Q99895: Chymotrypsin-C

General Information

Protein names	- Chymotrypsin-C - 3.4.21.2 - Caldecrin
Gene names	CTRC
Organism	Homo sapiens
Protease Family	S01.157
Protease ID	S01.157
Chromosome location
UniProt ID	Q99895

2 N-termini

2 C-termini

1 Cleavages

6 Substrates

Sequence

        10         20         30         40         50         60
MLGITVLAAL LACASSCGVP SFPPNLSARV VGGEDARPHS WPWQISLQYL KNDTWRHTCG
        70         80         90        100        110        120
GTLIASNFVL TAAHCISNTR TYRVAVGKNN LEVEDEEGSL FVGVDTIHVH KRWNALLLRN
       130        140        150        160        170        180
DIALIKLAEH VELSDTIQVA CLPEKDSLLP KDYPCYVTGW GRLWTNGPIA DKLQQGLQPV
       190        200        210        220        230        240
VDHATCSRID WWGFRVKKTM VCAGGDGVIS ACNGDSGGPL NCQLENGSWE VFGIVSFGSR
       250        260
RGCNTRKKPV VYTRVSAYID WINEKMQL

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 1 Cleavages - 6 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q99895-17-unknown	CGVPSF...	17	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q99895-30-unknown	VVGGED...	30	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q99895-30-unknown	VVGGED...	30	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16384

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...NLSARV	29	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16384
	...EKMQL	268	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
KLK4_HUMAN	29	SARV.\|.VVGG	inferred from experiment	unknown	MEROPS	Nelson PS	Matsumura M et al.:Substrates of the prostate-spec... (S01.251)	15389820,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
TRY1_HUMAN	18	APFD.\|.DDDD	inferred from experiment	unknown	MEROPS	Sahin-Toth M	Nemoda Z et al.:Chymotrypsin C (caldecrin) stim... (S01.157)	16505482,
TRY2_HUMAN	18	APFD.\|.DDDD	inferred from experiment	unknown	MEROPS	Sahin-Toth M	Nemoda Z et al.:Chymotrypsin C (caldecrin) stim... (S01.157)	16505482,
NEU1_HUMAN	23	YIQN.\|.NCPL	inferred from experiment	unknown	MEROPS	COLE PW	FOLK JE et al.:CHYMOTRYPSIN C. II. ENZYMATIC S... (S01.157)	14253411,
NEU1_HUMAN	27	CPLG.\|.GGKR	inferred from experiment	unknown	MEROPS	COLE PW	FOLK JE et al.:CHYMOTRYPSIN C. II. ENZYMATIC S... (S01.157)	14253411,
TRY1_HUMAN	41	VSLN.\|.NSGY	inferred from experiment	unknown	MEROPS	Sahin-Toth M	Szmola R et al.:Chymotrypsin C (caldecrin) prom... (S01.157)	17592142,
TRY1_HUMAN	81	EVLE.\|.EGNE	inferred from experiment	unknown	MEROPS	Sahin-Toth M	Szmola R et al.:Chymotrypsin C (caldecrin) prom... (S01.157)	17592142,