Q16566: Calcium/calmodulin-dependent protein kinase type IV

General Information

Protein names	- Calcium/calmodulin-dependent protein kinase type IV - CaMK IV - 2.7.11.17 - CaM kinase-GR
Gene names	CAMK4
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q16566

4 N-termini

4 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MLKVTVPSCS ASSCSSVTAS AAPGTASLVP DYWIDGSNRD ALSDFFEVES ELGRGATSIV
        70         80         90        100        110        120
YRCKQKGTQK PYALKVLKKT VDKKIVRTEI GVLLRLSHPN IIKLKEIFET PTEISLVLEL
       130        140        150        160        170        180
VTGGELFDRI VEKGYYSERD AADAVKQILE AVAYLHENGI VHRDLKPENL LYATPAPDAP
       190        200        210        220        230        240
LKIADFGLSK IVEHQVLMKT VCGTPGYCAP EILRGCAYGP EVDMWSVGII TYILLCGFEP
       250        260        270        280        290        300
FYDERGDQFM FRRILNCEYY FISPWWDEVS LNAKDLVRKL IVLDPKKRLT TFQALQHPWV
       310        320        330        340        350        360
TGKAANFVHM DTAQKKLQEF NARRKLKAAV KAVVASSRLG SASSSHGSIQ ESHKASRDPS
       370        380        390        400        410        420
PIQDGNEDMK AIPEGEKIQG DGAQAAVKGA QAELMKVQAL EKVKGADINA EEAPKMVPKA
       430        440        450        460        470
VEDGIKVADL ELEEGLAEEK LKTVEEAAAP REGQGSSAVG FEVPQQDVIL PEY

Isoforms

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 4 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q16566-1-unknown	MLKVTV...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q16566-27-	SLVPDY...	27		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q16566-36-unknown	GSNRDA...	36	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2244
Q16566-204-unknown	TPGYCA...	204	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC834

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DYWIDG	35	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2244
...ERDAAD	142	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000426940
...KTVCGT	203	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC834
...ILPEY	473	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_HUMAN	35	WIDG.\|.GSNR	inferred from experiment	unknown	MEROPS	Wang KK	McGinnis KM et al.:Calcium/calmodulin-dependent pr... (C02.001)	9685336,
CAN1_HUMAN	203	VCGT.\|.TPGY	inferred from experiment	unknown	MEROPS	Wang KK	McGinnis KM et al.:Calcium/calmodulin-dependent pr... (C02.001)	9685336,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)