Q92851: Caspase-10
Protein names | - Caspase-10 - CASP-10 - 3.4.22.63 - Apoptotic protease Mch-4 - FAS-associated death domain protein interleukin-1B-converting enzyme 2 - FLICE2 - ICE-like apoptotic protease 4 - Caspase-10 subunit p23/17 - Caspase-10 subunit p12 |
---|---|
Gene names | CASP10 |
Organism | Homo sapiens |
Protease Family | C14.011 |
Protease ID | C14.011 |
Chromosome location | |
UniProt ID | Q92851 |
5
N-termini
3
C-termini
3
Cleavages
16
Substrates
Sequence
10 20 30 40 50 60
MKSQGQHWYS SSDKNCKVSF REKLLIIDSN LGVQDVENLK FLCIGLVPNK KLEKSSSASD
70 80 90 100 110 120
VFEHLLAEDL LSEEDPFFLA ELLYIIRQKK LLQHLNCTKE EVERLLPTRQ RVSLFRNLLY
130 140 150 160 170 180
ELSEGIDSEN LKDMIFLLKD SLPKTEMTSL SFLAFLEKQG KIDEDNLTCL EDLCKTVVPK
190 200 210 220 230 240
LLRNIEKYKR EKAIQIVTPP VDKEAESYQG EEELVSQTDV KTFLEALPQE SWQNKHAGSN
250 260 270 280 290 300
GNRATNGAPS LVSRGMQGAS ANTLNSETST KRAAVYRMNR NHRGLCVIVN NHSFTSLKDR
310 320 330 340 350 360
QGTHKDAEIL SHVFQWLGFT VHIHNNVTKV EMEMVLQKQK CNPAHADGDC FVFCILTHGR
370 380 390 400 410 420
FGAVYSSDEA LIPIREIMSH FTALQCPRLA EKPKLFFIQA CQGEEIQPSV SIEADALNPE
430 440 450 460 470 480
QAPTSLQDSI PAEADFLLGL ATVPGYVSFR HVEEGSWYIQ SLCNHLKKLV PRMLKFLEKT
490 500 510 520
MEIRGRKRTV WGAKQISATS LPTAISAQTP RPPMRRWSSV S
Isoforms
- Isoform B of Caspase-10 - Isoform D of Caspase-10 - Isoform C of Caspase-10 - Isoform 5 of Caspase-10 - Isoform 6 of Caspase-10 - Isoform 7 of Caspase-10Sequence View
10 20 30 40 50 60
MKSQGQHWYS SSDKNCKVSF REKLLIIDSN LGVQDVENLK FLCIGLVPNK KLEKSSSASD
70 80 90 100 110 120
VFEHLLAEDL LSEEDPFFLA ELLYIIRQKK LLQHLNCTKE EVERLLPTRQ RVSLFRNLLY
130 140 150 160 170 180
ELSEGIDSEN LKDMIFLLKD SLPKTEMTSL SFLAFLEKQG KIDEDNLTCL EDLCKTVVPK
190 200 210 220 230 240
LLRNIEKYKR EKAIQIVTPP VDKEAESYQG EEELVSQTDV KTFLEALPQE SWQNKHAGSN
250 260 270 280 290 300
GNRATNGAPS LVSRGMQGAS ANTLNSETST KRAAVYRMNR NHRGLCVIVN NHSFTSLKDR
310 320 330 340 350 360
QGTHKDAEIL SHVFQWLGFT VHIHNNVTKV EMEMVLQKQK CNPAHADGDC FVFCILTHGR
370 380 390 400 410 420
FGAVYSSDEA LIPIREIMSH FTALQCPRLA EKPKLFFIQA CQGEEIQPSV SIEADALNPE
430 440 450 460 470 480
QAPTSLQDSI PAEADFLLGL ATVPGYVSFR HVEEGSWYIQ SLCNHLKKLV PRMLKFLEKT
490 500 510 520
MEIRGRKRTV WGAKQISATS LPTAISAQTP RPPMRRWSSV S
10 20 30 40 50 60
MKSQGQHWYS SSDKNCKVSF REKLLIIDSN LGVQDVENLK FLCIGLVPNK KLEKSSSASD
70 80 90 100 110 120
VFEHLLAEDL LSEEDPFFLA ELLYIIRQKK LLQHLNCTKE EVERLLPTRQ RVSLFRNLLY
130 140 150 160 170 180
ELSEGIDSEN LKDMIFLLKD SLPKTEMTSL SFLAFLEKQG KIDEDNLTCL EDLCKTVVPK
190 200 210 220 230 240
LLRNIEKYKR EKAIQIVTPP VDKEAESYQG EEELVSQTDV KTFLEALPQE SWQNKHAGSN
250 260 270 280 290 300
GNRATNGAPS LVSRGMQGAS ANTLNSETST KRAAVYRMNR NHRGLCVIVN NHSFTSLKDR
310 320 330 340 350 360
QGTHKDAEIL SHVFQWLGFT VHIHNNVTKV EMEMVLQKQK CNPAHADGDC FVFCILTHGR
370 380 390 400 410 420
FGAVYSSDEA LIPIREIMSH FTALQCPRLA EKPKLFFIQA CQGEEIQPSV SIEADALNPE
430 440 450 460 470 480
QAPTSLQDSI PAEADFLLGL ATVPGYVSFR HVEEGSWYIQ SLCNHLKKLV PRMLKFLEKT
490 500 510 520
MEIRGRKRTV WGAKQISATS LPTAISAQTP RPPMRRWSSV S
10 20 30 40 50 60
MKSQGQHWYS SSDKNCKVSF REKLLIIDSN LGVQDVENLK FLCIGLVPNK KLEKSSSASD
70 80 90 100 110 120
VFEHLLAEDL LSEEDPFFLA ELLYIIRQKK LLQHLNCTKE EVERLLPTRQ RVSLFRNLLY
130 140 150 160 170 180
ELSEGIDSEN LKDMIFLLKD SLPKTEMTSL SFLAFLEKQG KIDEDNLTCL EDLCKTVVPK
190 200 210 220 230 240
LLRNIEKYKR EKAIQIVTPP VDKEAESYQG EEELVSQTDV KTFLEALPQE SWQNKHAGSN
250 260 270 280 290 300
GNRATNGAPS LVSRGMQGAS ANTLNSETST KRAAVYRMNR NHRGLCVIVN NHSFTSLKDR
310 320 330 340 350 360
QGTHKDAEIL SHVFQWLGFT VHIHNNVTKV EMEMVLQKQK CNPAHADGDC FVFCILTHGR
370 380 390 400 410 420
FGAVYSSDEA LIPIREIMSH FTALQCPRLA EKPKLFFIQA CQGEEIQPSV SIEADALNPE
430 440 450 460 470 480
QAPTSLQDSI PAEADFLLGL ATVPGYVSFR HVEEGSWYIQ SLCNHLKKLV PRMLKFLEKT
490 500 510 520
MEIRGRKRTV WGAKQISATS LPTAISAQTP RPPMRRWSSV S
10 20 30 40 50 60
MKSQGQHWYS SSDKNCKVSF REKLLIIDSN LGVQDVENLK FLCIGLVPNK KLEKSSSASD
70 80 90 100 110 120
VFEHLLAEDL LSEEDPFFLA ELLYIIRQKK LLQHLNCTKE EVERLLPTRQ RVSLFRNLLY
130 140 150 160 170 180
ELSEGIDSEN LKDMIFLLKD SLPKTEMTSL SFLAFLEKQG KIDEDNLTCL EDLCKTVVPK
190 200 210 220 230 240
LLRNIEKYKR EKAIQIVTPP VDKEAESYQG EEELVSQTDV KTFLEALPQE SWQNKHAGSN
250 260 270 280 290 300
GNRATNGAPS LVSRGMQGAS ANTLNSETST KRAAVYRMNR NHRGLCVIVN NHSFTSLKDR
310 320 330 340 350 360
QGTHKDAEIL SHVFQWLGFT VHIHNNVTKV EMEMVLQKQK CNPAHADGDC FVFCILTHGR
370 380 390 400 410 420
FGAVYSSDEA LIPIREIMSH FTALQCPRLA EKPKLFFIQA CQGEEIQPSV SIEADALNPE
430 440 450 460 470 480
QAPTSLQDSI PAEADFLLGL ATVPGYVSFR HVEEGSWYIQ SLCNHLKKLV PRMLKFLEKT
490 500 510 520
MEIRGRKRTV WGAKQISATS LPTAISAQTP RPPMRRWSSV S
10 20 30 40 50 60
MKSQGQHWYS SSDKNCKVSF REKLLIIDSN LGVQDVENLK FLCIGLVPNK KLEKSSSASD
70 80 90 100 110 120
VFEHLLAEDL LSEEDPFFLA ELLYIIRQKK LLQHLNCTKE EVERLLPTRQ RVSLFRNLLY
130 140 150 160 170 180
ELSEGIDSEN LKDMIFLLKD SLPKTEMTSL SFLAFLEKQG KIDEDNLTCL EDLCKTVVPK
190 200 210 220 230 240
LLRNIEKYKR EKAIQIVTPP VDKEAESYQG EEELVSQTDV KTFLEALPQE SWQNKHAGSN
250 260 270 280 290 300
GNRATNGAPS LVSRGMQGAS ANTLNSETST KRAAVYRMNR NHRGLCVIVN NHSFTSLKDR
310 320 330 340 350 360
QGTHKDAEIL SHVFQWLGFT VHIHNNVTKV EMEMVLQKQK CNPAHADGDC FVFCILTHGR
370 380 390 400 410 420
FGAVYSSDEA LIPIREIMSH FTALQCPRLA EKPKLFFIQA CQGEEIQPSV SIEADALNPE
430 440 450 460 470 480
QAPTSLQDSI PAEADFLLGL ATVPGYVSFR HVEEGSWYIQ SLCNHLKKLV PRMLKFLEKT
490 500 510 520
MEIRGRKRTV WGAKQISATS LPTAISAQTP RPPMRRWSSV S
10 20 30 40 50 60
MKSQGQHWYS SSDKNCKVSF REKLLIIDSN LGVQDVENLK FLCIGLVPNK KLEKSSSASD
70 80 90 100 110 120
VFEHLLAEDL LSEEDPFFLA ELLYIIRQKK LLQHLNCTKE EVERLLPTRQ RVSLFRNLLY
130 140 150 160 170 180
ELSEGIDSEN LKDMIFLLKD SLPKTEMTSL SFLAFLEKQG KIDEDNLTCL EDLCKTVVPK
190 200 210 220 230 240
LLRNIEKYKR EKAIQIVTPP VDKEAESYQG EEELVSQTDV KTFLEALPQE SWQNKHAGSN
250 260 270 280 290 300
GNRATNGAPS LVSRGMQGAS ANTLNSETST KRAAVYRMNR NHRGLCVIVN NHSFTSLKDR
310 320 330 340 350 360
QGTHKDAEIL SHVFQWLGFT VHIHNNVTKV EMEMVLQKQK CNPAHADGDC FVFCILTHGR
370 380 390 400 410 420
FGAVYSSDEA LIPIREIMSH FTALQCPRLA EKPKLFFIQA CQGEEIQPSV SIEADALNPE
430 440 450 460 470 480
QAPTSLQDSI PAEADFLLGL ATVPGYVSFR HVEEGSWYIQ SLCNHLKKLV PRMLKFLEKT
490 500 510 520
MEIRGRKRTV WGAKQISATS LPTAISAQTP RPPMRRWSSV S
Protein Neighborhood
Domains & Features
5 N-termini - 3 C-termini - 3 Cleavages - 16 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
Q92851-1-unknown | MKSQGQ... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt69356 | |||
Q92851-1-unknown | MKSQGQ... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt69357 | |||
Q92851-1-unknown | MKSQGQ... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt69358 | |||
Q92851-1-unknown | MKSQGQ... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt69359 | |||
Q92851-1-unknown | MKSQGQ... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt69360 | |||
Q92851-1-unknown | MKSQGQ... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt69361 | |||
Q92851-220-unknown | VKTFLE... | 220 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q92851-220-unknown | VKTFLE... | 220 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC3205 | |||
Q92851-220-unknown | VKTFLE... | 220 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt116049 | |||
Q92851-220-unknown | VKTFLE... | 220 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt116050 | |||
Q92851-220-unknown | VKTFLE... | 220 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt116051 | |||
Q92851-226-unknown | ALPQES... | 226 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt178377 | |||
Q92851-226- | ALPQES... | 226 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
Q92851-416-unknown | ALNPEQ... | 416 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q92851-416-unknown | ALNPEQ... | 416 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC3209 | |||
Q92851-416-unknown | ALNPEQ... | 416 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC13015 | |||
Q92851-416-unknown | ALNPEQ... | 416 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt116205 | |||
Q92851-416-unknown | ALNPEQ... | 416 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt116206 | |||
Q92851-416-unknown | ALNPEQ... | 416 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt116208 | |||
Q92851-416-unknown | ALNPEQ... | 416 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt116207 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...VSQTDV | 219 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC3205 | |||
...VSQTDV | 219 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt130702 | |||
...VSQTDV | 219 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt130703 | |||
...VSQTDV | 219 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt130705 | |||
...VSQTDV | 219 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt155797 | |||
...VSQTDV | 219 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt155798 | |||
...VSQTDV | 219 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt155799 | |||
...SIEADA | 415 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...SIEADA | 415 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC3209 | |||
...SIEADA | 415 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC13015 | |||
...SIEADA | 415 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt92703 | |||
...SIEADA | 415 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt92704 | |||
...SIEADA | 415 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt92706 | |||
...SIEADA | 415 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt92705 | |||
...WSSVS | 521 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...WSSVS | 521 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt64977 |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
CASPA_HUMAN | 219 | QTDV.|.VKTF | inferred from experiment | unknown | MEROPS | Alnemri ES | Srinivasula SM et al.:Molecular ordering of the Fas-a... (C14.009) | 8962078, |
CASPA_HUMAN | 415 | EADA.|.ALNP | inferred from experiment | unknown | MEROPS | Alnemri ES | Srinivasula SM et al.:Molecular ordering of the Fas-a... (C14.009) | 8962078, |
GRAB_HUMAN | 415 | EADA.|.ALNP | inferred from experiment | unknown | MEROPS | Martin SJ | Adrain C et al.:The cytotoxic lymphocyte protea... (S01.010) | 16415351, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
CASP3_HUMAN | 9 | SVDS.|.SKSI | inferred from experiment | unknown | MEROPS | Alnemri ES | Fernandes-Alnemri T et al.:In vitro activation of CPP32 an... (C14.011) | 8755496, |
GATA1-Isoform3_HUMAN | 42 | DLDG.|.GKGS | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC3199 | ||
GATA1_HUMAN | 125 | DLDG.|.GKGS | inferred from experiment | unknown | MEROPS | Peschle C | De Maria R et al.:Negative regulation of erythrop... (C14.003) | 10519553, |
GATA1-Isoform2_HUMAN | 125 | DLDG.|.GKGS | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC3199 | ||
CASP3_HUMAN | 175 | ETDS.|.SGVD | inferred from experiment | unknown | MEROPS | Alnemri ES | Fernandes-Alnemri T et al.:In vitro activation of CPP32 an... (C14.011) | 8755496, |
CASPA_HUMAN | 219 | QTDV.|.VKTF | inferred from experiment | unknown | MEROPS | Alnemri ES | Srinivasula SM et al.:Molecular ordering of the Fas-a... (C14.009) | 8962078, |
CASPA-Isoform6_HUMAN | 219 | QTDV.|.VKTF | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC3205 | ||
CASPA-Isoform3_HUMAN | 219 | QTDV.|.VKTF | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC3205 | ||
CASPA-Isoform4_HUMAN | 219 | QTDV.|.VKTF | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC3205 | ||
IF2A_HUMAN | 301 | EVDG.|.GDDD | inferred from experiment | unknown | MEROPS | Shimotohno K | Satoh S et al.:Caspase-mediated cleavage of eu... (C14.003) | 10432301, |
CASPA-Isoform6_HUMAN | 348 | EADA.|.ALNP | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC3209 | ||
CASPA-Isoform5_HUMAN | 372 | EADA.|.ALNP | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC3209 | ||
CASPA-Isoform2_HUMAN | 372 | EADA.|.ALNP | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC3209 | ||
CASPA_HUMAN | 415 | EADA.|.ALNP | inferred from experiment | unknown | MEROPS | Alnemri ES | Srinivasula SM et al.:Molecular ordering of the Fas-a... (C14.009) | 8962078, |
CASPA-Isoform4_HUMAN | 415 | EADA.|.ALNP | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC3209 | ||
AKAP1_HUMAN | 582 | SVDS.|.SCCS | inferred from experiment | unknown | MEROPS | Ahn SK | Yoo H et al.:Specific proteolysis of the A-k... (C14.006) | 18497968, |