TopFIND 4.0

P07384: Calpain-1 catalytic subunit {ECO:0000305}

General Information

Protein names
- Calpain-1 catalytic subunit {ECO:0000305}
- 3.4.22.52 {ECO:0000269|PubMed:21531719}
- Calcium-activated neutral proteinase 1 {ECO:0000303|PubMed:3017764}
- CANP 1 {ECO:0000303|PubMed:3017764}
- Calpain mu-type {ECO:0000303|PubMed:2400579}
- Calpain-1 large subunit {ECO:0000303|PubMed:3017764}
- Cell proliferation-inducing gene 30 protein {ECO:0000303|Ref.3}
- Micromolar-calpain {ECO:0000303|PubMed:3017764}
- muCANP {ECO:0000303|PubMed:3017764}
Gene names CAPN1
Organism Homo sapiens
Protease Family C02.001
Protease ID C02.001
Chromosome location
UniProt ID P07384

7

N-termini

12

C-termini

2

Cleavages

139

Substrates

Sequence

        10         20         30         40         50         60 
MSEEIITPVY CTGVSAQVQK QRARELGLGR HENAIKYLGQ DYEQLRVRCL QSGTLFRDEA 
        70         80         90        100        110        120 
FPPVPQSLGY KDLGPNSSKT YGIKWKRPTE LLSNPQFIVD GATRTDICQG ALGDCWLLAA 
       130        140        150        160        170        180 
IASLTLNDTL LHRVVPHGQS FQNGYAGIFH FQLWQFGEWV DVVVDDLLPI KDGKLVFVHS 
       190        200        210        220        230        240 
AEGNEFWSAL LEKAYAKVNG SYEALSGGST SEGFEDFTGG VTEWYELRKA PSDLYQIILK 
       250        260        270        280        290        300 
ALERGSLLGC SIDISSVLDM EAITFKKLVK GHAYSVTGAK QVNYRGQVVS LIRMRNPWGE 
       310        320        330        340        350        360 
VEWTGAWSDS SSEWNNVDPY ERDQLRVKME DGEFWMSFRD FMREFTRLEI CNLTPDALKS 
       370        380        390        400        410        420 
RTIRKWNTTL YEGTWRRGST AGGCRNYPAT FWVNPQFKIR LDETDDPDDY GDRESGCSFV 
       430        440        450        460        470        480 
LALMQKHRRR ERRFGRDMET IGFAVYEVPP ELVGQPAVHL KRDFFLANAS RARSEQFINL 
       490        500        510        520        530        540 
REVSTRFRLP PGEYVVVPST FEPNKEGDFV LRFFSEKSAG TVELDDQIQA NLPDEQVLSE 
       550        560        570        580        590        600 
EEIDENFKAL FRQLAGEDME ISVKELRTIL NRIISKHKDL RTKGFSLESC RSMVNLMDRD 
       610        620        630        640        650        660 
GNGKLGLVEF NILWNRIRNY LSIFRKFDLD KSGSMSAYEM RMAIESAGFK LNKKLYELII 
       670        680        690        700        710    
TRYSEPDLAV DFDNFVCCLV RLETMFRFFK TLDTDLDGVV TFDLFKWLQL TMFA

Isoforms



Sequence View



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Protein Neighborhood

Domains & Features

7 N-termini - 12 C-termini - 2 Cleavages - 139 Substrates

N-termini

C-termini

Cleavages

Substrates