Q01814: Plasma membrane calcium-transporting ATPase 2

General Information

Protein names	- Plasma membrane calcium-transporting ATPase 2 - PMCA2 - 7.2.2.10 - Plasma membrane calcium ATPase isoform 2 - Plasma membrane calcium pump isoform 2
Gene names	ATP2B2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q01814

4 N-termini

4 C-termini

5 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform WA of Plasma membrane calcium-transporting ATPase 2 - Isoform YA of Plasma membrane calcium-transporting ATPase 2 - Isoform ZA of Plasma membrane calcium-transporting ATPase 2 - Isoform YB of Plasma membrane calcium-transporting ATPase 2 - Isoform ZB of Plasma membrane calcium-transporting ATPase 2 - Isoform XA of Plasma membrane calcium-transporting ATPase 2 - Isoform XB of Plasma membrane calcium-transporting ATPase 2

Sequence View

        10         20         30         40         50         60
MGDMTNSDFY SKNQRNESSH GGEFGCTMEE LRSLMELRGT EAVVKIKETY GDTEAICRRL
        70         80         90        100        110        120
KTSPVEGLPG TAPDLEKRKQ IFGQNFIPPK KPKTFLQLVW EALQDVTLII LEIAAIISLG
       130        140        150        160        170        180
LSFYHPPGEG NEGCATAQGG AEDEGEAEAG WIEGAAILLS VICVVLVTAF NDWSKEKQFR
       190        200        210        220        230        240
GLQSRIEQEQ KFTVVRAGQV VQIPVAEIVV GDIAQVKYGD LLPADGLFIQ GNDLKIDESS
       250        260        270        280        290        300
LTGESDQVRK SVDKDPMLLS GTHVMEGSGR MLVTAVGVNS QTGIIFTLLG AGGEEEEKKD
       310        320        330        340        350        360
KKGVKKGDGL QLPAADGAAA SNAADSANAS LVNGKMQDGN VDASQSKAKQ QDGAAAMEMQ
       370        380        390        400        410        420
PLKSAEGGDA DDRKKASMHK KEKSVLQGKL TKLAVQIGKA GLVMSAITVI ILVLYFTVDT
       430        440        450        460        470        480
FVVNKKPWLP ECTPVYVQYF VKFFIIGVTV LVVAVPEGLP LAVTISLAYS VKKMMKDNNL
       490        500        510        520        530        540
VRHLDACETM GNATAICSDK TGTLTTNRMT VVQAYVGDVH YKEIPDPSSI NTKTMELLIN
       550        560        570        580        590        600
AIAINSAYTT KILPPEKEGA LPRQVGNKTE CGLLGFVLDL KQDYEPVRSQ MPEEKLYKVY
       610        620        630        640        650        660
TFNSVRKSMS TVIKLPDESF RMYSKGASEI VLKKCCKILN GAGEPRVFRP RDRDEMVKKV
       670        680        690        700        710        720
IEPMACDGLR TICVAYRDFP SSPEPDWDNE NDILNELTCI CVVGIEDPVR PEVPEAIRKC
       730        740        750        760        770        780
QRAGITVRMV TGDNINTARA IAIKCGIIHP GEDFLCLEGK EFNRRIRNEK GEIEQERIDK
       790        800        810        820        830        840
IWPKLRVLAR SSPTDKHTLV KGIIDSTHTE QRQVVAVTGD GTNDGPALKK ADVGFAMGIA
       850        860        870        880        890        900
GTDVAKEASD IILTDDNFSS IVKAVMWGRN VYDSISKFLQ FQLTVNVVAV IVAFTGACIT
       910        920        930        940        950        960
QDSPLKAVQM LWVNLIMDTF ASLALATEPP TETLLLRKPY GRNKPLISRT MMKNILGHAV
       970        980        990       1000       1010       1020
YQLALIFTLL FVGEKMFQID SGRNAPLHSP PSEHYTIIFN TFVMMQLFNE INARKIHGER
      1030       1040       1050       1060       1070       1080
NVFDGIFRNP IFCTIVLGTF AIQIVIVQFG GKPFSCSPLQ LDQWMWCIFI GLGELVWGQV
      1090       1100       1110       1120       1130       1140
IATIPTSRLK FLKEAGRLTQ KEEIPEEELN EDVEEIDHAE RELRRGQILW FRGLNRIQTQ
      1150       1160       1170       1180       1190       1200
IRVVKAFRSS LYEGLEKPES RTSIHNFMAH PEFRIEDSQP HIPLIDDTDL EEDAALKQNS
      1210       1220       1230       1240
SPPSSLNKNN SAIDSGINLT TDTSKSATSS SPGSPIHSLE TSL         10         20         30         40         50         60
MGDMTNSDFY SKNQRNESSH GGEFGCTMEE LRSLMELRGT EAVVKIKETY GDTEAICRRL
        70         80         90        100        110        120
KTSPVEGLPG TAPDLEKRKQ IFGQNFIPPK KPKTFLQLVW EALQDVTLII LEIAAIISLG
       130        140        150        160        170        180
LSFYHPPGEG NEGCATAQGG AEDEGEAEAG WIEGAAILLS VICVVLVTAF NDWSKEKQFR
       190        200        210        220        230        240
GLQSRIEQEQ KFTVVRAGQV VQIPVAEIVV GDIAQVKYGD LLPADGLFIQ GNDLKIDESS
       250        260        270        280        290        300
LTGESDQVRK SVDKDPMLLS GTHVMEGSGR MLVTAVGVNS QTGIIFTLLG AGGEEEEKKD
       310        320        330        340        350        360
KKGVKKGDGL QLPAADGAAA SNAADSANAS LVNGKMQDGN VDASQSKAKQ QDGAAAMEMQ
       370        380        390        400        410        420
PLKSAEGGDA DDRKKASMHK KEKSVLQGKL TKLAVQIGKA GLVMSAITVI ILVLYFTVDT
       430        440        450        460        470        480
FVVNKKPWLP ECTPVYVQYF VKFFIIGVTV LVVAVPEGLP LAVTISLAYS VKKMMKDNNL
       490        500        510        520        530        540
VRHLDACETM GNATAICSDK TGTLTTNRMT VVQAYVGDVH YKEIPDPSSI NTKTMELLIN
       550        560        570        580        590        600
AIAINSAYTT KILPPEKEGA LPRQVGNKTE CGLLGFVLDL KQDYEPVRSQ MPEEKLYKVY
       610        620        630        640        650        660
TFNSVRKSMS TVIKLPDESF RMYSKGASEI VLKKCCKILN GAGEPRVFRP RDRDEMVKKV
       670        680        690        700        710        720
IEPMACDGLR TICVAYRDFP SSPEPDWDNE NDILNELTCI CVVGIEDPVR PEVPEAIRKC
       730        740        750        760        770        780
QRAGITVRMV TGDNINTARA IAIKCGIIHP GEDFLCLEGK EFNRRIRNEK GEIEQERIDK
       790        800        810        820        830        840
IWPKLRVLAR SSPTDKHTLV KGIIDSTHTE QRQVVAVTGD GTNDGPALKK ADVGFAMGIA
       850        860        870        880        890        900
GTDVAKEASD IILTDDNFSS IVKAVMWGRN VYDSISKFLQ FQLTVNVVAV IVAFTGACIT
       910        920        930        940        950        960
QDSPLKAVQM LWVNLIMDTF ASLALATEPP TETLLLRKPY GRNKPLISRT MMKNILGHAV
       970        980        990       1000       1010       1020
YQLALIFTLL FVGEKMFQID SGRNAPLHSP PSEHYTIIFN TFVMMQLFNE INARKIHGER
      1030       1040       1050       1060       1070       1080
NVFDGIFRNP IFCTIVLGTF AIQIVIVQFG GKPFSCSPLQ LDQWMWCIFI GLGELVWGQV
      1090       1100       1110       1120       1130       1140
IATIPTSRLK FLKEAGRLTQ KEEIPEEELN EDVEEIDHAE RELRRGQILW FRGLNRIQTQ
      1150       1160       1170       1180       1190       1200
IRVVKAFRSS LYEGLEKPES RTSIHNFMAH PEFRIEDSQP HIPLIDDTDL EEDAALKQNS
      1210       1220       1230       1240
SPPSSLNKNN SAIDSGINLT TDTSKSATSS SPGSPIHSLE TSL         10         20         30         40         50         60
MGDMTNSDFY SKNQRNESSH GGEFGCTMEE LRSLMELRGT EAVVKIKETY GDTEAICRRL
        70         80         90        100        110        120
KTSPVEGLPG TAPDLEKRKQ IFGQNFIPPK KPKTFLQLVW EALQDVTLII LEIAAIISLG
       130        140        150        160        170        180
LSFYHPPGEG NEGCATAQGG AEDEGEAEAG WIEGAAILLS VICVVLVTAF NDWSKEKQFR
       190        200        210        220        230        240
GLQSRIEQEQ KFTVVRAGQV VQIPVAEIVV GDIAQVKYGD LLPADGLFIQ GNDLKIDESS
       250        260        270        280        290        300
LTGESDQVRK SVDKDPMLLS GTHVMEGSGR MLVTAVGVNS QTGIIFTLLG AGGEEEEKKD
       310        320        330        340        350        360
KKGVKKGDGL QLPAADGAAA SNAADSANAS LVNGKMQDGN VDASQSKAKQ QDGAAAMEMQ
       370        380        390        400        410        420
PLKSAEGGDA DDRKKASMHK KEKSVLQGKL TKLAVQIGKA GLVMSAITVI ILVLYFTVDT
       430        440        450        460        470        480
FVVNKKPWLP ECTPVYVQYF VKFFIIGVTV LVVAVPEGLP LAVTISLAYS VKKMMKDNNL
       490        500        510        520        530        540
VRHLDACETM GNATAICSDK TGTLTTNRMT VVQAYVGDVH YKEIPDPSSI NTKTMELLIN
       550        560        570        580        590        600
AIAINSAYTT KILPPEKEGA LPRQVGNKTE CGLLGFVLDL KQDYEPVRSQ MPEEKLYKVY
       610        620        630        640        650        660
TFNSVRKSMS TVIKLPDESF RMYSKGASEI VLKKCCKILN GAGEPRVFRP RDRDEMVKKV
       670        680        690        700        710        720
IEPMACDGLR TICVAYRDFP SSPEPDWDNE NDILNELTCI CVVGIEDPVR PEVPEAIRKC
       730        740        750        760        770        780
QRAGITVRMV TGDNINTARA IAIKCGIIHP GEDFLCLEGK EFNRRIRNEK GEIEQERIDK
       790        800        810        820        830        840
IWPKLRVLAR SSPTDKHTLV KGIIDSTHTE QRQVVAVTGD GTNDGPALKK ADVGFAMGIA
       850        860        870        880        890        900
GTDVAKEASD IILTDDNFSS IVKAVMWGRN VYDSISKFLQ FQLTVNVVAV IVAFTGACIT
       910        920        930        940        950        960
QDSPLKAVQM LWVNLIMDTF ASLALATEPP TETLLLRKPY GRNKPLISRT MMKNILGHAV
       970        980        990       1000       1010       1020
YQLALIFTLL FVGEKMFQID SGRNAPLHSP PSEHYTIIFN TFVMMQLFNE INARKIHGER
      1030       1040       1050       1060       1070       1080
NVFDGIFRNP IFCTIVLGTF AIQIVIVQFG GKPFSCSPLQ LDQWMWCIFI GLGELVWGQV
      1090       1100       1110       1120       1130       1140
IATIPTSRLK FLKEAGRLTQ KEEIPEEELN EDVEEIDHAE RELRRGQILW FRGLNRIQTQ
      1150       1160       1170       1180       1190       1200
IRVVKAFRSS LYEGLEKPES RTSIHNFMAH PEFRIEDSQP HIPLIDDTDL EEDAALKQNS
      1210       1220       1230       1240
SPPSSLNKNN SAIDSGINLT TDTSKSATSS SPGSPIHSLE TSL         10         20         30         40         50         60
MGDMTNSDFY SKNQRNESSH GGEFGCTMEE LRSLMELRGT EAVVKIKETY GDTEAICRRL
        70         80         90        100        110        120
KTSPVEGLPG TAPDLEKRKQ IFGQNFIPPK KPKTFLQLVW EALQDVTLII LEIAAIISLG
       130        140        150        160        170        180
LSFYHPPGEG NEGCATAQGG AEDEGEAEAG WIEGAAILLS VICVVLVTAF NDWSKEKQFR
       190        200        210        220        230        240
GLQSRIEQEQ KFTVVRAGQV VQIPVAEIVV GDIAQVKYGD LLPADGLFIQ GNDLKIDESS
       250        260        270        280        290        300
LTGESDQVRK SVDKDPMLLS GTHVMEGSGR MLVTAVGVNS QTGIIFTLLG AGGEEEEKKD
       310        320        330        340        350        360
KKGVKKGDGL QLPAADGAAA SNAADSANAS LVNGKMQDGN VDASQSKAKQ QDGAAAMEMQ
       370        380        390        400        410        420
PLKSAEGGDA DDRKKASMHK KEKSVLQGKL TKLAVQIGKA GLVMSAITVI ILVLYFTVDT
       430        440        450        460        470        480
FVVNKKPWLP ECTPVYVQYF VKFFIIGVTV LVVAVPEGLP LAVTISLAYS VKKMMKDNNL
       490        500        510        520        530        540
VRHLDACETM GNATAICSDK TGTLTTNRMT VVQAYVGDVH YKEIPDPSSI NTKTMELLIN
       550        560        570        580        590        600
AIAINSAYTT KILPPEKEGA LPRQVGNKTE CGLLGFVLDL KQDYEPVRSQ MPEEKLYKVY
       610        620        630        640        650        660
TFNSVRKSMS TVIKLPDESF RMYSKGASEI VLKKCCKILN GAGEPRVFRP RDRDEMVKKV
       670        680        690        700        710        720
IEPMACDGLR TICVAYRDFP SSPEPDWDNE NDILNELTCI CVVGIEDPVR PEVPEAIRKC
       730        740        750        760        770        780
QRAGITVRMV TGDNINTARA IAIKCGIIHP GEDFLCLEGK EFNRRIRNEK GEIEQERIDK
       790        800        810        820        830        840
IWPKLRVLAR SSPTDKHTLV KGIIDSTHTE QRQVVAVTGD GTNDGPALKK ADVGFAMGIA
       850        860        870        880        890        900
GTDVAKEASD IILTDDNFSS IVKAVMWGRN VYDSISKFLQ FQLTVNVVAV IVAFTGACIT
       910        920        930        940        950        960
QDSPLKAVQM LWVNLIMDTF ASLALATEPP TETLLLRKPY GRNKPLISRT MMKNILGHAV
       970        980        990       1000       1010       1020
YQLALIFTLL FVGEKMFQID SGRNAPLHSP PSEHYTIIFN TFVMMQLFNE INARKIHGER
      1030       1040       1050       1060       1070       1080
NVFDGIFRNP IFCTIVLGTF AIQIVIVQFG GKPFSCSPLQ LDQWMWCIFI GLGELVWGQV
      1090       1100       1110       1120       1130       1140
IATIPTSRLK FLKEAGRLTQ KEEIPEEELN EDVEEIDHAE RELRRGQILW FRGLNRIQTQ
      1150       1160       1170       1180       1190       1200
IRVVKAFRSS LYEGLEKPES RTSIHNFMAH PEFRIEDSQP HIPLIDDTDL EEDAALKQNS
      1210       1220       1230       1240
SPPSSLNKNN SAIDSGINLT TDTSKSATSS SPGSPIHSLE TSL         10         20         30         40         50         60
MGDMTNSDFY SKNQRNESSH GGEFGCTMEE LRSLMELRGT EAVVKIKETY GDTEAICRRL
        70         80         90        100        110        120
KTSPVEGLPG TAPDLEKRKQ IFGQNFIPPK KPKTFLQLVW EALQDVTLII LEIAAIISLG
       130        140        150        160        170        180
LSFYHPPGEG NEGCATAQGG AEDEGEAEAG WIEGAAILLS VICVVLVTAF NDWSKEKQFR
       190        200        210        220        230        240
GLQSRIEQEQ KFTVVRAGQV VQIPVAEIVV GDIAQVKYGD LLPADGLFIQ GNDLKIDESS
       250        260        270        280        290        300
LTGESDQVRK SVDKDPMLLS GTHVMEGSGR MLVTAVGVNS QTGIIFTLLG AGGEEEEKKD
       310        320        330        340        350        360
KKGVKKGDGL QLPAADGAAA SNAADSANAS LVNGKMQDGN VDASQSKAKQ QDGAAAMEMQ
       370        380        390        400        410        420
PLKSAEGGDA DDRKKASMHK KEKSVLQGKL TKLAVQIGKA GLVMSAITVI ILVLYFTVDT
       430        440        450        460        470        480
FVVNKKPWLP ECTPVYVQYF VKFFIIGVTV LVVAVPEGLP LAVTISLAYS VKKMMKDNNL
       490        500        510        520        530        540
VRHLDACETM GNATAICSDK TGTLTTNRMT VVQAYVGDVH YKEIPDPSSI NTKTMELLIN
       550        560        570        580        590        600
AIAINSAYTT KILPPEKEGA LPRQVGNKTE CGLLGFVLDL KQDYEPVRSQ MPEEKLYKVY
       610        620        630        640        650        660
TFNSVRKSMS TVIKLPDESF RMYSKGASEI VLKKCCKILN GAGEPRVFRP RDRDEMVKKV
       670        680        690        700        710        720
IEPMACDGLR TICVAYRDFP SSPEPDWDNE NDILNELTCI CVVGIEDPVR PEVPEAIRKC
       730        740        750        760        770        780
QRAGITVRMV TGDNINTARA IAIKCGIIHP GEDFLCLEGK EFNRRIRNEK GEIEQERIDK
       790        800        810        820        830        840
IWPKLRVLAR SSPTDKHTLV KGIIDSTHTE QRQVVAVTGD GTNDGPALKK ADVGFAMGIA
       850        860        870        880        890        900
GTDVAKEASD IILTDDNFSS IVKAVMWGRN VYDSISKFLQ FQLTVNVVAV IVAFTGACIT
       910        920        930        940        950        960
QDSPLKAVQM LWVNLIMDTF ASLALATEPP TETLLLRKPY GRNKPLISRT MMKNILGHAV
       970        980        990       1000       1010       1020
YQLALIFTLL FVGEKMFQID SGRNAPLHSP PSEHYTIIFN TFVMMQLFNE INARKIHGER
      1030       1040       1050       1060       1070       1080
NVFDGIFRNP IFCTIVLGTF AIQIVIVQFG GKPFSCSPLQ LDQWMWCIFI GLGELVWGQV
      1090       1100       1110       1120       1130       1140
IATIPTSRLK FLKEAGRLTQ KEEIPEEELN EDVEEIDHAE RELRRGQILW FRGLNRIQTQ
      1150       1160       1170       1180       1190       1200
IRVVKAFRSS LYEGLEKPES RTSIHNFMAH PEFRIEDSQP HIPLIDDTDL EEDAALKQNS
      1210       1220       1230       1240
SPPSSLNKNN SAIDSGINLT TDTSKSATSS SPGSPIHSLE TSL         10         20         30         40         50         60
MGDMTNSDFY SKNQRNESSH GGEFGCTMEE LRSLMELRGT EAVVKIKETY GDTEAICRRL
        70         80         90        100        110        120
KTSPVEGLPG TAPDLEKRKQ IFGQNFIPPK KPKTFLQLVW EALQDVTLII LEIAAIISLG
       130        140        150        160        170        180
LSFYHPPGEG NEGCATAQGG AEDEGEAEAG WIEGAAILLS VICVVLVTAF NDWSKEKQFR
       190        200        210        220        230        240
GLQSRIEQEQ KFTVVRAGQV VQIPVAEIVV GDIAQVKYGD LLPADGLFIQ GNDLKIDESS
       250        260        270        280        290        300
LTGESDQVRK SVDKDPMLLS GTHVMEGSGR MLVTAVGVNS QTGIIFTLLG AGGEEEEKKD
       310        320        330        340        350        360
KKGVKKGDGL QLPAADGAAA SNAADSANAS LVNGKMQDGN VDASQSKAKQ QDGAAAMEMQ
       370        380        390        400        410        420
PLKSAEGGDA DDRKKASMHK KEKSVLQGKL TKLAVQIGKA GLVMSAITVI ILVLYFTVDT
       430        440        450        460        470        480
FVVNKKPWLP ECTPVYVQYF VKFFIIGVTV LVVAVPEGLP LAVTISLAYS VKKMMKDNNL
       490        500        510        520        530        540
VRHLDACETM GNATAICSDK TGTLTTNRMT VVQAYVGDVH YKEIPDPSSI NTKTMELLIN
       550        560        570        580        590        600
AIAINSAYTT KILPPEKEGA LPRQVGNKTE CGLLGFVLDL KQDYEPVRSQ MPEEKLYKVY
       610        620        630        640        650        660
TFNSVRKSMS TVIKLPDESF RMYSKGASEI VLKKCCKILN GAGEPRVFRP RDRDEMVKKV
       670        680        690        700        710        720
IEPMACDGLR TICVAYRDFP SSPEPDWDNE NDILNELTCI CVVGIEDPVR PEVPEAIRKC
       730        740        750        760        770        780
QRAGITVRMV TGDNINTARA IAIKCGIIHP GEDFLCLEGK EFNRRIRNEK GEIEQERIDK
       790        800        810        820        830        840
IWPKLRVLAR SSPTDKHTLV KGIIDSTHTE QRQVVAVTGD GTNDGPALKK ADVGFAMGIA
       850        860        870        880        890        900
GTDVAKEASD IILTDDNFSS IVKAVMWGRN VYDSISKFLQ FQLTVNVVAV IVAFTGACIT
       910        920        930        940        950        960
QDSPLKAVQM LWVNLIMDTF ASLALATEPP TETLLLRKPY GRNKPLISRT MMKNILGHAV
       970        980        990       1000       1010       1020
YQLALIFTLL FVGEKMFQID SGRNAPLHSP PSEHYTIIFN TFVMMQLFNE INARKIHGER
      1030       1040       1050       1060       1070       1080
NVFDGIFRNP IFCTIVLGTF AIQIVIVQFG GKPFSCSPLQ LDQWMWCIFI GLGELVWGQV
      1090       1100       1110       1120       1130       1140
IATIPTSRLK FLKEAGRLTQ KEEIPEEELN EDVEEIDHAE RELRRGQILW FRGLNRIQTQ
      1150       1160       1170       1180       1190       1200
IRVVKAFRSS LYEGLEKPES RTSIHNFMAH PEFRIEDSQP HIPLIDDTDL EEDAALKQNS
      1210       1220       1230       1240
SPPSSLNKNN SAIDSGINLT TDTSKSATSS SPGSPIHSLE TSL         10         20         30         40         50         60
MGDMTNSDFY SKNQRNESSH GGEFGCTMEE LRSLMELRGT EAVVKIKETY GDTEAICRRL
        70         80         90        100        110        120
KTSPVEGLPG TAPDLEKRKQ IFGQNFIPPK KPKTFLQLVW EALQDVTLII LEIAAIISLG
       130        140        150        160        170        180
LSFYHPPGEG NEGCATAQGG AEDEGEAEAG WIEGAAILLS VICVVLVTAF NDWSKEKQFR
       190        200        210        220        230        240
GLQSRIEQEQ KFTVVRAGQV VQIPVAEIVV GDIAQVKYGD LLPADGLFIQ GNDLKIDESS
       250        260        270        280        290        300
LTGESDQVRK SVDKDPMLLS GTHVMEGSGR MLVTAVGVNS QTGIIFTLLG AGGEEEEKKD
       310        320        330        340        350        360
KKGVKKGDGL QLPAADGAAA SNAADSANAS LVNGKMQDGN VDASQSKAKQ QDGAAAMEMQ
       370        380        390        400        410        420
PLKSAEGGDA DDRKKASMHK KEKSVLQGKL TKLAVQIGKA GLVMSAITVI ILVLYFTVDT
       430        440        450        460        470        480
FVVNKKPWLP ECTPVYVQYF VKFFIIGVTV LVVAVPEGLP LAVTISLAYS VKKMMKDNNL
       490        500        510        520        530        540
VRHLDACETM GNATAICSDK TGTLTTNRMT VVQAYVGDVH YKEIPDPSSI NTKTMELLIN
       550        560        570        580        590        600
AIAINSAYTT KILPPEKEGA LPRQVGNKTE CGLLGFVLDL KQDYEPVRSQ MPEEKLYKVY
       610        620        630        640        650        660
TFNSVRKSMS TVIKLPDESF RMYSKGASEI VLKKCCKILN GAGEPRVFRP RDRDEMVKKV
       670        680        690        700        710        720
IEPMACDGLR TICVAYRDFP SSPEPDWDNE NDILNELTCI CVVGIEDPVR PEVPEAIRKC
       730        740        750        760        770        780
QRAGITVRMV TGDNINTARA IAIKCGIIHP GEDFLCLEGK EFNRRIRNEK GEIEQERIDK
       790        800        810        820        830        840
IWPKLRVLAR SSPTDKHTLV KGIIDSTHTE QRQVVAVTGD GTNDGPALKK ADVGFAMGIA
       850        860        870        880        890        900
GTDVAKEASD IILTDDNFSS IVKAVMWGRN VYDSISKFLQ FQLTVNVVAV IVAFTGACIT
       910        920        930        940        950        960
QDSPLKAVQM LWVNLIMDTF ASLALATEPP TETLLLRKPY GRNKPLISRT MMKNILGHAV
       970        980        990       1000       1010       1020
YQLALIFTLL FVGEKMFQID SGRNAPLHSP PSEHYTIIFN TFVMMQLFNE INARKIHGER
      1030       1040       1050       1060       1070       1080
NVFDGIFRNP IFCTIVLGTF AIQIVIVQFG GKPFSCSPLQ LDQWMWCIFI GLGELVWGQV
      1090       1100       1110       1120       1130       1140
IATIPTSRLK FLKEAGRLTQ KEEIPEEELN EDVEEIDHAE RELRRGQILW FRGLNRIQTQ
      1150       1160       1170       1180       1190       1200
IRVVKAFRSS LYEGLEKPES RTSIHNFMAH PEFRIEDSQP HIPLIDDTDL EEDAALKQNS
      1210       1220       1230       1240
SPPSSLNKNN SAIDSGINLT TDTSKSATSS SPGSPIHSLE TSL

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 4 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q01814-1-unknown	MGDMTN...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q01814-1-unknown	MGDMTN...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt67763
Q01814-1-unknown	MGDMTN...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt67764
Q01814-1-unknown	MGDMTN...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt67765
Q01814-1-unknown	MGDMTN...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt67766
Q01814-1-unknown	MGDMTN...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt67767
Q01814-1-unknown	MGDMTN...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt67768
Q01814-1-unknown	MGDMTN...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt67769
Q01814-1118-unknown	HAEREL...	1118	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2894
Q01814-1118-unknown	HAEREL...	1118	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2004
Q01814-1118-unknown	HAEREL...	1118	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1269
Q01814-1118-unknown	HAEREL...	1118	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt157308
Q01814-1118-unknown	HAEREL...	1118	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt157309
Q01814-1118-unknown	HAEREL...	1118	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt157340
Q01814-1118-unknown	HAEREL...	1118	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt157341
Q01814-1118-unknown	HAEREL...	1118	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt157384
Q01814-1118-unknown	HAEREL...	1118	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt157385
Q01814-1118-unknown	HAEREL...	1118	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt157435
Q01814-1125-unknown	RGQILW...	1125	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC804
Q01814-1125-unknown	RGQILW...	1125	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt157323
Q01814-1125-unknown	RGQILW...	1125	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt157358
Q01814-1125-unknown	RGQILW...	1125	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt157422
Q01814-1136-unknown	RIQTQI...	1136	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC812
Q01814-1136-unknown	RIQTQI...	1136	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt157353
Q01814-1136-unknown	RIQTQI...	1136	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt157386
Q01814-1136-unknown	RIQTQI...	1136	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt157452

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VEEIDH	1117	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2894
...VEEIDH	1117	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2004
...VEEIDH	1117	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1269
...VEEIDH	1117	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140807
...VEEIDH	1117	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140808
...VEEIDH	1117	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140839
...VEEIDH	1117	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140840
...VEEIDH	1117	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140883
...VEEIDH	1117	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140884
...VEEIDH	1117	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140933
...ERELRR	1124	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC804
...ERELRR	1124	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140822
...ERELRR	1124	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140823
...ERELRR	1124	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140857
...ERELRR	1124	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140858
...ERELRR	1124	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140920
...ERELRR	1124	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140921
...ERELRR	1124	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140958
...FRGLNR	1135	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC812
...FRGLNR	1135	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140852
...FRGLNR	1135	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140885
...FRGLNR	1135	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140950
...LETSL	1243	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...LETSL	1243	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt63385
...LETSL	1243	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt63387
...LETSL	1243	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt63384

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP7_HUMAN	1117	EIDH.\|.HAER	inferred from experiment	unknown	MEROPS	Nicotera P	Schwab BL et al.:Cleavage of plasma membrane cal... (C14.001)	12107825,
CASP3_HUMAN	1117	EIDH.\|.HAER	inferred from experiment	unknown	MEROPS	Nicotera P	Schwab BL et al.:Cleavage of plasma membrane cal... (C14.001)	12107825,
CASP1_HUMAN	1117	EIDH.\|.HAER	inferred from experiment	unknown	MEROPS	Nicotera P	Schwab BL et al.:Cleavage of plasma membrane cal... (C14.001)	12107825,
CAN1_HUMAN	1124	ELRR.\|.RGQI	inferred from experiment	unknown	MEROPS	Carafoli E	James P et al.:Modulation of erythrocyte Ca2+-... (C02.001)	2542272,
CAN1_HUMAN	1135	GLNR.\|.RIQT	inferred from experiment	unknown	MEROPS	Carafoli E	James P et al.:Modulation of erythrocyte Ca2+-... (C02.001)	2542272,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)