P25963: NF-kappa-B inhibitor alpha

General Information

Protein names	- NF-kappa-B inhibitor alpha - I-kappa-B-alpha - IkB-alpha - IkappaBalpha - Major histocompatibility complex enhancer-binding protein MAD3
Gene names	NFKBIA
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P25963

3 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MFQAAERPQE WAMEGPRDGL KKERLLDDRH DSGLDSMKDE EYEQMVKELQ EIRLEPQEVP
        70         80         90        100        110        120
RGSEPWKQQL TEDGDSFLHL AIIHEEKALT MEVIRQVKGD LAFLNFQNNL QQTPLHLAVI
       130        140        150        160        170        180
TNQPEIAEAL LGAGCDPELR DFRGNTPLHL ACEQGCLASV GVLTQSCTTP HLHSILKATN
       190        200        210        220        230        240
YNGHTCLHLA SIHGYLGIVE LLVSLGADVN AQEPCNGRTA LHLAVDLQNP DLVSLLLKCG
       250        260        270        280        290        300
ADVNRVTYQG YSPYQLTWGR PSTRIQQQLG QLTLENLQML PESEDEESYD TESEFTEFTE
       310
DELPYDDCVF GGQRLTL

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

3 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P25963-1-unknown	MFQAAE...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P25963-51-unknown	EIRLEP...	51	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1008
P25963-91-unknown	MEVIRQ...	91	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000450514

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VKELQE	50	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1008
...ALTMEV	92	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000451281
...QRLTL	317	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CAN2_HUMAN	50	ELQE.\|.EIRL	inferred from experiment	unknown	MEROPS	Brasier AR	Han Y et al.:Tumor necrosis factor-alpha-ind... (C02.002)	9873017,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)