P55957: BH3-interacting domain death agonist

General Information

Protein names	- BH3-interacting domain death agonist - p22 BID - BID - BH3-interacting domain death agonist p15 - p15 BID - BH3-interacting domain death agonist p13 - p13 BID - BH3-interacting domain death agonist p11 - p11 BID
Gene names	BID
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P55957

12 N-termini

5 C-termini

7 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of BH3-interacting domain death agonist - Isoform 3 of BH3-interacting domain death agonist - Isoform 4 of BH3-interacting domain death agonist

Sequence View

        10         20         30         40         50         60
MDCEVNNGSS LRDECITNLL VFGFLQSCSD NSFRRELDAL GHELPVLAPQ WEGYDELQTD
        70         80         90        100        110        120
GNRSSHSRLG RIEADSESQE DIIRNIARHL AQVGDSMDRS IPPGLVNGLA LQLRNTSRSE
       130        140        150        160        170        180
EDRNRDLATA LEQLLQAYPR DMEKEKTMLV LALLLAKKVA SHTPSLLRDV FHTTVNFINQ
       190
NLRTYVRSLA RNGMD         10         20         30         40         50         60
MDCEVNNGSS LRDECITNLL VFGFLQSCSD NSFRRELDAL GHELPVLAPQ WEGYDELQTD
        70         80         90        100        110        120
GNRSSHSRLG RIEADSESQE DIIRNIARHL AQVGDSMDRS IPPGLVNGLA LQLRNTSRSE
       130        140        150        160        170        180
EDRNRDLATA LEQLLQAYPR DMEKEKTMLV LALLLAKKVA SHTPSLLRDV FHTTVNFINQ
       190
NLRTYVRSLA RNGMD         10         20         30         40         50         60
MDCEVNNGSS LRDECITNLL VFGFLQSCSD NSFRRELDAL GHELPVLAPQ WEGYDELQTD
        70         80         90        100        110        120
GNRSSHSRLG RIEADSESQE DIIRNIARHL AQVGDSMDRS IPPGLVNGLA LQLRNTSRSE
       130        140        150        160        170        180
EDRNRDLATA LEQLLQAYPR DMEKEKTMLV LALLLAKKVA SHTPSLLRDV FHTTVNFINQ
       190
NLRTYVRSLA RNGMD

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

12 N-termini - 5 C-termini - 7 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P55957-1-Acetylation	MDCEVN...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P55957-1-Acetylation	MDCEVN...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P55957-1-Acetylation	MDCEVN...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P55957-1-Acetylation	MDCEVN...	1	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P55957-1-Acetylation	MDCEVN...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt98802
P55957-1-Acetylation	MDCEVN...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt98803
P55957-1-unknown	MDCEVN...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt68462
P55957-1-unknown	MDCEVN...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt102110
P55957-55-unknown	DELQTD...	55		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC794
P55957-55-unknown	DELQTD...	55		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt142434
P55957-61-unknown	GNRSSH...	61		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3097
P55957-61-unknown	GNRSSH...	61		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1932
P55957-61-unknown	GNRSSH...	61		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt142730
P55957-62-unknown	NRSSHS...	62		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P55957-62-unknown	NRSSHS...	62		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt115739
P55957-71-unknown	RIEADS...	71		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC797
P55957-71-unknown	RIEADS...	71		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143309
P55957-76-	SESQED...	76			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P55957-76-unknown	SESQED...	76		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3100
P55957-76-unknown	SESQED...	76		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1935
P55957-76-unknown	SESQED...	76		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11723
P55957-76-unknown	SESQED...	76		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143553
P55957-77-unknown	ESQEDI...	77		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P55957-77-unknown	ESQEDI...	77		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt115795
P55957-82-unknown	IIRNIA...	82		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P55957-82-unknown	IIRNIA...	82		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt196675
P55957-97-unknown	MDRSIP...	97		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt68463
P55957-97-unknown	MDRSIP...	97		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt102177
P55957-100-unknown	SIPPGL...	100		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P55957-100-unknown	SIPPGL...	100		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt115859
P55957-100-unknown	SIPPGL...	100		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt115860

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...QWEGYD	54	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC794
...QWEGYD	54	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122595
...QWEGYD	54	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125628
...ELQTDG	60	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3097
...ELQTDG	60	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1932
...ELQTDG	60	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123077
...ELQTDG	60	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125932
...HSRLGR	70	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC797
...HSRLGR	70	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126539
...HSRLGR	70	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154041
...RIEADS	75	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3100
...RIEADS	75	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1935
...RIEADS	75	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11723
...RIEADS	75	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126793
...RNGMD	195	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...RNGMD	195	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt64081
...RNGMD	195	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt64079

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CAN1_HUMAN	54	EGYD.\|.DELQ	inferred from experiment	unknown	MEROPS	Machleidt W	Gil-Parrado S et al.:Ionomycin-activated calpain tri... (C02.001)	12000759,
CASP8_HUMAN	60	QTDG.\|.GNRS	inferred from experiment	unknown	MEROPS	Dive C	Degli Esposti M et al.:Post-translational modification... (C14.003)	12598529,
CASP3_HUMAN	60	QTDG.\|.GNRS	inferred from experiment	unknown	MEROPS	Dive C	Degli Esposti M et al.:Post-translational modification... (C14.003)	12598529,
CAN1_HUMAN	70	RLGR.\|.RIEA	inferred from experiment	unknown	MEROPS	Shoshan MC	Mandic A et al.:Calpain-mediated Bid cleavage a... (C02.001)	11940658,
CASP8_HUMAN	75	EADS.\|.SESQ	inferred from experiment	unknown	MEROPS	Dive C	Degli Esposti M et al.:Post-translational modification... (C14.003)	12598529,
CASP3_HUMAN	75	EADS.\|.SESQ	inferred from experiment	unknown	MEROPS	Dive C	Degli Esposti M et al.:Post-translational modification... (C14.003)	12598529,
GRAB_HUMAN	75	EADS.\|.SESQ	inferred from experiment	unknown	MEROPS	Rosen A	Casciola-Rosen L et al.:Mouse and human granzyme B have... (S01.010)	17179148,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)