Q13813: Spectrin alpha chain, non-erythrocytic 1

General Information

Protein names	- Spectrin alpha chain, non-erythrocytic 1 - Alpha-II spectrin - Fodrin alpha chain - Spectrin, non-erythroid alpha subunit
Gene names	SPTAN1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q13813

25 N-termini

12 C-termini

15 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Spectrin alpha chain, non-erythrocytic 1 - Isoform 3 of Spectrin alpha chain, non-erythrocytic 1

Sequence View

        10         20         30         40         50         60
MDPSGVKVLE TAEDIQERRQ QVLDRYHRFK ELSTLRRQKL EDSYRFQFFQ RDAEELEKWI
        70         80         90        100        110        120
QEKLQIASDE NYKDPTNLQG KLQKHQAFEA EVQANSGAIV KLDETGNLMI SEGHFASETI
       130        140        150        160        170        180
RTRLMELHRQ WELLLEKMRE KGIKLLQAQK LVQYLRECED VMDWINDKEA IVTSEELGQD
       190        200        210        220        230        240
LEHVEVLQKK FEEFQTDMAA HEERVNEVNQ FAAKLIQEQH PEEELIKTKQ DEVNAAWQRL
       250        260        270        280        290        300
KGLALQRQGK LFGAAEVQRF NRDVDETISW IKEKEQLMAS DDFGRDLASV QALLRKHEGL
       310        320        330        340        350        360
ERDLAALEDK VKALCAEADR LQQSHPLSAT QIQVKREELI TNWEQIRTLA AERHARLNDS
       370        380        390        400        410        420
YRLQRFLADF RDLTSWVTEM KALINADELA SDVAGAEALL DRHQEHKGEI DAHEDSFKSA
       430        440        450        460        470        480
DESGQALLAA GHYASDEVRE KLTVLSEERA ALLELWELRR QQYEQCMDLQ LFYRDTEQVD
       490        500        510        520        530        540
NWMSKQEAFL LNEDLGDSLD SVEALLKKHE DFEKSLSAQE EKITALDEFA TKLIQNNHYA
       550        560        570        580        590        600
MEDVATRRDA LLSRRNALHE RAMRRRAQLA DSFHLQQFFR DSDELKSWVN EKMKTATDEA
       610        620        630        640        650        660
YKDPSNLQGK VQKHQAFEAE LSANQSRIDA LEKAGQKLID VNHYAKDEVA ARMNEVISLW
       670        680        690        700        710        720
KKLLEATELK GIKLREANQQ QQFNRNVEDI ELWLYEVEGH LASDDYGKDL TNVQNLQKKH
       730        740        750        760        770        780
ALLEADVAAH QDRIDGITIQ ARQFQDAGHF DAENIKKKQE ALVARYEALK EPMVARKQKL
       790        800        810        820        830        840
ADSLRLQQLF RDVEDEETWI REKEPIAAST NRGKDLIGVQ NLLKKHQALQ AEIAGHEPRI
       850        860        870        880        890        900
KAVTQKGNAM VEEGHFAAED VKAKLHELNQ KWEALKAKAS QRRQDLEDSL QAQQYFADAN
       910        920        930        940        950        960
EAESWMREKE PIVGSTDYGK DEDSAEALLK KHEALMSDLS AYGSSIQALR EQAQSCRQQV
       970        980        990       1000       1010       1020
APTDDETGKE LVLALYDYQE KSPREVTMKK GDILTLLNST NKDWWKVEVN DRQGFVPAAY
      1030       1040       1050       1060       1070       1080
VKKLDPAQSA SRENLLEEQG SIALRQEQID NQTRITKEAG SVSLRMKQVE ELYHSLLELG
      1090       1100       1110       1120       1130       1140
EKRKGMLEKS CKKFMLFREA NELQQWINEK EAALTSEEVG ADLEQVEVLQ KKFDDFQKDL
      1150       1160       1170       1180       1190       1200
KANESRLKDI NKVAEDLESE GLMAEEVQAV QQQEVYGMMP RDETDSKTAS PWKSARLMVH
      1210       1220       1230       1240       1250       1260
TVATFNSIKE LNERWRSLQQ LAEERSQLLG SAHEVQRFHR DADETKEWIE EKNQALNTDN
      1270       1280       1290       1300       1310       1320
YGHDLASVQA LQRKHEGFER DLAALGDKVN SLGETAERLI QSHPESAEDL QEKCTELNQA
      1330       1340       1350       1360       1370       1380
WSSLGKRADQ RKAKLGDSHD LQRFLSDFRD LMSWINGIRG LVSSDELAKD VTGAEALLER
      1390       1400       1410       1420       1430       1440
HQEHRTEIDA RAGTFQAFEQ FGQQLLAHGH YASPEIKQKL DILDQERADL EKAWVQRRMM
      1450       1460       1470       1480       1490       1500
LDQCLELQLF HRDCEQAENW MAAREAFLNT EDKGDSLDSV EALIKKHEDF DKAINVQEEK
      1510       1520       1530       1540       1550       1560
IAALQAFADQ LIAAGHYAKG DISSRRNEVL DRWRRLKAQM IEKRSKLGES QTLQQFSRDV
      1570       1580       1590       1600       1610       1620
DEIEAWISEK LQTASDESYK DPTNIQSKHQ KHQAFEAELH ANADRIRGVI DMGNSLIERG
      1630       1640       1650       1660       1670       1680
ACAGSEDAVK ARLAALADQW QFLVQKSAEK SQKLKEANKQ QNFNTGIKDF DFWLSEVEAL
      1690       1700       1710       1720       1730       1740
LASEDYGKDL ASVNNLLKKH QLLEADISAH EDRLKDLNSQ ADSLMTSSAF DTSQVKDKRD
      1750       1760       1770       1780       1790       1800
TINGRFQKIK SMAASRRAKL NESHRLHQFF RDMDDEESWI KEKKLLVGSE DYGRDLTGVQ
      1810       1820       1830       1840       1850       1860
NLRKKHKRLE AELAAHEPAI QGVLDTGKKL SDDNTIGKEE IQQRLAQFVE HWKELKQLAA
      1870       1880       1890       1900       1910       1920
ARGQRLEESL EYQQFVANVE EEEAWINEKM TLVASEDYGD TLAAIQGLLK KHEAFETDFT
      1930       1940       1950       1960       1970       1980
VHKDRVNDVC TNGQDLIKKN NHHEENISSK MKGLNGKVSD LEKAAAQRKA KLDENSAFLQ
      1990       2000       2010       2020       2030       2040
FNWKADVVES WIGEKENSLK TDDYGRDLSS VQTLLTKQET FDAGLQAFQQ EGIANITALK
      2050       2060       2070       2080       2090       2100
DQLLAAKHVQ SKAIEARHAS LMKRWSQLLA NSAARKKKLL EAQSHFRKVE DLFLTFAKKA
      2110       2120       2130       2140       2150       2160
SAFNSWFENA EEDLTDPVRC NSLEEIKALR EAHDAFRSSL SSAQADFNQL AELDRQIKSF
      2170       2180       2190       2200       2210       2220
RVASNPYTWF TMEALEETWR NLQKIIKERE LELQKEQRRQ EENDKLRQEF AQHANAFHQW
      2230       2240       2250       2260       2270       2280
IQETRTYLLD GSCMVEESGT LESQLEATKR KHQEIRAMRS QLKKIEDLGA AMEEALILDN
      2290       2300       2310       2320       2330       2340
KYTEHSTVGL AQQWDQLDQL GMRMQHNLEQ QIQARNTTGV TEEALKEFSM MFKHFDKDKS
      2350       2360       2370       2380       2390       2400
GRLNHQEFKS CLRSLGYDLP MVEEGEPDPE FEAILDTVDP NRDGHVSLQE YMAFMISRET
      2410       2420       2430       2440       2450       2460
ENVKSSEEIE SAFRALSSEG KPYVTKEELY QNLTREQADY CVSHMKPYVD GKGRELPTAF
      2470
DYVEFTRSLF VN         10         20         30         40         50         60
MDPSGVKVLE TAEDIQERRQ QVLDRYHRFK ELSTLRRQKL EDSYRFQFFQ RDAEELEKWI
        70         80         90        100        110        120
QEKLQIASDE NYKDPTNLQG KLQKHQAFEA EVQANSGAIV KLDETGNLMI SEGHFASETI
       130        140        150        160        170        180
RTRLMELHRQ WELLLEKMRE KGIKLLQAQK LVQYLRECED VMDWINDKEA IVTSEELGQD
       190        200        210        220        230        240
LEHVEVLQKK FEEFQTDMAA HEERVNEVNQ FAAKLIQEQH PEEELIKTKQ DEVNAAWQRL
       250        260        270        280        290        300
KGLALQRQGK LFGAAEVQRF NRDVDETISW IKEKEQLMAS DDFGRDLASV QALLRKHEGL
       310        320        330        340        350        360
ERDLAALEDK VKALCAEADR LQQSHPLSAT QIQVKREELI TNWEQIRTLA AERHARLNDS
       370        380        390        400        410        420
YRLQRFLADF RDLTSWVTEM KALINADELA SDVAGAEALL DRHQEHKGEI DAHEDSFKSA
       430        440        450        460        470        480
DESGQALLAA GHYASDEVRE KLTVLSEERA ALLELWELRR QQYEQCMDLQ LFYRDTEQVD
       490        500        510        520        530        540
NWMSKQEAFL LNEDLGDSLD SVEALLKKHE DFEKSLSAQE EKITALDEFA TKLIQNNHYA
       550        560        570        580        590        600
MEDVATRRDA LLSRRNALHE RAMRRRAQLA DSFHLQQFFR DSDELKSWVN EKMKTATDEA
       610        620        630        640        650        660
YKDPSNLQGK VQKHQAFEAE LSANQSRIDA LEKAGQKLID VNHYAKDEVA ARMNEVISLW
       670        680        690        700        710        720
KKLLEATELK GIKLREANQQ QQFNRNVEDI ELWLYEVEGH LASDDYGKDL TNVQNLQKKH
       730        740        750        760        770        780
ALLEADVAAH QDRIDGITIQ ARQFQDAGHF DAENIKKKQE ALVARYEALK EPMVARKQKL
       790        800        810        820        830        840
ADSLRLQQLF RDVEDEETWI REKEPIAAST NRGKDLIGVQ NLLKKHQALQ AEIAGHEPRI
       850        860        870        880        890        900
KAVTQKGNAM VEEGHFAAED VKAKLHELNQ KWEALKAKAS QRRQDLEDSL QAQQYFADAN
       910        920        930        940        950        960
EAESWMREKE PIVGSTDYGK DEDSAEALLK KHEALMSDLS AYGSSIQALR EQAQSCRQQV
       970        980        990       1000       1010       1020
APTDDETGKE LVLALYDYQE KSPREVTMKK GDILTLLNST NKDWWKVEVN DRQGFVPAAY
      1030       1040       1050       1060       1070       1080
VKKLDPAQSA SRENLLEEQG SIALRQEQID NQTRITKEAG SVSLRMKQVE ELYHSLLELG
      1090       1100       1110       1120       1130       1140
EKRKGMLEKS CKKFMLFREA NELQQWINEK EAALTSEEVG ADLEQVEVLQ KKFDDFQKDL
      1150       1160       1170       1180       1190       1200
KANESRLKDI NKVAEDLESE GLMAEEVQAV QQQEVYGMMP RDETDSKTAS PWKSARLMVH
      1210       1220       1230       1240       1250       1260
TVATFNSIKE LNERWRSLQQ LAEERSQLLG SAHEVQRFHR DADETKEWIE EKNQALNTDN
      1270       1280       1290       1300       1310       1320
YGHDLASVQA LQRKHEGFER DLAALGDKVN SLGETAERLI QSHPESAEDL QEKCTELNQA
      1330       1340       1350       1360       1370       1380
WSSLGKRADQ RKAKLGDSHD LQRFLSDFRD LMSWINGIRG LVSSDELAKD VTGAEALLER
      1390       1400       1410       1420       1430       1440
HQEHRTEIDA RAGTFQAFEQ FGQQLLAHGH YASPEIKQKL DILDQERADL EKAWVQRRMM
      1450       1460       1470       1480       1490       1500
LDQCLELQLF HRDCEQAENW MAAREAFLNT EDKGDSLDSV EALIKKHEDF DKAINVQEEK
      1510       1520       1530       1540       1550       1560
IAALQAFADQ LIAAGHYAKG DISSRRNEVL DRWRRLKAQM IEKRSKLGES QTLQQFSRDV
      1570       1580       1590       1600       1610       1620
DEIEAWISEK LQTASDESYK DPTNIQSKHQ KHQAFEAELH ANADRIRGVI DMGNSLIERG
      1630       1640       1650       1660       1670       1680
ACAGSEDAVK ARLAALADQW QFLVQKSAEK SQKLKEANKQ QNFNTGIKDF DFWLSEVEAL
      1690       1700       1710       1720       1730       1740
LASEDYGKDL ASVNNLLKKH QLLEADISAH EDRLKDLNSQ ADSLMTSSAF DTSQVKDKRD
      1750       1760       1770       1780       1790       1800
TINGRFQKIK SMAASRRAKL NESHRLHQFF RDMDDEESWI KEKKLLVGSE DYGRDLTGVQ
      1810       1820       1830       1840       1850       1860
NLRKKHKRLE AELAAHEPAI QGVLDTGKKL SDDNTIGKEE IQQRLAQFVE HWKELKQLAA
      1870       1880       1890       1900       1910       1920
ARGQRLEESL EYQQFVANVE EEEAWINEKM TLVASEDYGD TLAAIQGLLK KHEAFETDFT
      1930       1940       1950       1960       1970       1980
VHKDRVNDVC TNGQDLIKKN NHHEENISSK MKGLNGKVSD LEKAAAQRKA KLDENSAFLQ
      1990       2000       2010       2020       2030       2040
FNWKADVVES WIGEKENSLK TDDYGRDLSS VQTLLTKQET FDAGLQAFQQ EGIANITALK
      2050       2060       2070       2080       2090       2100
DQLLAAKHVQ SKAIEARHAS LMKRWSQLLA NSAARKKKLL EAQSHFRKVE DLFLTFAKKA
      2110       2120       2130       2140       2150       2160
SAFNSWFENA EEDLTDPVRC NSLEEIKALR EAHDAFRSSL SSAQADFNQL AELDRQIKSF
      2170       2180       2190       2200       2210       2220
RVASNPYTWF TMEALEETWR NLQKIIKERE LELQKEQRRQ EENDKLRQEF AQHANAFHQW
      2230       2240       2250       2260       2270       2280
IQETRTYLLD GSCMVEESGT LESQLEATKR KHQEIRAMRS QLKKIEDLGA AMEEALILDN
      2290       2300       2310       2320       2330       2340
KYTEHSTVGL AQQWDQLDQL GMRMQHNLEQ QIQARNTTGV TEEALKEFSM MFKHFDKDKS
      2350       2360       2370       2380       2390       2400
GRLNHQEFKS CLRSLGYDLP MVEEGEPDPE FEAILDTVDP NRDGHVSLQE YMAFMISRET
      2410       2420       2430       2440       2450       2460
ENVKSSEEIE SAFRALSSEG KPYVTKEELY QNLTREQADY CVSHMKPYVD GKGRELPTAF
      2470
DYVEFTRSLF VN

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

25 N-termini - 12 C-termini - 15 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q13813-1-Acetylation	MDPSGV...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q13813-1-Acetylation	MDPSGV...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q13813-1-Acetylation	MDPSGV...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q13813-1-Acetylation	MDPSGV...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt100715
Q13813-1-Acetylation	MDPSGV...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt100716
Q13813-1-unknown	MDPSGV...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt90573
Q13813-1-unknown	MDPSGV...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt90574
Q13813-103-unknown	DETGNL...	103		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17922
Q13813-103-unknown	DETGNL...	103		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt142518
Q13813-103-unknown	DETGNL...	103		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt142520
Q13813-218-unknown	EQHPEE...	218		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6357
Q13813-218-unknown	EQHPEE...	218		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147287
Q13813-218-unknown	EQHPEE...	218		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147289
Q13813-501-unknown	SVEALL...	501		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172192
Q13813-501-unknown	SVEALL...	501		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172193
Q13813-501-	SVEALL...	501			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q13813-915-unknown	STDYGK...	915		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6360
Q13813-915-unknown	STDYGK...	915		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt156954
Q13813-915-unknown	STDYGK...	915		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt156955
Q13813-941-unknown	AYGSSI...	941		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175709
Q13813-941-unknown	AYGSSI...	941		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175710
Q13813-941-	AYGSSI...	941			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q13813-965-unknown	DETGKE...	965		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19477
Q13813-965-unknown	DETGKE...	965		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt157078
Q13813-965-unknown	DETGKE...	965		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt157079
Q13813-1177-	GMMPRD...	1177			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q13813-1177-unknown	GMMPRD...	1177		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC828
Q13813-1177-unknown	GMMPRD...	1177		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt157511
Q13813-1177-unknown	GMMPRD...	1177		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt157590
Q13813-1186-unknown	SKTASP...	1186		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1284
Q13813-1186-unknown	SKTASP...	1186		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2384
Q13813-1186-unknown	SKTASP...	1186		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2193
Q13813-1186-unknown	SKTASP...	1186		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt157523
Q13813-1186-unknown	SKTASP...	1186		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt157637
Q13813-1199-	VHTVAT...	1199			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q13813-1199-	VHTVAT...	1199			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q13813-1199-unknown	VHTVAT...	1199			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q13813-1199-unknown	VHTVAT...	1199		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162150
Q13813-1199-unknown	VHTVAT...	1199		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162151
Q13813-1302-unknown	SHPESA...	1302		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7790
Q13813-1302-unknown	SHPESA...	1302		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6363
Q13813-1302-unknown	SHPESA...	1302		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt157873
Q13813-1302-unknown	SHPESA...	1302		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt157900
Q13813-1309-unknown	DLQEKC...	1309		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19480
Q13813-1309-unknown	DLQEKC...	1309		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt157886
Q13813-1309-unknown	DLQEKC...	1309		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt157913
Q13813-1479-	SVEALI...	1479			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q13813-1479-	SVEALI...	1479			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q13813-1479-	SVEALI...	1479			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q13813-1479-	SVEALI...	1479			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q13813-1479-unknown	SVEALI...	1479		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2196
Q13813-1479-unknown	SVEALI...	1479		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt158138
Q13813-1479-unknown	SVEALI...	1479		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt158179
Q13813-1509-unknown	DQLIAA...	1509		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17925
Q13813-1509-unknown	DQLIAA...	1509		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19483
Q13813-1509-unknown	DQLIAA...	1509		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt158191
Q13813-1509-unknown	DQLIAA...	1509		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt158200
Q13813-1545-unknown	SKLGES...	1545		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10274
Q13813-1545-unknown	SKLGES...	1545		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt158218
Q13813-1545-unknown	SKLGES...	1545		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt158233
Q13813-1875-unknown	FVANVE...	1875		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172189
Q13813-1875-unknown	FVANVE...	1875		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172190
Q13813-1875-	FVANVE...	1875			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q13813-2105-	SWFENA...	2105			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q13813-2105-	SWFENA...	2105			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q13813-2105-	SWFENA...	2105			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q13813-2105-unknown	SWFENA...	2105		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173575
Q13813-2105-unknown	SWFENA...	2105		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173576

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...AIVKLD	102	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17922
...AIVKLD	102	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125713
...AIVKLD	102	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125715
...AKLIQE	217	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6357
...AKLIQE	217	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130630
...AKLIQE	217	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130632
...EPIVGS	914	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6360
...EPIVGS	914	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140445
...EPIVGS	914	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140446
...VAPTDD	964	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19477
...VAPTDD	964	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140576
...VAPTDD	964	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140577
...QQEVYG	1176	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC828
...QQEVYG	1176	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt141010
...QQEVYG	1176	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt141089
...RDETDS	1185	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1284
...RDETDS	1185	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2384
...RDETDS	1185	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2193
...RDETDS	1185	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt141022
...RDETDS	1185	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt141136
...ERLIQS	1301	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7790
...ERLIQS	1301	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6363
...ERLIQS	1301	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt141370
...ERLIQS	1301	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt141397
...PESAED	1308	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19480
...PESAED	1308	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt141383
...PESAED	1308	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt141408
...GDSLDS	1478	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2196
...GDSLDS	1478	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt141633
...GDSLDS	1478	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt141675
...LQAFAD	1508	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17925
...LQAFAD	1508	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19483
...LQAFAD	1508	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt141687
...LQAFAD	1508	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt141696
...MIEKRS	1544	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10274
...MIEKRS	1544	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt141714
...MIEKRS	1544	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt141729
...SLFVN	2472	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...SLFVN	2472	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt86192
...SLFVN	2472	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt86191

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	102	VKLD.\|.DETG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATL1_HUMAN	217	LIQE.\|.EQHP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	914	IVGS.\|.STDY	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	964	PTDD.\|.DETG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CAN1_HUMAN	1176	EVYG.\|.GMMP	inferred from experiment	unknown	MEROPS	Morrow JS	Stabach PR et al.:Site-directed mutagenesis of al... (C02.001)	8993318,
CASP1_HUMAN	1185	ETDS.\|.SKTA	inferred from experiment	unknown	MEROPS	Wang KK	Nath R et al.:Non-erythroid alpha-spectrin br... (C14.001)	8920967,
CASP4_HUMAN	1185	ETDS.\|.SKTA	inferred from experiment	unknown	MEROPS	Wang KK	Nath R et al.:Non-erythroid alpha-spectrin br... (C14.001)	8920967,
CASP3_HUMAN	1185	ETDS.\|.SKTA	inferred from experiment	unknown	MEROPS	Wang KK	Nath R et al.:Non-erythroid alpha-spectrin br... (C14.001)	8920967,
CATS_HUMAN	1301	LIQS.\|.SHPE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	1301	LIQS.\|.SHPE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	1308	SAED.\|.DLQE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CASP3_HUMAN	1478	SLDS.\|.SVEA	inferred from experiment	unknown	MEROPS	Morrow JS	Wang KK et al.:Simultaneous degradation of alp... (C14.003)	9712874,
MEP1A_HUMAN	1508	AFAD.\|.DQLI	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	1508	AFAD.\|.DQLI	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAA_HUMAN	1544	EKRS.\|.SKLG	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)