P07478: Trypsin-2
| Protein names | - Trypsin-2 - 3.4.21.4 - Anionic trypsinogen - Serine protease 2 - Trypsin II |
|---|---|
| Gene names | PRSS2 |
| Organism | Homo sapiens |
| Protease Family | S01.258 |
| Protease ID | S01.258 |
| Chromosome location | |
| UniProt ID | P07478 |
2
N-termini
4
C-termini
2
Cleavages
12
Substrates
Sequence
10 20 30 40 50 60
MNLLLILTFV AAAVAAPFDD DDKIVGGYIC EENSVPYQVS LNSGYHFCGG SLISEQWVVS
70 80 90 100 110 120
AGHCYKSRIQ VRLGEHNIEV LEGNEQFINA AKIIRHPKYN SRTLDNDILL IKLSSPAVIN
130 140 150 160 170 180
SRVSAISLPT APPAAGTESL ISGWGNTLSS GADYPDELQC LDAPVLSQAE CEASYPGKIT
190 200 210 220 230 240
NNMFCVGFLE GGKDSCQGDS GGPVVSNGEL QGIVSWGYGC AQKNRPGVYT KVYNYVDWIK
DTIAANS
Isoforms
Sequence View
Protein Neighborhood
Domains & Features
2 N-termini - 4 C-termini - 2 Cleavages - 12 Substrates
N-termini
| Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
|---|---|---|---|---|---|---|---|---|---|
| P07478-19-unknown | DDDDKI... | 19 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC8456 | |||
| P07478-24-unknown | IVGGYI... | 24 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| P07478-24-unknown | IVGGYI... | 24 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC3515 |
C-termini
| Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| ...VAAPFD | 18 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC8456 | |||
| ...DDDDKI | 23 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC3515 | |||
| ...AECEAS | 173 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000458158 | |||
| ...IAANS | 247 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
| Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| CTRC_HUMAN | 18 | APFD.|.DDDD | inferred from experiment | unknown | MEROPS | Sahin-Toth M | Nemoda Z et al.:Chymotrypsin C (caldecrin) stim... (S01.157) | 16505482, |
| CATB_HUMAN | 23 | DDKI.|.IVGG | inferred from experiment | unknown | MEROPS | Keim V | Teich N et al.:Cathepsin B cleavage of the try... (C01.060) | 12102727, |
Substrates
| Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| MMP2-Isoform2_HUMAN | 22 | TMRK.|.KPRC | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC31922 | ||
| MMP2-Isoform3_HUMAN | 48 | TMRK.|.KPRC | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC31922 | ||
| DEF5_HUMAN | 62 | QARA.|.ATCY | inferred from experiment | unknown | MEROPS | Ouellette AJ | Weeks CS et al.:Matrix metalloproteinase-7 acti... (S01.258) | 16822871, |
| DEF5_HUMAN | 68 | YCRT.|.TGRC | inferred from experiment | unknown | MEROPS | Ouellette AJ | Weeks CS et al.:Matrix metalloproteinase-7 acti... (S01.258) | 16822871, |
| MMP2_HUMAN | 98 | TMRK.|.KPRC | inferred from experiment | unknown | MEROPS | Stenman UH | Sorsa T et al.:Activation of type IV procollag... (S01.258) | 9261109, |
| MMP9_HUMAN | 106 | LGRF.|.FQTF | inferred from experiment | unknown | MEROPS | Stenman UH | Sorsa T et al.:Activation of type IV procollag... (S01.258) | 9261109, |
| CO2A1-Isoform1_HUMAN | 749 | GARG.|.GAPG | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC31916 | ||
| CO2A1_HUMAN | 818 | GARG.|.GAPG | inferred from experiment | unknown | MEROPS | Konttinen YT | Stenman M et al.:Trypsin-2 degrades human type I... (S01.258) | 16192646, |
| CO2A1-Isoform1_HUMAN | 835 | AGRV.|.VGPP | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC31918 | ||
| CO2A1_HUMAN | 904 | AGRV.|.VGPP | inferred from experiment | unknown | MEROPS | Konttinen YT | Stenman M et al.:Trypsin-2 degrades human type I... (S01.258) | 16192646, |
| CO2A1-Isoform1_HUMAN | 1121 | GPRG.|.GRSG | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC31920 | ||
| CO2A1_HUMAN | 1190 | GPRG.|.GRSG | inferred from experiment | unknown | MEROPS | Konttinen YT | Stenman M et al.:Trypsin-2 degrades human type I... (S01.258) | 16192646, |