TopFIND 4.0

P42575: Caspase-2

General Information

Protein names
- Caspase-2
- CASP-2
- 3.4.22.55
- Neural precursor cell expressed developmentally down-regulated protein 2
- NEDD-2
- Protease ICH-1
- Caspase-2 subunit p18
- Caspase-2 subunit p13
- Caspase-2 subunit p12
Gene names CASP2
Organism Homo sapiens
Protease Family C14.006
Protease ID C14.006
Chromosome location
UniProt ID P42575

6

N-termini

3

C-termini

1

Cleavages

15

Substrates

Sequence

        10         20         30         40         50         60 
MAAPSAGSWS TFQHKELMAA DRGRRILGVC GMHPHHQETL KKNRVVLAKQ LLLSELLEHL 
        70         80         90        100        110        120 
LEKDIITLEM RELIQAKVGS FSQNVELLNL LPKRGPQAFD AFCEALRETK QGHLEDMLLT 
       130        140        150        160        170        180 
TLSGLQHVLP PLSCDYDLSL PFPVCESCPL YKKLRLSTDT VEHSLDNKDG PVCLQVKPCT 
       190        200        210        220        230        240 
PEFYQTHFQL AYRLQSRPRG LALVLSNVHF TGEKELEFRS GGDVDHSTLV TLFKLLGYDV 
       250        260        270        280        290        300 
HVLCDQTAQE MQEKLQNFAQ LPAHRVTDSC IVALLSHGVE GAIYGVDGKL LQLQEVFQLF 
       310        320        330        340        350        360 
DNANCPSLQN KPKMFFIQAC RGDETDRGVD QQDGKNHAGS PGCEESDAGK EKLPKMRLPT 
       370        380        390        400        410        420 
RSDMICGYAC LKGTAAMRNT KRGSWYIEAL AQVFSERACD MHVADMLVKV NALIKDREGY 
       430        440        450    
APGTEFHRCK EMSEYCSTLC RHLYLFPGHP PT

Isoforms

- Isoform 2 of Caspase-2 - Isoform 3 of Caspase-2

Sequence View

        10         20         30         40         50         60 
MAAPSAGSWS TFQHKELMAA DRGRRILGVC GMHPHHQETL KKNRVVLAKQ LLLSELLEHL 
        70         80         90        100        110        120 
LEKDIITLEM RELIQAKVGS FSQNVELLNL LPKRGPQAFD AFCEALRETK QGHLEDMLLT 
       130        140        150        160        170        180 
TLSGLQHVLP PLSCDYDLSL PFPVCESCPL YKKLRLSTDT VEHSLDNKDG PVCLQVKPCT 
       190        200        210        220        230        240 
PEFYQTHFQL AYRLQSRPRG LALVLSNVHF TGEKELEFRS GGDVDHSTLV TLFKLLGYDV 
       250        260        270        280        290        300 
HVLCDQTAQE MQEKLQNFAQ LPAHRVTDSC IVALLSHGVE GAIYGVDGKL LQLQEVFQLF 
       310        320        330        340        350        360 
DNANCPSLQN KPKMFFIQAC RGDETDRGVD QQDGKNHAGS PGCEESDAGK EKLPKMRLPT 
       370        380        390        400        410        420 
RSDMICGYAC LKGTAAMRNT KRGSWYIEAL AQVFSERACD MHVADMLVKV NALIKDREGY 
       430        440        450    
APGTEFHRCK EMSEYCSTLC RHLYLFPGHP PT         10         20         30         40         50         60 
MAAPSAGSWS TFQHKELMAA DRGRRILGVC GMHPHHQETL KKNRVVLAKQ LLLSELLEHL 
        70         80         90        100        110        120 
LEKDIITLEM RELIQAKVGS FSQNVELLNL LPKRGPQAFD AFCEALRETK QGHLEDMLLT 
       130        140        150        160        170        180 
TLSGLQHVLP PLSCDYDLSL PFPVCESCPL YKKLRLSTDT VEHSLDNKDG PVCLQVKPCT 
       190        200        210        220        230        240 
PEFYQTHFQL AYRLQSRPRG LALVLSNVHF TGEKELEFRS GGDVDHSTLV TLFKLLGYDV 
       250        260        270        280        290        300 
HVLCDQTAQE MQEKLQNFAQ LPAHRVTDSC IVALLSHGVE GAIYGVDGKL LQLQEVFQLF 
       310        320        330        340        350        360 
DNANCPSLQN KPKMFFIQAC RGDETDRGVD QQDGKNHAGS PGCEESDAGK EKLPKMRLPT 
       370        380        390        400        410        420 
RSDMICGYAC LKGTAAMRNT KRGSWYIEAL AQVFSERACD MHVADMLVKV NALIKDREGY 
       430        440        450    
APGTEFHRCK EMSEYCSTLC RHLYLFPGHP PT



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Protein Neighborhood

Domains & Features

6 N-termini - 3 C-termini - 1 Cleavages - 15 Substrates

N-termini

C-termini

Cleavages

Substrates