TopFIND 4.0

P17655: Calpain-2 catalytic subunit

General Information

Protein names
- Calpain-2 catalytic subunit
- 3.4.22.53
- Calcium-activated neutral proteinase 2
- CANP 2
- Calpain M-type
- Calpain large polypeptide L2
- Calpain-2 large subunit
- Millimolar-calpain
- M-calpain
Gene names CAPN2
Organism Homo sapiens
Protease Family C02.002
Protease ID C02.002
Chromosome location
UniProt ID P17655

6

N-termini

5

C-termini

4

Cleavages

225

Substrates

Sequence

        10         20         30         40         50         60 
MAGIAAKLAK DREAAEGLGS HDRAIKYLNQ DYEALRNECL EAGTLFQDPS FPAIPSALGF 
        70         80         90        100        110        120 
KELGPYSSKT RGIEWKRPTE ICADPQFIIG GATRTDICQG ALGDCWLLAA IASLTLNEEI 
       130        140        150        160        170        180 
LARVVPLNQS FQENYAGIFH FQFWQYGEWV EVVVDDRLPT KDGELLFVHS AEGSEFWSAL 
       190        200        210        220        230        240 
LEKAYAKING CYEALSGGAT TEGFEDFTGG IAEWYELKKP PPNLFKIIQK ALQKGSLLGC 
       250        260        270        280        290        300 
SIDITSAADS EAITFQKLVK GHAYSVTGAE EVESNGSLQK LIRIRNPWGE VEWTGRWNDN 
       310        320        330        340        350        360 
CPSWNTIDPE ERERLTRRHE DGEFWMSFSD FLRHYSRLEI CNLTPDTLTS DTYKKWKLTK 
       370        380        390        400        410        420 
MDGNWRRGST AGGCRNYPNT FWMNPQYLIK LEEEDEDEED GESGCTFLVG LIQKHRRRQR 
       430        440        450        460        470        480 
KMGEDMHTIG FGIYEVPEEL SGQTNIHLSK NFFLTNRARE RSDTFINLRE VLNRFKLPPG 
       490        500        510        520        530        540 
EYILVPSTFE PNKDGDFCIR VFSEKKADYQ AVDDEIEANL EEFDISEDDI DDGFRRLFAQ 
       550        560        570        580        590        600 
LAGEDAEISA FELQTILRRV LAKRQDIKSD GFSIETCKIM VDMLDSDGSG KLGLKEFYIL 
       610        620        630        640        650        660 
WTKIQKYQKI YREIDVDRSG TMNSYEMRKA LEEAGFKMPC QLHQVIVARF ADDQLIIDFD 
       670        680        690        700    
NFVRCLVRLE TLFKIFKQLD PENTGTIELD LISWLCFSVL 

Isoforms

- Isoform 2 of Calpain-2 catalytic subunit

Sequence View

        10         20         30         40         50         60 
MAGIAAKLAK DREAAEGLGS HDRAIKYLNQ DYEALRNECL EAGTLFQDPS FPAIPSALGF 
        70         80         90        100        110        120 
KELGPYSSKT RGIEWKRPTE ICADPQFIIG GATRTDICQG ALGDCWLLAA IASLTLNEEI 
       130        140        150        160        170        180 
LARVVPLNQS FQENYAGIFH FQFWQYGEWV EVVVDDRLPT KDGELLFVHS AEGSEFWSAL 
       190        200        210        220        230        240 
LEKAYAKING CYEALSGGAT TEGFEDFTGG IAEWYELKKP PPNLFKIIQK ALQKGSLLGC 
       250        260        270        280        290        300 
SIDITSAADS EAITFQKLVK GHAYSVTGAE EVESNGSLQK LIRIRNPWGE VEWTGRWNDN 
       310        320        330        340        350        360 
CPSWNTIDPE ERERLTRRHE DGEFWMSFSD FLRHYSRLEI CNLTPDTLTS DTYKKWKLTK 
       370        380        390        400        410        420 
MDGNWRRGST AGGCRNYPNT FWMNPQYLIK LEEEDEDEED GESGCTFLVG LIQKHRRRQR 
       430        440        450        460        470        480 
KMGEDMHTIG FGIYEVPEEL SGQTNIHLSK NFFLTNRARE RSDTFINLRE VLNRFKLPPG 
       490        500        510        520        530        540 
EYILVPSTFE PNKDGDFCIR VFSEKKADYQ AVDDEIEANL EEFDISEDDI DDGFRRLFAQ 
       550        560        570        580        590        600 
LAGEDAEISA FELQTILRRV LAKRQDIKSD GFSIETCKIM VDMLDSDGSG KLGLKEFYIL 
       610        620        630        640        650        660 
WTKIQKYQKI YREIDVDRSG TMNSYEMRKA LEEAGFKMPC QLHQVIVARF ADDQLIIDFD 
       670        680        690        700    
NFVRCLVRLE TLFKIFKQLD PENTGTIELD LISWLCFSVL 



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(REFRESH)

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Protein Neighborhood

Domains & Features

6 N-termini - 5 C-termini - 4 Cleavages - 225 Substrates

N-termini

C-termini

Cleavages

Substrates