P61278: Somatostatin
| Protein names | - Somatostatin - Growth hormone release-inhibiting factor - Somatostatin-28 - Somatostatin-14 - SST-14 {ECO:0000303|PubMed:29615476} - Neuronostatin {ECO:0000303|PubMed:29615476} - NST {ECO:0000303|PubMed:29615476} |
|---|---|
| Gene names | SST |
| Organism | Homo sapiens |
| Protease Family | |
| Protease ID | |
| Chromosome location | |
| UniProt ID | P61278 |
3
N-termini
5
C-termini
6
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MLSCRLQCAL AALSIVLALG CVTGAPSDPR LRQFLQKSLA AAAGKQELAK YFLAELLSEP
70 80 90 100 110
NQTENDALEP EDLSQAAEQD EMRLELQRSA NSNPAMAPRE RKAGCKNFFW KTFTSC
Isoforms
Sequence View
Protein Neighborhood
Domains & Features
3 N-termini - 5 C-termini - 6 Cleavages - 0 Substrates
N-termini
| Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
|---|---|---|---|---|---|---|---|---|---|
| P61278-89-unknown | SANSNP... | 89 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC16365 | |||
| P61278-102-unknown | KAGCKN... | 102 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC26774 | |||
| P61278-102-unknown | KAGCKN... | 102 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC229 | |||
| P61278-109-unknown | FWKTFT... | 109 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15786 |
C-termini
| Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| ...LELQRS | 88 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC16365 | |||
| ...APRERK | 101 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC26774 | |||
| ...APRERK | 101 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC229 | |||
| ...GCKNFF | 108 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15786 | |||
| ...NFFWKT | 111 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC799 | |||
| ...FFWKTF | 112 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC1059 |
Cleavages
| Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| KLK4_HUMAN | 88 | LQRS.|.SANS | inferred from experiment | unknown | MEROPS | Nelson PS | Matsumura M et al.:Substrates of the prostate-spec... (S01.251) | 15389820, |
| NRDC_HUMAN | 101 | RERK.|.KAGC | inferred from experiment | unknown | MEROPS | Merops NRDC_HUMAN -> SMS_HUMAN @101 | ||
| AMPB_HUMAN | 101 | RERK.|.KAGC | inferred from experiment | unknown | MEROPS | Merops AMPB_HUMAN -> SMS_HUMAN @101 | ||
| IDE_HUMAN | 108 | KNFF.|.FWKT | inferred from experiment | unknown | MEROPS | Coletta M | Ciaccio C et al.:Somatostatin: a novel substrate... (M16.002) | 19073193, |
| CAN1_HUMAN | 111 | FWKT.|.TFTS | inferred from experiment | unknown | MEROPS | Pennington RJ | McDermott JR et al.:Specificity of neuropeptide deg... (C02.001) | 2410757, |
| CAN2_HUMAN | 112 | WKTF.|.FTSC | inferred from experiment | unknown | MEROPS | Pennington RJ | McDermott JR et al.:Specificity of neuropeptide deg... (C02.001) | 2410757, |
Substrates
| Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|