P05198: Eukaryotic translation initiation factor 2 subunit 1

General Information

Protein names	- Eukaryotic translation initiation factor 2 subunit 1 - Eukaryotic translation initiation factor 2 subunit alpha - eIF-2-alpha - eIF-2A - eIF-2alpha
Gene names	EIF2S1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P05198

6 N-termini

6 C-termini

8 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPGLSCRFYQ HKFPEVEDVV MVNVRSIAEM GAYVSLLEYN NIEGMILLSE LSRRRIRSIN
        70         80         90        100        110        120
KLIRIGRNEC VVVIRVDKEK GYIDLSKRRV SPEEAIKCED KFTKSKTVYS ILRHVAEVLE
       130        140        150        160        170        180
YTKDEQLESL FQRTAWVFDD KYKRPGYGAY DAFKHAVSDP SILDSLDLNE DEREVLINNI
       190        200        210        220        230        240
NRRLTPQAVK IRADIEVACY GYEGIDAVKE ALRAGLNCST ENMPIKINLI APPRYVMTTT
       250        260        270        280        290        300
TLERTEGLSV LSQAMAVIKE KIEEKRGVFN VQMEPKVVTD TDETELARQM ERLERENAEV
       310
DGDDDAEEME AKAED

Isoforms

Sequence View

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P05198-1-unknown	MPGLSC...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P05198-2-unknown	PGLSCR...	2		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P05198-2-unknown	PGLSCR...	2		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P05198-256-unknown	AVIKEK...	256	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18479
P05198-256-unknown	AVIKEK...	256	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17117
P05198-274-unknown	EPKVVT...	274	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17118
P05198-302-unknown	GDDDAE...	302	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1562
P05198-302-unknown	GDDDAE...	302	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3198
P05198-302-unknown	GDDDAE...	302	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2457
P05198-302-unknown	GDDDAE...	302	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3028
P05198-305-unknown	DAEEME...	305	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1563

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...LSQAMA	255	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18479
...LSQAMA	255	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17117
...VFNVQM	272	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000451975
...VFNVQM	272	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17118
...NAEVDG	301	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1562
...NAEVDG	301	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3198
...NAEVDG	301	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2457
...NAEVDG	301	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3028
...VDGDDD	304	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1563
...AKAED	315		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...AKAED	315		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...AKAED	315	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...AKAED	315		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...AKAED	315		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	255	QAMA.\|.AVIK	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	255	QAMA.\|.AVIK	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	273	VQME.\|.EPKV	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CASP3_HUMAN	301	EVDG.\|.GDDD	inferred from experiment	unknown	MEROPS	Shimotohno K	Satoh S et al.:Caspase-mediated cleavage of eu... (C14.003)	10432301,
CASPA_HUMAN	301	EVDG.\|.GDDD	inferred from experiment	unknown	MEROPS	Shimotohno K	Satoh S et al.:Caspase-mediated cleavage of eu... (C14.003)	10432301,
CASP6_HUMAN	301	EVDG.\|.GDDD	inferred from experiment	unknown	MEROPS		Merops CASP6_HUMAN -> IF2A_HUMAN @301
CASP8_HUMAN	301	EVDG.\|.GDDD	inferred from experiment	unknown	MEROPS		Merops CASP8_HUMAN -> IF2A_HUMAN @301
CASP3_HUMAN	304	GDDD.\|.DAEE	inferred from experiment	unknown	MEROPS	Shimotohno K	Satoh S et al.:Caspase-mediated cleavage of eu... (C14.003)	10432301,

TopFIND

P05198: Eukaryotic translation initiation factor 2 subunit 1

General Information

6

N-termini

6

C-termini

8

Cleavages

0

Substrates

Sequence

Isoforms

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Protein Neighborhood

Domains & Features

6 N-termini - 6 C-termini - 8 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates