P56524: Histone deacetylase 4

General Information

Protein names	- Histone deacetylase 4 - HD4 - 3.5.1.98
Gene names	HDAC4
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P56524

7 N-termini

6 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSSQSHPDGL SGRDQPVELL NPARVNHMPS TVDVATALPL QVAPSAVPMD LRLDHQFSLP
        70         80         90        100        110        120
VAEPALREQQ LQQELLALKQ KQQIQRQILI AEFQRQHEQL SRQHEAQLHE HIKQQQEMLA
       130        140        150        160        170        180
MKHQQELLEH QRKLERHRQE QELEKQHREQ KLQQLKNKEK GKESAVASTE VKMKLQEFVL
       190        200        210        220        230        240
NKKKALAHRN LNHCISSDPR YWYGKTQHSS LDQSSPPQSG VSTSYNHPVL GMYDAKDDFP
       250        260        270        280        290        300
LRKTASEPNL KLRSRLKQKV AERRSSPLLR RKDGPVVTAL KKRPLDVTDS ACSSAPGSGP
       310        320        330        340        350        360
SSPNNSSGSV SAENGIAPAV PSIPAETSLA HRLVAREGSA APLPLYTSPS LPNITLGLPA
       370        380        390        400        410        420
TGPSAGTAGQ QDAERLTLPA LQQRLSLFPG THLTPYLSTS PLERDGGAAH SPLLQHMVLL
       430        440        450        460        470        480
EQPPAQAPLV TGLGALPLHA QSLVGADRVS PSIHKLRQHR PLGRTQSAPL PQNAQALQHL
       490        500        510        520        530        540
VIQQQHQQFL EKHKQQFQQQ QLQMNKIIPK PSEPARQPES HPEETEEELR EHQALLDEPY
       550        560        570        580        590        600
LDRLPGQKEA HAQAGVQVKQ EPIESDEEEA EPPREVEPGQ RQPSEQELLF RQQALLLEQQ
       610        620        630        640        650        660
RIHQLRNYQA SMEAAGIPVS FGGHRPLSRA QSSPASATFP VSVQEPPTKP RFTTGLVYDT
       670        680        690        700        710        720
LMLKHQCTCG SSSSHPEHAG RIQSIWSRLQ ETGLRGKCEC IRGRKATLEE LQTVHSEAHT
       730        740        750        760        770        780
LLYGTNPLNR QKLDSKKLLG SLASVFVRLP CGGVGVDSDT IWNEVHSAGA ARLAVGCVVE
       790        800        810        820        830        840
LVFKVATGEL KNGFAVVRPP GHHAEESTPM GFCYFNSVAV AAKLLQQRLS VSKILIVDWD
       850        860        870        880        890        900
VHHGNGTQQA FYSDPSVLYM SLHRYDDGNF FPGSGAPDEV GTGPGVGFNV NMAFTGGLDP
       910        920        930        940        950        960
PMGDAEYLAA FRTVVMPIAS EFAPDVVLVS SGFDAVEGHP TPLGGYNLSA RCFGYLTKQL
       970        980        990       1000       1010       1020
MGLAGGRIVL ALEGGHDLTA ICDASEACVS ALLGNELDPL PEKVLQQRPN ANAVRSMEKV
      1030       1040       1050       1060       1070       1080
MEIHSKYWRC LQRTTSTAGR SLIEAQTCEN EEAETVTAMA SLSVGVKPAE KRPDEEPMEE

EPPL

Isoforms

- Isoform 2 of Histone deacetylase 4

Sequence View

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Protein Neighborhood

Domains & Features

7 N-termini - 6 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P56524-1-unknown	MSSQSH...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P56524-9-	GLSGRD...	9		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P56524-9-	GLSGRD...	9		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P56524-28-unknown	MPSTVD...	28	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000392912
P56524-34-	VATALP...	34		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P56524-34-	VATALP...	34		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P56524-232-	MYDAKD...	232		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P56524-290-unknown	SACSSA...	290	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1365
P56524-290-unknown	SACSSA...	290	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1937
P56524-417-unknown	MVLLEQ...	417	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000440481

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VNHMPS	29	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000438111
...QHREQK	150	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000392912
...RNLNHC	193	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000405226
...LDVTDS	289	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1365
...LDVTDS	289	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1937
...SPLERD	404	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000391226
...EEPPL	1084	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP2_HUMAN	289	VTDS.\|.SACS	inferred from experiment	unknown	MEROPS	Brancolini C	Paroni G et al.:Caspase-dependent regulation of... (C14.006)	15075374,
CASP3_HUMAN	289	VTDS.\|.SACS	inferred from experiment	unknown	MEROPS	Brancolini C	Paroni G et al.:Caspase-dependent regulation of... (C14.006)	15075374,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)