O95671: Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein {ECO:0000305}
Protein names | - Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein {ECO:0000305} - dTTP/UTP pyrophosphatase {ECO:0000305} - dTTPase/UTPase {ECO:0000305} - 3.6.1.9 {ECO:0000269|PubMed:24210219} - Nucleoside triphosphate pyrophosphatase {ECO:0000303|PubMed:24210219} - Nucleotide pyrophosphatase {ECO:0000303|PubMed:24210219} - Nucleotide PPase {ECO:0000305} - N-acetylserotonin O-methyltransferase-like protein - ASMTL - 2.1.1.- |
---|---|
Gene names | ASMTL |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | O95671 |
7
N-termini
4
C-termini
3
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MVLCPVIGKL LHKRVVLASA SPRRQEILSN AGLRFEVVPS KFKEKLDKAS FATPYGYAME
70 80 90 100 110 120
TAKQKALEVA NRLYQKDLRA PDVVIGADTI VTVGGLILEK PVDKQDAYRM LSRLSGREHS
130 140 150 160 170 180
VFTGVAIVHC SSKDHQLDTR VSEFYEETKV KFSELSEELL WEYVHSGEPM DKAGGYGIQA
190 200 210 220 230 240
LGGMLVESVH GDFLNVVGFP LNHFCKQLVK LYYPPRPEDL RRSVKHDSIP AADTFEDLSD
250 260 270 280 290 300
VEGGGSEPTQ RDAGSRDEKA EAGEAGQATA EAECHRTRET LPPFPTRLLE LIEGFMLSKG
310 320 330 340 350 360
LLTACKLKVF DLLKDEAPQK AADIASKVDA SACGMERLLD ICAAMGLLEK TEQGYSNTET
370 380 390 400 410 420
ANVYLASDGE YSLHGFIMHN NDLTWNLFTY LEFAIREGTN QHHRALGKKA EDLFQDAYYQ
430 440 450 460 470 480
SPETRLRFMR AMHGMTKLTA CQVATAFNLS RFSSACDVGG CTGALARELA REYPRMQVTV
490 500 510 520 530 540
FDLPDIIELA AHFQPPGPQA VQIHFAAGDF FRDPLPSAEL YVLCRILHDW PDDKVHKLLS
550 560 570 580 590 600
RVAESCKPGA GLLLVETLLD EEKRVAQRAL MQSLNMLVQT EGKERSLGEY QCLLELHGFH
610 620
QVQVVHLGGV LDAILATKVA P
Isoforms
- Isoform 2 of N-acetylserotonin O-methyltransferase-like protein - Isoform 3 of N-acetylserotonin O-methyltransferase-like protein - Isoform 2 of Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein - Isoform 3 of Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase proteinSequence View
10 20 30 40 50 60
MVLCPVIGKL LHKRVVLASA SPRRQEILSN AGLRFEVVPS KFKEKLDKAS FATPYGYAME
70 80 90 100 110 120
TAKQKALEVA NRLYQKDLRA PDVVIGADTI VTVGGLILEK PVDKQDAYRM LSRLSGREHS
130 140 150 160 170 180
VFTGVAIVHC SSKDHQLDTR VSEFYEETKV KFSELSEELL WEYVHSGEPM DKAGGYGIQA
190 200 210 220 230 240
LGGMLVESVH GDFLNVVGFP LNHFCKQLVK LYYPPRPEDL RRSVKHDSIP AADTFEDLSD
250 260 270 280 290 300
VEGGGSEPTQ RDAGSRDEKA EAGEAGQATA EAECHRTRET LPPFPTRLLE LIEGFMLSKG
310 320 330 340 350 360
LLTACKLKVF DLLKDEAPQK AADIASKVDA SACGMERLLD ICAAMGLLEK TEQGYSNTET
370 380 390 400 410 420
ANVYLASDGE YSLHGFIMHN NDLTWNLFTY LEFAIREGTN QHHRALGKKA EDLFQDAYYQ
430 440 450 460 470 480
SPETRLRFMR AMHGMTKLTA CQVATAFNLS RFSSACDVGG CTGALARELA REYPRMQVTV
490 500 510 520 530 540
FDLPDIIELA AHFQPPGPQA VQIHFAAGDF FRDPLPSAEL YVLCRILHDW PDDKVHKLLS
550 560 570 580 590 600
RVAESCKPGA GLLLVETLLD EEKRVAQRAL MQSLNMLVQT EGKERSLGEY QCLLELHGFH
610 620
QVQVVHLGGV LDAILATKVA P
10 20 30 40 50 60
MVLCPVIGKL LHKRVVLASA SPRRQEILSN AGLRFEVVPS KFKEKLDKAS FATPYGYAME
70 80 90 100 110 120
TAKQKALEVA NRLYQKDLRA PDVVIGADTI VTVGGLILEK PVDKQDAYRM LSRLSGREHS
130 140 150 160 170 180
VFTGVAIVHC SSKDHQLDTR VSEFYEETKV KFSELSEELL WEYVHSGEPM DKAGGYGIQA
190 200 210 220 230 240
LGGMLVESVH GDFLNVVGFP LNHFCKQLVK LYYPPRPEDL RRSVKHDSIP AADTFEDLSD
250 260 270 280 290 300
VEGGGSEPTQ RDAGSRDEKA EAGEAGQATA EAECHRTRET LPPFPTRLLE LIEGFMLSKG
310 320 330 340 350 360
LLTACKLKVF DLLKDEAPQK AADIASKVDA SACGMERLLD ICAAMGLLEK TEQGYSNTET
370 380 390 400 410 420
ANVYLASDGE YSLHGFIMHN NDLTWNLFTY LEFAIREGTN QHHRALGKKA EDLFQDAYYQ
430 440 450 460 470 480
SPETRLRFMR AMHGMTKLTA CQVATAFNLS RFSSACDVGG CTGALARELA REYPRMQVTV
490 500 510 520 530 540
FDLPDIIELA AHFQPPGPQA VQIHFAAGDF FRDPLPSAEL YVLCRILHDW PDDKVHKLLS
550 560 570 580 590 600
RVAESCKPGA GLLLVETLLD EEKRVAQRAL MQSLNMLVQT EGKERSLGEY QCLLELHGFH
610 620
QVQVVHLGGV LDAILATKVA P
10 20 30 40 50 60
MVLCPVIGKL LHKRVVLASA SPRRQEILSN AGLRFEVVPS KFKEKLDKAS FATPYGYAME
70 80 90 100 110 120
TAKQKALEVA NRLYQKDLRA PDVVIGADTI VTVGGLILEK PVDKQDAYRM LSRLSGREHS
130 140 150 160 170 180
VFTGVAIVHC SSKDHQLDTR VSEFYEETKV KFSELSEELL WEYVHSGEPM DKAGGYGIQA
190 200 210 220 230 240
LGGMLVESVH GDFLNVVGFP LNHFCKQLVK LYYPPRPEDL RRSVKHDSIP AADTFEDLSD
250 260 270 280 290 300
VEGGGSEPTQ RDAGSRDEKA EAGEAGQATA EAECHRTRET LPPFPTRLLE LIEGFMLSKG
310 320 330 340 350 360
LLTACKLKVF DLLKDEAPQK AADIASKVDA SACGMERLLD ICAAMGLLEK TEQGYSNTET
370 380 390 400 410 420
ANVYLASDGE YSLHGFIMHN NDLTWNLFTY LEFAIREGTN QHHRALGKKA EDLFQDAYYQ
430 440 450 460 470 480
SPETRLRFMR AMHGMTKLTA CQVATAFNLS RFSSACDVGG CTGALARELA REYPRMQVTV
490 500 510 520 530 540
FDLPDIIELA AHFQPPGPQA VQIHFAAGDF FRDPLPSAEL YVLCRILHDW PDDKVHKLLS
550 560 570 580 590 600
RVAESCKPGA GLLLVETLLD EEKRVAQRAL MQSLNMLVQT EGKERSLGEY QCLLELHGFH
610 620
QVQVVHLGGV LDAILATKVA P
10 20 30 40 50 60
MVLCPVIGKL LHKRVVLASA SPRRQEILSN AGLRFEVVPS KFKEKLDKAS FATPYGYAME
70 80 90 100 110 120
TAKQKALEVA NRLYQKDLRA PDVVIGADTI VTVGGLILEK PVDKQDAYRM LSRLSGREHS
130 140 150 160 170 180
VFTGVAIVHC SSKDHQLDTR VSEFYEETKV KFSELSEELL WEYVHSGEPM DKAGGYGIQA
190 200 210 220 230 240
LGGMLVESVH GDFLNVVGFP LNHFCKQLVK LYYPPRPEDL RRSVKHDSIP AADTFEDLSD
250 260 270 280 290 300
VEGGGSEPTQ RDAGSRDEKA EAGEAGQATA EAECHRTRET LPPFPTRLLE LIEGFMLSKG
310 320 330 340 350 360
LLTACKLKVF DLLKDEAPQK AADIASKVDA SACGMERLLD ICAAMGLLEK TEQGYSNTET
370 380 390 400 410 420
ANVYLASDGE YSLHGFIMHN NDLTWNLFTY LEFAIREGTN QHHRALGKKA EDLFQDAYYQ
430 440 450 460 470 480
SPETRLRFMR AMHGMTKLTA CQVATAFNLS RFSSACDVGG CTGALARELA REYPRMQVTV
490 500 510 520 530 540
FDLPDIIELA AHFQPPGPQA VQIHFAAGDF FRDPLPSAEL YVLCRILHDW PDDKVHKLLS
550 560 570 580 590 600
RVAESCKPGA GLLLVETLLD EEKRVAQRAL MQSLNMLVQT EGKERSLGEY QCLLELHGFH
610 620
QVQVVHLGGV LDAILATKVA P
Protein Neighborhood
Domains & Features
7 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
O95671-1-unknown | MVLCPV... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
O95671-1-unknown | MVLCPV... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt67652 | |||
O95671-59-unknown | METAKQ... | 59 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt67653 | |||
O95671-228- | SIPAAD... | 228 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
O95671-228-unknown | SIPAAD... | 228 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt174118 | |||
O95671-228-unknown | SIPAAD... | 228 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt174119 | |||
O95671-234-unknown | TFEDLS... | 234 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11025 | |||
O95671-234-unknown | TFEDLS... | 234 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt145721 | |||
O95671-234-unknown | TFEDLS... | 234 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt147256 | |||
O95671-237-unknown | DLSDVE... | 237 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC3176 | |||
O95671-237-unknown | DLSDVE... | 237 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt145857 | |||
O95671-237-unknown | DLSDVE... | 237 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt147384 | |||
O95671-241-unknown | VEGGGS... | 241 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC3179 | |||
O95671-241-unknown | VEGGGS... | 241 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt146002 | |||
O95671-241-unknown | VEGGGS... | 241 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt147548 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...IPAADT | 233 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11025 | |||
...IPAADT | 233 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt129018 | |||
...IPAADT | 233 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt130599 | |||
...ADTFED | 236 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC3176 | |||
...ADTFED | 236 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt129155 | |||
...ADTFED | 236 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt130731 | |||
...EDLSDV | 240 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC3179 | |||
...EDLSDV | 240 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt129301 | |||
...EDLSDV | 240 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt130899 | |||
...TKVAP | 621 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...TKVAP | 621 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt63271 | |||
...TKVAP | 621 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt63270 |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
GRAB_HUMAN | 233 | AADT.|.TFED | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Complementary positional proteo... (M14.017) | 20526345, |
CASP9_HUMAN | 236 | TFED.|.DLSD | inferred from experiment | unknown | MEROPS | Jimenez CR | Checinska A et al.:Comparative proteomics analysis... (C14.010) | 19118655, |
CASP9_HUMAN | 240 | LSDV.|.VEGG | inferred from experiment | unknown | MEROPS | Jimenez CR | Checinska A et al.:Comparative proteomics analysis... (C14.010) | 19118655, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|