P04049: RAF proto-oncogene serine/threonine-protein kinase

General Information

Protein names	- RAF proto-oncogene serine/threonine-protein kinase - 2.7.11.1 - Proto-oncogene c-RAF - cRaf - Raf-1
Gene names	RAF1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P04049

3 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MEHIQGAWKT ISNGFGFKDA VFDGSSCISP TIVQQFGYQR RASDDGKLTD PSKTSNTIRV
        70         80         90        100        110        120
FLPNKQRTVV NVRNGMSLHD CLMKALKVRG LQPECCAVFR LLHEHKGKKA RLDWNTDAAS
       130        140        150        160        170        180
LIGEELQVDF LDHVPLTTHN FARKTFLKLA FCDICQKFLL NGFRCQTCGY KFHEHCSTKV
       190        200        210        220        230        240
PTMCVDWSNI RQLLLFPNST IGDSGVPALP SLTMRRMRES VSRMPVSSQH RYSTPHAFTF
       250        260        270        280        290        300
NTSSPSSEGS LSQRQRSTST PNVHMVSTTL PVDSRMIEDA IRSHSESASP SALSSSPNNL
       310        320        330        340        350        360
SPTGWSQPKT PVPAQRERAP VSGTQEKNKI RPRGQRDSSY YWEIEASEVM LSTRIGSGSF
       370        380        390        400        410        420
GTVYKGKWHG DVAVKILKVV DPTPEQFQAF RNEVAVLRKT RHVNILLFMG YMTKDNLAIV
       430        440        450        460        470        480
TQWCEGSSLY KHLHVQETKF QMFQLIDIAR QTAQGMDYLH AKNIIHRDMK SNNIFLHEGL
       490        500        510        520        530        540
TVKIGDFGLA TVKSRWSGSQ QVEQPTGSVL WMAPEVIRMQ DNNPFSFQSD VYSYGIVLYE
       550        560        570        580        590        600
LMTGELPYSH INNRDQIIFM VGRGYASPDL SKLYKNCPKA MKRLVADCVK KVKEERPLFP
       610        620        630        640
QILSSIELLQ HSLPKINRSA SEPSLHRAAH TEDINACTLT TSPRLPVF

Isoforms

- Isoform 2 of RAF proto-oncogene serine/threonine-protein kinase

Sequence View

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Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P04049-1-unknown	MEHIQG...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P04049-1-unknown	MEHIQG...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt86920
P04049-265-	MVSTTL...	265		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P04049-280-unknown	AIRSHS...	280	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3182
P04049-280-unknown	AIRSHS...	280	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt198685

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RMIEDA	279	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3182
...RLPVF	648	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...RLPVF	648	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt82538

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP9_HUMAN	279	IEDA.\|.AIRS	inferred from experiment	unknown	MEROPS	Beyaert R	Cornelis S et al.:Apoptosis of hematopoietic cell... (C14.010)	15674327,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)