P35240: Merlin

General Information

Protein names	- Merlin - Moesin-ezrin-radixin-like protein - Neurofibromin-2 - Schwannomerlin - Schwannomin
Gene names	NF2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P35240

3 N-termini

3 C-termini

4 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Merlin - Isoform 3 of Merlin - Isoform 4 of Merlin - Isoform 5 of Merlin - Isoform 6 of Merlin - Isoform 7 of Merlin - Isoform 8 of Merlin - Isoform 9 of Merlin - Isoform 10 of Merlin

Sequence View

        10         20         30         40         50         60
MAGAIASRMS FSSLKRKQPK TFTVRIVTMD AEMEFNCEMK WKGKDLFDLV CRTLGLRETW
        70         80         90        100        110        120
FFGLQYTIKD TVAWLKMDKK VLDHDVSKEE PVTFHFLAKF YPENAEEELV QEITQHLFFL
       130        140        150        160        170        180
QVKKQILDEK IYCPPEASVL LASYAVQAKY GDYDPSVHKR GFLAQEELLP KRVINLYQMT
       190        200        210        220        230        240
PEMWEERITA WYAEHRGRAR DEAEMEYLKI AQDLEMYGVN YFAIRNKKGT ELLLGVDALG
       250        260        270        280        290        300
LHIYDPENRL TPKISFPWNE IRNISYSDKE FTIKPLDKKI DVFKFNSSKL RVNKLILQLC
       310        320        330        340        350        360
IGNHDLFMRR RKADSLEVQQ MKAQAREEKA RKQMERQRLA REKQMREEAE RTRDELERRL
       370        380        390        400        410        420
LQMKEEATMA NEALMRSEET ADLLAEKAQI TEEEAKLLAQ KAAEAEQEMQ RIKATAIRTE
       430        440        450        460        470        480
EEKRLMEQKV LEAEVLALKM AEESERRAKE ADQLKQDLQE AREAERRAKQ KLLEIATKPT
       490        500        510        520        530        540
YPPMNPIPAP LPPDIPSFNL IGDSLSFDFK DTDMKRLSME IEKEKVEYME KSKHLQEQLN
       550        560        570        580        590
ELKTEIEALK LKERETALDI LHNENSDRGG SSKHNTIKKL TLQSAKSRVA FFEEL         10         20         30         40         50         60
MAGAIASRMS FSSLKRKQPK TFTVRIVTMD AEMEFNCEMK WKGKDLFDLV CRTLGLRETW
        70         80         90        100        110        120
FFGLQYTIKD TVAWLKMDKK VLDHDVSKEE PVTFHFLAKF YPENAEEELV QEITQHLFFL
       130        140        150        160        170        180
QVKKQILDEK IYCPPEASVL LASYAVQAKY GDYDPSVHKR GFLAQEELLP KRVINLYQMT
       190        200        210        220        230        240
PEMWEERITA WYAEHRGRAR DEAEMEYLKI AQDLEMYGVN YFAIRNKKGT ELLLGVDALG
       250        260        270        280        290        300
LHIYDPENRL TPKISFPWNE IRNISYSDKE FTIKPLDKKI DVFKFNSSKL RVNKLILQLC
       310        320        330        340        350        360
IGNHDLFMRR RKADSLEVQQ MKAQAREEKA RKQMERQRLA REKQMREEAE RTRDELERRL
       370        380        390        400        410        420
LQMKEEATMA NEALMRSEET ADLLAEKAQI TEEEAKLLAQ KAAEAEQEMQ RIKATAIRTE
       430        440        450        460        470        480
EEKRLMEQKV LEAEVLALKM AEESERRAKE ADQLKQDLQE AREAERRAKQ KLLEIATKPT
       490        500        510        520        530        540
YPPMNPIPAP LPPDIPSFNL IGDSLSFDFK DTDMKRLSME IEKEKVEYME KSKHLQEQLN
       550        560        570        580        590
ELKTEIEALK LKERETALDI LHNENSDRGG SSKHNTIKKL TLQSAKSRVA FFEEL         10         20         30         40         50         60
MAGAIASRMS FSSLKRKQPK TFTVRIVTMD AEMEFNCEMK WKGKDLFDLV CRTLGLRETW
        70         80         90        100        110        120
FFGLQYTIKD TVAWLKMDKK VLDHDVSKEE PVTFHFLAKF YPENAEEELV QEITQHLFFL
       130        140        150        160        170        180
QVKKQILDEK IYCPPEASVL LASYAVQAKY GDYDPSVHKR GFLAQEELLP KRVINLYQMT
       190        200        210        220        230        240
PEMWEERITA WYAEHRGRAR DEAEMEYLKI AQDLEMYGVN YFAIRNKKGT ELLLGVDALG
       250        260        270        280        290        300
LHIYDPENRL TPKISFPWNE IRNISYSDKE FTIKPLDKKI DVFKFNSSKL RVNKLILQLC
       310        320        330        340        350        360
IGNHDLFMRR RKADSLEVQQ MKAQAREEKA RKQMERQRLA REKQMREEAE RTRDELERRL
       370        380        390        400        410        420
LQMKEEATMA NEALMRSEET ADLLAEKAQI TEEEAKLLAQ KAAEAEQEMQ RIKATAIRTE
       430        440        450        460        470        480
EEKRLMEQKV LEAEVLALKM AEESERRAKE ADQLKQDLQE AREAERRAKQ KLLEIATKPT
       490        500        510        520        530        540
YPPMNPIPAP LPPDIPSFNL IGDSLSFDFK DTDMKRLSME IEKEKVEYME KSKHLQEQLN
       550        560        570        580        590
ELKTEIEALK LKERETALDI LHNENSDRGG SSKHNTIKKL TLQSAKSRVA FFEEL         10         20         30         40         50         60
MAGAIASRMS FSSLKRKQPK TFTVRIVTMD AEMEFNCEMK WKGKDLFDLV CRTLGLRETW
        70         80         90        100        110        120
FFGLQYTIKD TVAWLKMDKK VLDHDVSKEE PVTFHFLAKF YPENAEEELV QEITQHLFFL
       130        140        150        160        170        180
QVKKQILDEK IYCPPEASVL LASYAVQAKY GDYDPSVHKR GFLAQEELLP KRVINLYQMT
       190        200        210        220        230        240
PEMWEERITA WYAEHRGRAR DEAEMEYLKI AQDLEMYGVN YFAIRNKKGT ELLLGVDALG
       250        260        270        280        290        300
LHIYDPENRL TPKISFPWNE IRNISYSDKE FTIKPLDKKI DVFKFNSSKL RVNKLILQLC
       310        320        330        340        350        360
IGNHDLFMRR RKADSLEVQQ MKAQAREEKA RKQMERQRLA REKQMREEAE RTRDELERRL
       370        380        390        400        410        420
LQMKEEATMA NEALMRSEET ADLLAEKAQI TEEEAKLLAQ KAAEAEQEMQ RIKATAIRTE
       430        440        450        460        470        480
EEKRLMEQKV LEAEVLALKM AEESERRAKE ADQLKQDLQE AREAERRAKQ KLLEIATKPT
       490        500        510        520        530        540
YPPMNPIPAP LPPDIPSFNL IGDSLSFDFK DTDMKRLSME IEKEKVEYME KSKHLQEQLN
       550        560        570        580        590
ELKTEIEALK LKERETALDI LHNENSDRGG SSKHNTIKKL TLQSAKSRVA FFEEL         10         20         30         40         50         60
MAGAIASRMS FSSLKRKQPK TFTVRIVTMD AEMEFNCEMK WKGKDLFDLV CRTLGLRETW
        70         80         90        100        110        120
FFGLQYTIKD TVAWLKMDKK VLDHDVSKEE PVTFHFLAKF YPENAEEELV QEITQHLFFL
       130        140        150        160        170        180
QVKKQILDEK IYCPPEASVL LASYAVQAKY GDYDPSVHKR GFLAQEELLP KRVINLYQMT
       190        200        210        220        230        240
PEMWEERITA WYAEHRGRAR DEAEMEYLKI AQDLEMYGVN YFAIRNKKGT ELLLGVDALG
       250        260        270        280        290        300
LHIYDPENRL TPKISFPWNE IRNISYSDKE FTIKPLDKKI DVFKFNSSKL RVNKLILQLC
       310        320        330        340        350        360
IGNHDLFMRR RKADSLEVQQ MKAQAREEKA RKQMERQRLA REKQMREEAE RTRDELERRL
       370        380        390        400        410        420
LQMKEEATMA NEALMRSEET ADLLAEKAQI TEEEAKLLAQ KAAEAEQEMQ RIKATAIRTE
       430        440        450        460        470        480
EEKRLMEQKV LEAEVLALKM AEESERRAKE ADQLKQDLQE AREAERRAKQ KLLEIATKPT
       490        500        510        520        530        540
YPPMNPIPAP LPPDIPSFNL IGDSLSFDFK DTDMKRLSME IEKEKVEYME KSKHLQEQLN
       550        560        570        580        590
ELKTEIEALK LKERETALDI LHNENSDRGG SSKHNTIKKL TLQSAKSRVA FFEEL         10         20         30         40         50         60
MAGAIASRMS FSSLKRKQPK TFTVRIVTMD AEMEFNCEMK WKGKDLFDLV CRTLGLRETW
        70         80         90        100        110        120
FFGLQYTIKD TVAWLKMDKK VLDHDVSKEE PVTFHFLAKF YPENAEEELV QEITQHLFFL
       130        140        150        160        170        180
QVKKQILDEK IYCPPEASVL LASYAVQAKY GDYDPSVHKR GFLAQEELLP KRVINLYQMT
       190        200        210        220        230        240
PEMWEERITA WYAEHRGRAR DEAEMEYLKI AQDLEMYGVN YFAIRNKKGT ELLLGVDALG
       250        260        270        280        290        300
LHIYDPENRL TPKISFPWNE IRNISYSDKE FTIKPLDKKI DVFKFNSSKL RVNKLILQLC
       310        320        330        340        350        360
IGNHDLFMRR RKADSLEVQQ MKAQAREEKA RKQMERQRLA REKQMREEAE RTRDELERRL
       370        380        390        400        410        420
LQMKEEATMA NEALMRSEET ADLLAEKAQI TEEEAKLLAQ KAAEAEQEMQ RIKATAIRTE
       430        440        450        460        470        480
EEKRLMEQKV LEAEVLALKM AEESERRAKE ADQLKQDLQE AREAERRAKQ KLLEIATKPT
       490        500        510        520        530        540
YPPMNPIPAP LPPDIPSFNL IGDSLSFDFK DTDMKRLSME IEKEKVEYME KSKHLQEQLN
       550        560        570        580        590
ELKTEIEALK LKERETALDI LHNENSDRGG SSKHNTIKKL TLQSAKSRVA FFEEL         10         20         30         40         50         60
MAGAIASRMS FSSLKRKQPK TFTVRIVTMD AEMEFNCEMK WKGKDLFDLV CRTLGLRETW
        70         80         90        100        110        120
FFGLQYTIKD TVAWLKMDKK VLDHDVSKEE PVTFHFLAKF YPENAEEELV QEITQHLFFL
       130        140        150        160        170        180
QVKKQILDEK IYCPPEASVL LASYAVQAKY GDYDPSVHKR GFLAQEELLP KRVINLYQMT
       190        200        210        220        230        240
PEMWEERITA WYAEHRGRAR DEAEMEYLKI AQDLEMYGVN YFAIRNKKGT ELLLGVDALG
       250        260        270        280        290        300
LHIYDPENRL TPKISFPWNE IRNISYSDKE FTIKPLDKKI DVFKFNSSKL RVNKLILQLC
       310        320        330        340        350        360
IGNHDLFMRR RKADSLEVQQ MKAQAREEKA RKQMERQRLA REKQMREEAE RTRDELERRL
       370        380        390        400        410        420
LQMKEEATMA NEALMRSEET ADLLAEKAQI TEEEAKLLAQ KAAEAEQEMQ RIKATAIRTE
       430        440        450        460        470        480
EEKRLMEQKV LEAEVLALKM AEESERRAKE ADQLKQDLQE AREAERRAKQ KLLEIATKPT
       490        500        510        520        530        540
YPPMNPIPAP LPPDIPSFNL IGDSLSFDFK DTDMKRLSME IEKEKVEYME KSKHLQEQLN
       550        560        570        580        590
ELKTEIEALK LKERETALDI LHNENSDRGG SSKHNTIKKL TLQSAKSRVA FFEEL         10         20         30         40         50         60
MAGAIASRMS FSSLKRKQPK TFTVRIVTMD AEMEFNCEMK WKGKDLFDLV CRTLGLRETW
        70         80         90        100        110        120
FFGLQYTIKD TVAWLKMDKK VLDHDVSKEE PVTFHFLAKF YPENAEEELV QEITQHLFFL
       130        140        150        160        170        180
QVKKQILDEK IYCPPEASVL LASYAVQAKY GDYDPSVHKR GFLAQEELLP KRVINLYQMT
       190        200        210        220        230        240
PEMWEERITA WYAEHRGRAR DEAEMEYLKI AQDLEMYGVN YFAIRNKKGT ELLLGVDALG
       250        260        270        280        290        300
LHIYDPENRL TPKISFPWNE IRNISYSDKE FTIKPLDKKI DVFKFNSSKL RVNKLILQLC
       310        320        330        340        350        360
IGNHDLFMRR RKADSLEVQQ MKAQAREEKA RKQMERQRLA REKQMREEAE RTRDELERRL
       370        380        390        400        410        420
LQMKEEATMA NEALMRSEET ADLLAEKAQI TEEEAKLLAQ KAAEAEQEMQ RIKATAIRTE
       430        440        450        460        470        480
EEKRLMEQKV LEAEVLALKM AEESERRAKE ADQLKQDLQE AREAERRAKQ KLLEIATKPT
       490        500        510        520        530        540
YPPMNPIPAP LPPDIPSFNL IGDSLSFDFK DTDMKRLSME IEKEKVEYME KSKHLQEQLN
       550        560        570        580        590
ELKTEIEALK LKERETALDI LHNENSDRGG SSKHNTIKKL TLQSAKSRVA FFEEL         10         20         30         40         50         60
MAGAIASRMS FSSLKRKQPK TFTVRIVTMD AEMEFNCEMK WKGKDLFDLV CRTLGLRETW
        70         80         90        100        110        120
FFGLQYTIKD TVAWLKMDKK VLDHDVSKEE PVTFHFLAKF YPENAEEELV QEITQHLFFL
       130        140        150        160        170        180
QVKKQILDEK IYCPPEASVL LASYAVQAKY GDYDPSVHKR GFLAQEELLP KRVINLYQMT
       190        200        210        220        230        240
PEMWEERITA WYAEHRGRAR DEAEMEYLKI AQDLEMYGVN YFAIRNKKGT ELLLGVDALG
       250        260        270        280        290        300
LHIYDPENRL TPKISFPWNE IRNISYSDKE FTIKPLDKKI DVFKFNSSKL RVNKLILQLC
       310        320        330        340        350        360
IGNHDLFMRR RKADSLEVQQ MKAQAREEKA RKQMERQRLA REKQMREEAE RTRDELERRL
       370        380        390        400        410        420
LQMKEEATMA NEALMRSEET ADLLAEKAQI TEEEAKLLAQ KAAEAEQEMQ RIKATAIRTE
       430        440        450        460        470        480
EEKRLMEQKV LEAEVLALKM AEESERRAKE ADQLKQDLQE AREAERRAKQ KLLEIATKPT
       490        500        510        520        530        540
YPPMNPIPAP LPPDIPSFNL IGDSLSFDFK DTDMKRLSME IEKEKVEYME KSKHLQEQLN
       550        560        570        580        590
ELKTEIEALK LKERETALDI LHNENSDRGG SSKHNTIKKL TLQSAKSRVA FFEEL

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 3 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P35240-1-unknown	MAGAIA...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P35240-1-unknown	MAGAIA...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt80900
P35240-1-unknown	MAGAIA...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt80901
P35240-1-unknown	MAGAIA...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt80902
P35240-1-unknown	MAGAIA...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt80903
P35240-1-unknown	MAGAIA...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt80904
P35240-1-unknown	MAGAIA...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt80905
P35240-1-unknown	MAGAIA...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt80906
P35240-1-unknown	MAGAIA...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt80907
P35240-295-unknown	LILQLC...	295	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC751
P35240-295-unknown	LILQLC...	295	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1014
P35240-295-unknown	LILQLC...	295	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt147079
P35240-295-unknown	LILQLC...	295	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt148566
P35240-295-unknown	LILQLC...	295	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt148616
P35240-295-unknown	LILQLC...	295	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt149754
P35240-295-unknown	LILQLC...	295	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt149755
P35240-295-unknown	LILQLC...	295	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt149756
P35240-299-unknown	LCIGNH...	299	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC759
P35240-299-unknown	LCIGNH...	299	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1022
P35240-299-unknown	LCIGNH...	299	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt147190
P35240-299-unknown	LCIGNH...	299	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt148696
P35240-299-unknown	LCIGNH...	299	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt148728
P35240-299-unknown	LCIGNH...	299	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt149825
P35240-299-unknown	LCIGNH...	299	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt149826
P35240-299-unknown	LCIGNH...	299	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt149827

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LRVNKL	294	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC751
...LRVNKL	294	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1014
...LRVNKL	294	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130412
...LRVNKL	294	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131940
...LRVNKL	294	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131990
...LRVNKL	294	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133143
...LRVNKL	294	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133144
...LRVNKL	294	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133145
...KLILQL	298	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC759
...KLILQL	298	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1022
...KLILQL	298	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130530
...KLILQL	298	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132071
...KLILQL	298	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132104
...KLILQL	298	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133216
...KLILQL	298	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133217
...KLILQL	298	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133218
...FFEEL	595	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CAN1_HUMAN	294	VNKL.\|.LILQ	inferred from experiment	unknown	MEROPS	Nakao M	Kimura Y et al.:The involvement of calpain-depe... (C02.001)	9701243,
CAN2_HUMAN	294	VNKL.\|.LILQ	inferred from experiment	unknown	MEROPS	Nakao M	Kimura Y et al.:The involvement of calpain-depe... (C02.001)	9701243,
CAN1_HUMAN	298	ILQL.\|.LCIG	inferred from experiment	unknown	MEROPS	Nakao M	Kimura Y et al.:The involvement of calpain-depe... (C02.001)	9701243,
CAN2_HUMAN	298	ILQL.\|.LCIG	inferred from experiment	unknown	MEROPS	Nakao M	Kimura Y et al.:The involvement of calpain-depe... (C02.001)	9701243,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)