P17252: Protein kinase C alpha type

General Information

Protein names	- Protein kinase C alpha type - PKC-A - PKC-alpha - 2.7.11.13
Gene names	PRKCA
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P17252

6 N-termini

5 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MADVFPGNDS TASQDVANRF ARKGALRQKN VHEVKDHKFI ARFFKQPTFC SHCTDFIWGF
        70         80         90        100        110        120
GKQGFQCQVC CFVVHKRCHE FVTFSCPGAD KGPDTDDPRS KHKFKIHTYG SPTFCDHCGS
       130        140        150        160        170        180
LLYGLIHQGM KCDTCDMNVH KQCVINVPSL CGMDHTEKRG RIYLKAEVAD EKLHVTVRDA
       190        200        210        220        230        240
KNLIPMDPNG LSDPYVKLKL IPDPKNESKQ KTKTIRSTLN PQWNESFTFK LKPSDKDRRL
       250        260        270        280        290        300
SVEIWDWDRT TRNDFMGSLS FGVSELMKMP ASGWYKLLNQ EEGEYYNVPI PEGDEEGNME
       310        320        330        340        350        360
LRQKFEKAKL GPAGNKVISP SEDRKQPSNN LDRVKLTDFN FLMVLGKGSF GKVMLADRKG
       370        380        390        400        410        420
TEELYAIKIL KKDVVIQDDD VECTMVEKRV LALLDKPPFL TQLHSCFQTV DRLYFVMEYV
       430        440        450        460        470        480
NGGDLMYHIQ QVGKFKEPQA VFYAAEISIG LFFLHKRGII YRDLKLDNVM LDSEGHIKIA
       490        500        510        520        530        540
DFGMCKEHMM DGVTTRTFCG TPDYIAPEII AYQPYGKSVD WWAYGVLLYE MLAGQPPFDG
       550        560        570        580        590        600
EDEDELFQSI MEHNVSYPKS LSKEAVSVCK GLMTKHPAKR LGCGPEGERD VREHAFFRRI
       610        620        630        640        650        660
DWEKLENREI QPPFKPKVCG KGAENFDKFF TRGQPVLTPP DQLVIANIDQ SDFEGFSYVN
       670
PQFVHPILQS AV

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

6 N-termini - 5 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P17252-2-unknown	MADVFP...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P17252-2-Acetylation	ADVFPG...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P17252-2-Acetylation	ADVFPG...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P17252-2-Acetylation	ADVFPG...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P17252-310-unknown	LGPAGN...	310		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC736
P17252-317-unknown	VISPSE...	317		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC737
P17252-325-unknown	KQPSNN...	325		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC738
P17252-379-unknown	DDVECT...	379		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11260

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...FEKAKL	309	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC736
...PAGNKV	316	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC737
...PSEDRK	324	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC738
...VVIQDD	378	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11260
...LQSAV	672	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CAN1_HUMAN	309	KAKL.\|.LGPA	inferred from experiment	unknown	MEROPS	Nishizuka Y	Kishimoto A et al.:Limited proteolysis of protein ... (C02.001)	2537303,
CAN1_HUMAN	316	GNKV.\|.VISP	inferred from experiment	unknown	MEROPS	Nishizuka Y	Kishimoto A et al.:Limited proteolysis of protein ... (C02.001)	2537303,
CAN1_HUMAN	324	EDRK.\|.KQPS	inferred from experiment	unknown	MEROPS	Nishizuka Y	Kishimoto A et al.:Limited proteolysis of protein ... (C02.001)	2537303,
GRAB_HUMAN	378	IQDD.\|.DDVE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)