin C (caldecrin) prom... (S01.157)	17592142,
CATS_HUMAN	103	RKTL.\|.LNND	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
TRY1_HUMAN	122	NARV.\|.VSTI	inferred from experiment	unknown	MEROPS	Sahin-Toth M	Szmola R et al.:Chymotrypsin C (caldecrin) prom... (S01.157)	17592142,
TRY3_HUMAN	122	NARV.\|.VSTI	inferred from experiment	unknown	MEROPS	Sahin-Toth M	Szmola R et al.:Human mesotrypsin is a unique d... (S01.174)	14507909,
CATS_HUMAN	189	GFLE.\|.EGGK	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	189	GFLE.\|.EGGK	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	190	FLEG.\|.GGKD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
PAR2_HUMAN	36	KGRS.\|.SLIG	inferred from experiment	unknown	MEROPS	Bunnett NW	Bohm SK et al.:Molecular cloning, expression a... (S01.127)	8615752,
ISK1_HUMAN	41	CTKI.\|.IYDP	inferred from experiment	unknown	MEROPS	Becker M	Witt H et al.:Mutations in the gene encoding ... (S01.127)	10835640,
MEP1A_HUMAN	65	KSRN.\|.NGLR	inferred from experiment	unknown	MEROPS	Sterchi EE	Rosmann S et al.:Activation of human meprin-alph... (S01.233)	12189145,
CBPB1_HUMAN	110	RVRA.\|.ATGH	inferred from experiment	unknown	MEROPS	French CK	Yamamoto KK et al.:Isolation of a cDNA encoding a ... (S01.127)	1370825,
TRY1_HUMAN	122	NARV.\|.VSTI	inferred from experiment	unknown	MEROPS	Sahin-Toth M	Szmola R et al.:Chymotrypsin C (caldecrin) prom... (S01.157)	17592142,