P00995: Serine protease inhibitor Kazal-type 1 {ECO:0000312|HGNC:HGNC:11244}
| Protein names | - Serine protease inhibitor Kazal-type 1 {ECO:0000312|HGNC:HGNC:11244} - Pancreatic secretory trypsin inhibitor {ECO:0000303|PubMed:3501289} - Tumor-associated trypsin inhibitor - TATI |
|---|---|
| Gene names | SPINK1 |
| Organism | Homo sapiens |
| Protease Family | |
| Protease ID | I01.011 |
| Chromosome location | |
| UniProt ID | P00995 |
4
N-termini
6
C-termini
5
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MKVTGIFLLS ALALLSLSGN TGADSLGREA KCYNELNGCT KIYDPVCGTD GNTYPNECVL
70
CFENRKRQTS ILIQKSGPC
Isoforms
Sequence View
Protein Neighborhood
Domains & Features
4 N-termini - 6 C-termini - 5 Cleavages - 0 Substrates
N-termini
| Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
|---|---|---|---|---|---|---|---|---|---|
| P00995-24-unknown | DSLGRE... | 24 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| P00995-29-unknown | EAKCYN... | 29 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC31928 | |||
| P00995-42-unknown | IYDPVC... | 42 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC31911 | |||
| P00995-42-unknown | IYDPVC... | 42 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC31929 | |||
| P00995-68-unknown | QTSILI... | 68 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC31930 |
C-termini
| Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| ...DSLGRE | 28 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC31928 | |||
| ...NGCTKI | 41 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC31911 | |||
| ...NGCTKI | 41 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC31929 | |||
| ...CFENRK | 65 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000427376 | |||
| ...ENRKRQ | 67 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC31930 | |||
| ...ILIQKS | 75 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC31931 | |||
| ...KSGPC | 79 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
| Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| TRY3_HUMAN | 28 | LGRE.|.EAKC | inferred from experiment | unknown | MEROPS | Sahin-Toth M | Szmola R et al.:Human mesotrypsin is a unique d... (S01.174) | 14507909, |
| TRY1_HUMAN | 41 | CTKI.|.IYDP | inferred from experiment | unknown | MEROPS | Becker M | Witt H et al.:Mutations in the gene encoding ... (S01.127) | 10835640, |
| TRY3_HUMAN | 41 | CTKI.|.IYDP | inferred from experiment | unknown | MEROPS | Sahin-Toth M | Szmola R et al.:Human mesotrypsin is a unique d... (S01.174) | 14507909, |
| TRY3_HUMAN | 67 | RKRQ.|.QTSI | inferred from experiment | unknown | MEROPS | Sahin-Toth M | Szmola R et al.:Human mesotrypsin is a unique d... (S01.174) | 14507909, |
| TRY3_HUMAN | 75 | IQKS.|.SGPC | inferred from experiment | unknown | MEROPS | Sahin-Toth M | Szmola R et al.:Human mesotrypsin is a unique d... (S01.174) | 14507909, |
Substrates
| Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|