P15086: Carboxypeptidase B

General Information

Protein names	- Carboxypeptidase B - 3.4.17.2 {ECO:0000250\|UniProtKB:P00732} - Pancreas-specific protein - PASP
Gene names	CPB1
Organism	Homo sapiens
Protease Family
Protease ID	M14.003
Chromosome location
UniProt ID	P15086

1 N-termini

5 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MLALLVLVTV ALASAHHGGE HFEGEKVFRV NVEDENHINI IRELASTTQI DFWKPDSVTQ
        70         80         90        100        110        120
IKPHSTVDFR VKAEDTVTVE NVLKQNELQY KVLISNLRNV VEAQFDSRVR ATGHSYEKYN
       130        140        150        160        170        180
KWETIEAWTQ QVATENPALI SRSVIGTTFE GRAIYLLKVG KAGQNKPAIF MDCGFHAREW
       190        200        210        220        230        240
ISPAFCQWFV REAVRTYGRE IQVTELLDKL DFYVLPVLNI DGYIYTWTKS RFWRKTRSTH
       250        260        270        280        290        300
TGSSCIGTDP NRNFDAGWCE IGASRNPCDE TYCGPAAESE KETKALADFI RNKLSSIKAY
       310        320        330        340        350        360
LTIHSYSQMM IYPYSYAYKL GENNAELNAL AKATVKELAS LHGTKYTYGP GATTIYPAAG
       370        380        390        400        410
GSDDWAYDQG IRYSFTFELR DTGRYGFLLP ESQIRATCEE TFLAIKYVAS YVLEHLY

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

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Biological System:

Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

1 N-termini - 5 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P15086-111-unknown	ATGHSY...	111	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P15086-111-unknown	ATGHSY...	111	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31913
P15086-111-unknown	ATGHSY...	111	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16305

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PDSVTQ	59	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000419114
...SNLRNV	99	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000417117
...DSRVRA	110	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31913
...DSRVRA	110	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16305
...WRKTRS	237	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000419427
...LEHLY	417	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
TRY1_HUMAN	110	RVRA.\|.ATGH	inferred from experiment	unknown	MEROPS	French CK	Yamamoto KK et al.:Isolation of a cDNA encoding a ... (S01.127)	1370825,
KLK4_HUMAN	110	RVRA.\|.ATGH	inferred from experiment	unknown	MEROPS	Nelson PS	Matsumura M et al.:Substrates of the prostate-spec... (S01.251)	15389820,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)