P06400: Retinoblastoma-associated protein

General Information

Protein names	- Retinoblastoma-associated protein - p105-Rb - pRb - Rb - pp110
Gene names	RB1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P06400

9 N-termini

7 C-termini

9 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPPKTPRKTA ATAAAAAAEP PAPPPPPPPE EDPEQDSGPE DLPLVRLEFE ETEEPDFTAL
        70         80         90        100        110        120
CQKLKIPDHV RERAWLTWEK VSSVDGVLGG YIQKKKELWG ICIFIAAVDL DEMSFTFTEL
       130        140        150        160        170        180
QKNIEISVHK FFNLLKEIDT STKVDNAMSR LLKKYDVLFA LFSKLERTCE LIYLTQPSSS
       190        200        210        220        230        240
ISTEINSALV LKVSWITFLL AKGEVLQMED DLVISFQLML CVLDYFIKLS PPMLLKEPYK
       250        260        270        280        290        300
TAVIPINGSP RTPRRGQNRS ARIAKQLEND TRIIEVLCKE HECNIDEVKN VYFKNFIPFM
       310        320        330        340        350        360
NSLGLVTSNG LPEVENLSKR YEEIYLKNKD LDARLFLDHD KTLQTDSIDS FETQRTPRKS
       370        380        390        400        410        420
NLDEEVNVIP PHTPVRTVMN TIQQLMMILN SASDQPSENL ISYFNNCTVN PKESILKRVK
       430        440        450        460        470        480
DIGYIFKEKF AKAVGQGCVE IGSQRYKLGV RLYYRVMESM LKSEEERLSI QNFSKLLNDN
       490        500        510        520        530        540
IFHMSLLACA LEVVMATYSR STSQNLDSGT DLSFPWILNV LNLKAFDFYK VIESFIKAEG
       550        560        570        580        590        600
NLTREMIKHL ERCEHRIMES LAWLSDSPLF DLIKQSKDRE GPTDHLESAC PLNLPLQNNH
       610        620        630        640        650        660
TAADMYLSPV RSPKKKGSTT RVNSTANAET QATSAFQTQK PLKSTSLSLF YKKVYRLAYL
       670        680        690        700        710        720
RLNTLCERLL SEHPELEHII WTLFQHTLQN EYELMRDRHL DQIMMCSMYG ICKVKNIDLK
       730        740        750        760        770        780
FKIIVTAYKD LPHAVQETFK RVLIKEEEYD SIIVFYNSVF MQRLKTNILQ YASTRPPTLS
       790        800        810        820        830        840
PIPHIPRSPY KFPSSPLRIP GGNIYISPLK SPYKISEGLP TPTKMTPRSR ILVSIGESFG
       850        860        870        880        890        900
TSEKFQKINQ MVCNSDRVLK RSAEGSNPPK PLKKLRFDIE GSDEADGSKH LPGESKFQQK
       910        920
LAEMTSTRTR MQKQKMNDSM DTSNKEEK

Isoforms

Sequence View

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Directness:

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Evidence Codes:

Methodology:

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

9 N-termini - 7 C-termini - 9 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P06400-2-unknown	PPKTPR...	2	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P06400-2-unknown	PPKTPR...	2	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P06400-17-	AAEPPA...	17		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P06400-37-unknown	SGPEDL...	37	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11054
P06400-271-unknown	TRIIEV...	271	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3183
P06400-347-	SIDSFE...	347		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P06400-347-	SIDSFE...	347		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P06400-347-	SIDSFE...	347		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P06400-347-	SIDSFE...	347		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P06400-347-unknown	SIDSFE...	347		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P06400-350-unknown	SFETQR...	350	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1573
P06400-350-unknown	SFETQR...	350	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3029
P06400-350-unknown	SFETQR...	350	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2794
P06400-811-unknown	SPYKIS...	811	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC928
P06400-887-unknown	GSKHLP...	887	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1574
P06400-887-unknown	GSKHLP...	887	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1361
P06400-887-unknown	GSKHLP...	887	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2795

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...DPEQDS	36	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11054
...QLENDT	270	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3183
...TDSIDS	349	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1573
...TDSIDS	349	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3029
...TDSIDS	349	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2794
...ISPLKS	810	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC928
...SDEADG	886	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1574
...SDEADG	886	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1361
...SDEADG	886	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2795
...NKEEK	928		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...NKEEK	928		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...NKEEK	928	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...NKEEK	928		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...NKEEK	928		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	36	EQDS.\|.SGPE	inferred from experiment	unknown	MEROPS		Merops GRAB_HUMAN -> RB_HUMAN @36
GRAB_HUMAN	36	EQDS.\|.SGPE	inferred from experiment	unknown	MEROPS	Gevaert K	Plasman K et al.:Probing the efficiency of prote... (S01.010)	21048194,
CASP9_HUMAN	270	ENDT.\|.TRII	inferred from experiment	unknown	MEROPS	Vayssiere JL	Lemaire C et al.:Caspase-9 can antagonize p53-in... (C14.006)	15735701,
CASP3_HUMAN	349	SIDS.\|.SFET	inferred from experiment	unknown	MEROPS	Johnson DE	Fattman CL et al.:Sequential two-step cleavage of... (C14.003)	11420704,
CASP8_HUMAN	349	SIDS.\|.SFET	inferred from experiment	unknown	MEROPS	Vayssiere JL	Lemaire C et al.:Caspase-9 can antagonize p53-in... (C14.006)	15735701,
CASP7_HUMAN	349	SIDS.\|.SFET	inferred from experiment	unknown	MEROPS	Johnson DE	Fattman CL et al.:Sequential two-step cleavage of... (C14.003)	11420704,
CAN2_HUMAN	810	PLKS.\|.SPYK	inferred from experiment	unknown	MEROPS	Suhrbier A	Darnell GA et al.:Human papillomavirus E7 require... (C02.002)	17977825,
CASP3_HUMAN	886	EADG.\|.GSKH	inferred from experiment	unknown	MEROPS	Vayssiere JL	Lemaire C et al.:Caspase-9 can antagonize p53-in... (C14.006)	15735701,
CASP2_HUMAN	886	EADG.\|.GSKH	inferred from experiment	unknown	MEROPS	Vayssiere JL	Lemaire C et al.:Caspase-9 can antagonize p53-in... (C14.006)	15735701,
CASP7_HUMAN	886	EADG.\|.GSKH	inferred from experiment	unknown	MEROPS	Vayssiere JL	Lemaire C et al.:Caspase-9 can antagonize p53-in... (C14.006)	15735701,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)