P15976: Erythroid transcription factor

General Information

Protein names	- Erythroid transcription factor - Eryf1 - GATA-binding factor 1 - GATA-1 - GF-1 - NF-E1 DNA-binding protein
Gene names	GATA1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P15976

4 N-termini

2 C-termini

5 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Erythroid transcription factor - Isoform 3 of Erythroid transcription factor

Sequence View

        10         20         30         40         50         60
MEFPGLGSLG TSEPLPQFVD PALVSSTPES GVFFPSGPEG LDAAASSTAP STATAAAAAL
        70         80         90        100        110        120
AYYRDAEAYR HSPVFQVYPL LNCMEGIPGG SPYAGWAYGK TGLYPASTVC PTREDSPPQA
       130        140        150        160        170        180
VEDLDGKGST SFLETLKTER LSPDLLTLGP ALPSSLPVPN SAYGGPDFSS TFFSPTGSPL
       190        200        210        220        230        240
NSAAYSSPKL RGTLPLPPCE ARECVNCGAT ATPLWRRDRT GHYLCNACGL YHKMNGQNRP
       250        260        270        280        290        300
LIRPKKRLIV SKRAGTQCTN CQTTTTTLWR RNASGDPVCN ACGLYYKLHQ VNRPLTMRKD
       310        320        330        340        350        360
GIQTRNRKAS GKGKKKRGSS LGGTGAAEGP AGGFMVVAGG SGSGNCGEVA SGLTLGPPGT
       370        380        390        400        410
AHLYQGLGPV VLSGPVSHLM PFPGPLLGSP TGSFPTGPMP PTTSTTVVAP LSS         10         20         30         40         50         60
MEFPGLGSLG TSEPLPQFVD PALVSSTPES GVFFPSGPEG LDAAASSTAP STATAAAAAL
        70         80         90        100        110        120
AYYRDAEAYR HSPVFQVYPL LNCMEGIPGG SPYAGWAYGK TGLYPASTVC PTREDSPPQA
       130        140        150        160        170        180
VEDLDGKGST SFLETLKTER LSPDLLTLGP ALPSSLPVPN SAYGGPDFSS TFFSPTGSPL
       190        200        210        220        230        240
NSAAYSSPKL RGTLPLPPCE ARECVNCGAT ATPLWRRDRT GHYLCNACGL YHKMNGQNRP
       250        260        270        280        290        300
LIRPKKRLIV SKRAGTQCTN CQTTTTTLWR RNASGDPVCN ACGLYYKLHQ VNRPLTMRKD
       310        320        330        340        350        360
GIQTRNRKAS GKGKKKRGSS LGGTGAAEGP AGGFMVVAGG SGSGNCGEVA SGLTLGPPGT
       370        380        390        400        410
AHLYQGLGPV VLSGPVSHLM PFPGPLLGSP TGSFPTGPMP PTTSTTVVAP LSS

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P15976-1-unknown	MEFPGL...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P15976-1-unknown	MEFPGL...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt75736
P15976-84-unknown	MEGIPG...	84	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt75737
P15976-84-unknown	MEGIPG...	84	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt107999
P15976-126-	GKGSTS...	126		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P15976-126-unknown	GKGSTS...	126	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3185
P15976-126-unknown	GKGSTS...	126	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1663
P15976-126-unknown	GKGSTS...	126	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3199
P15976-126-unknown	GKGSTS...	126	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3054
P15976-126-unknown	GKGSTS...	126	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2814
P15976-126-unknown	GKGSTS...	126	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt138598
P15976-126-unknown	GKGSTS...	126	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143716

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VEDLDG	125	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3185
...VEDLDG	125	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1663
...VEDLDG	125	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3199
...VEDLDG	125	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3054
...VEDLDG	125	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2814
...VEDLDG	125	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121649
...VEDLDG	125	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126959
...APLSS	413	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...APLSS	413	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt71355

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP9_HUMAN	125	DLDG.\|.GKGS	inferred from experiment	unknown	MEROPS	Peschle C	De Maria R et al.:Negative regulation of erythrop... (C14.003)	10519553,
CASP3_HUMAN	125	DLDG.\|.GKGS	inferred from experiment	unknown	MEROPS	Peschle C	De Maria R et al.:Negative regulation of erythrop... (C14.003)	10519553,
CASPA_HUMAN	125	DLDG.\|.GKGS	inferred from experiment	unknown	MEROPS	Peschle C	De Maria R et al.:Negative regulation of erythrop... (C14.003)	10519553,
CASP8_HUMAN	125	DLDG.\|.GKGS	inferred from experiment	unknown	MEROPS	Peschle C	De Maria R et al.:Negative regulation of erythrop... (C14.003)	10519553,
CASP7_HUMAN	125	DLDG.\|.GKGS	inferred from experiment	unknown	MEROPS	Peschle C	De Maria R et al.:Negative regulation of erythrop... (C14.003)	10519553,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)