TopFIND 4.0

P55211: Caspase-9

General Information

Protein names
- Caspase-9
- CASP-9
- 3.4.22.62 {ECO:0000269|PubMed:23516580}
- Apoptotic protease Mch-6
- Apoptotic protease-activating factor 3
- APAF-3
- ICE-like apoptotic protease 6
- ICE-LAP6
- Caspase-9 subunit p35
- Caspase-9 subunit p10
Gene names CASP9
Organism Homo sapiens
Protease Family C14.010
Protease ID C14.010
Chromosome location
UniProt ID P55211

9

N-termini

8

C-termini

13

Cleavages

22

Substrates

Sequence

        10         20         30         40         50         60 
MDEADRRLLR RCRLRLVEEL QVDQLWDALL SRELFRPHMI EDIQRAGSGS RRDQARQLII 
        70         80         90        100        110        120 
DLETRGSQAL PLFISCLEDT GQDMLASFLR TNRQAAKLSK PTLENLTPVV LRPEIRKPEV 
       130        140        150        160        170        180 
LRPETPRPVD IGSGGFGDVG ALESLRGNAD LAYILSMEPC GHCLIINNVN FCRESGLRTR 
       190        200        210        220        230        240 
TGSNIDCEKL RRRFSSLHFM VEVKGDLTAK KMVLALLELA QQDHGALDCC VVVILSHGCQ 
       250        260        270        280        290        300 
ASHLQFPGAV YGTDGCPVSV EKIVNIFNGT SCPSLGGKPK LFFIQACGGE QKDHGFEVAS 
       310        320        330        340        350        360 
TSPEDESPGS NPEPDATPFQ EGLRTFDQLD AISSLPTPSD IFVSYSTFPG FVSWRDPKSG 
       370        380        390        400        410    
SWYVETLDDI FEQWAHSEDL QSLLLRVANA VSVKGIYKQM PGCFNFLRKK LFFKTS

Isoforms

- Isoform 2 of Caspase-9 - Isoform 3 of Caspase-9 - Isoform 4 of Caspase-9

Sequence View

        10         20         30         40         50         60 
MDEADRRLLR RCRLRLVEEL QVDQLWDALL SRELFRPHMI EDIQRAGSGS RRDQARQLII 
        70         80         90        100        110        120 
DLETRGSQAL PLFISCLEDT GQDMLASFLR TNRQAAKLSK PTLENLTPVV LRPEIRKPEV 
       130        140        150        160        170        180 
LRPETPRPVD IGSGGFGDVG ALESLRGNAD LAYILSMEPC GHCLIINNVN FCRESGLRTR 
       190        200        210        220        230        240 
TGSNIDCEKL RRRFSSLHFM VEVKGDLTAK KMVLALLELA QQDHGALDCC VVVILSHGCQ 
       250        260        270        280        290        300 
ASHLQFPGAV YGTDGCPVSV EKIVNIFNGT SCPSLGGKPK LFFIQACGGE QKDHGFEVAS 
       310        320        330        340        350        360 
TSPEDESPGS NPEPDATPFQ EGLRTFDQLD AISSLPTPSD IFVSYSTFPG FVSWRDPKSG 
       370        380        390        400        410    
SWYVETLDDI FEQWAHSEDL QSLLLRVANA VSVKGIYKQM PGCFNFLRKK LFFKTS         10         20         30         40         50         60 
MDEADRRLLR RCRLRLVEEL QVDQLWDALL SRELFRPHMI EDIQRAGSGS RRDQARQLII 
        70         80         90        100        110        120 
DLETRGSQAL PLFISCLEDT GQDMLASFLR TNRQAAKLSK PTLENLTPVV LRPEIRKPEV 
       130        140        150        160        170        180 
LRPETPRPVD IGSGGFGDVG ALESLRGNAD LAYILSMEPC GHCLIINNVN FCRESGLRTR 
       190        200        210        220        230        240 
TGSNIDCEKL RRRFSSLHFM VEVKGDLTAK KMVLALLELA QQDHGALDCC VVVILSHGCQ 
       250        260        270        280        290        300 
ASHLQFPGAV YGTDGCPVSV EKIVNIFNGT SCPSLGGKPK LFFIQACGGE QKDHGFEVAS 
       310        320        330        340        350        360 
TSPEDESPGS NPEPDATPFQ EGLRTFDQLD AISSLPTPSD IFVSYSTFPG FVSWRDPKSG 
       370        380        390        400        410    
SWYVETLDDI FEQWAHSEDL QSLLLRVANA VSVKGIYKQM PGCFNFLRKK LFFKTS         10         20         30         40         50         60 
MDEADRRLLR RCRLRLVEEL QVDQLWDALL SRELFRPHMI EDIQRAGSGS RRDQARQLII 
        70         80         90        100        110        120 
DLETRGSQAL PLFISCLEDT GQDMLASFLR TNRQAAKLSK PTLENLTPVV LRPEIRKPEV 
       130        140        150        160        170        180 
LRPETPRPVD IGSGGFGDVG ALESLRGNAD LAYILSMEPC GHCLIINNVN FCRESGLRTR 
       190        200        210        220        230        240 
TGSNIDCEKL RRRFSSLHFM VEVKGDLTAK KMVLALLELA QQDHGALDCC VVVILSHGCQ 
       250        260        270        280        290        300 
ASHLQFPGAV YGTDGCPVSV EKIVNIFNGT SCPSLGGKPK LFFIQACGGE QKDHGFEVAS 
       310        320        330        340        350        360 
TSPEDESPGS NPEPDATPFQ EGLRTFDQLD AISSLPTPSD IFVSYSTFPG FVSWRDPKSG 
       370        380        390        400        410    
SWYVETLDDI FEQWAHSEDL QSLLLRVANA VSVKGIYKQM PGCFNFLRKK LFFKTS



Filter Information:


(REFRESH)

Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


Perturbation of System:


Biological System:


Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

9 N-termini - 8 C-termini - 13 Cleavages - 22 Substrates

N-termini

C-termini

Cleavages

Substrates