Q02156: Protein kinase C epsilon type

General Information

Protein names	- Protein kinase C epsilon type - 2.7.11.13 - nPKC-epsilon
Gene names	PRKCE
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q02156

4 N-termini

4 C-termini

6 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MVVFNGLLKI KICEAVSLKP TAWSLRHAVG PRPQTFLLDP YIALNVDDSR IGQTATKQKT
        70         80         90        100        110        120
NSPAWHDEFV TDVCNGRKIE LAVFHDAPIG YDDFVANCTI QFEELLQNGS RHFEDWIDLE
       130        140        150        160        170        180
PEGRVYVIID LSGSSGEAPK DNEERVFRER MRPRKRQGAV RRRVHQVNGH KFMATYLRQP
       190        200        210        220        230        240
TYCSHCRDFI WGVIGKQGYQ CQVCTCVVHK RCHELIITKC AGLKKQETPD QVGSQRFSVN
       250        260        270        280        290        300
MPHKFGIHNY KVPTFCDHCG SLLWGLLRQG LQCKVCKMNV HRRCETNVAP NCGVDARGIA
       310        320        330        340        350        360
KVLADLGVTP DKITNSGQRR KKLIAGAESP QPASGSSPSE EDRSKSAPTS PCDQEIKELE
       370        380        390        400        410        420
NNIRKALSFD NRGEEHRAAS SPDGQLMSPG ENGEVRQGQA KRLGLDEFNF IKVLGKGSFG
       430        440        450        460        470        480
KVMLAELKGK DEVYAVKVLK KDVILQDDDV DCTMTEKRIL ALARKHPYLT QLYCCFQTKD
       490        500        510        520        530        540
RLFFVMEYVN GGDLMFQIQR SRKFDEPRSR FYAAEVTSAL MFLHQHGVIY RDLKLDNILL
       550        560        570        580        590        600
DAEGHCKLAD FGMCKEGILN GVTTTTFCGT PDYIAPEILQ ELEYGPSVDW WALGVLMYEM
       610        620        630        640        650        660
MAGQPPFEAD NEDDLFESIL HDDVLYPVWL SKEAVSILKA FMTKNPHKRL GCVASQNGED
       670        680        690        700        710        720
AIKQHPFFKE IDWVLLEQKK IKPPFKPRIK TKRDVNNFDQ DFTREEPVLT LVDEAIVKQI
       730
NQEEFKGFSY FGEDLMP

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

4 N-termini - 4 C-termini - 6 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q02156-1-unknown	MVVFNG...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q02156-278-unknown	MNVHRR...	278	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000378341
Q02156-384-unknown	GQLMSP...	384	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2926
Q02156-384-unknown	GQLMSP...	384	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3193
Q02156-384-unknown	GQLMSP...	384	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2036
Q02156-452-unknown	CTMTEK...	452	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2927
Q02156-452-unknown	CTMTEK...	452	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3194
Q02156-452-unknown	CTMTEK...	452	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2037

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GRVYVI	127	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000394574
...ASSPDG	383	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2926
...ASSPDG	383	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3193
...ASSPDG	383	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2036
...DDDVDC	451	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2927
...DDDVDC	451	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3194
...DDDVDC	451	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2037
...EDLMP	737	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP7_HUMAN	383	SPDG.\|.GQLM	inferred from experiment	unknown	MEROPS		Merops CASP7_HUMAN -> KPCE_HUMAN @383
CASP7_HUMAN	383	SPDG.\|.GQLM	inferred from experiment	unknown	MEROPS	Huang J	Basu A et al.:Proteolytic activation of prote... (C14.003)	12198125,
CASP9_HUMAN	383	SPDG.\|.GQLM	inferred from experiment	unknown	MEROPS		Merops CASP9_HUMAN -> KPCE_HUMAN @383
CASP9_HUMAN	383	SPDG.\|.GQLM	inferred from experiment	unknown	MEROPS	Huang J	Basu A et al.:Proteolytic activation of prote... (C14.003)	12198125,
CASP3_HUMAN	383	SPDG.\|.GQLM	inferred from experiment	unknown	MEROPS		Merops CASP3_HUMAN -> KPCE_HUMAN @383
CASP3_HUMAN	383	SPDG.\|.GQLM	inferred from experiment	unknown	MEROPS	Huang J	Basu A et al.:Proteolytic activation of prote... (C14.003)	12198125,
CASP7_HUMAN	451	DVDC.\|.CTMT	inferred from experiment	unknown	MEROPS		Merops CASP7_HUMAN -> KPCE_HUMAN @451
CASP7_HUMAN	451	DVDC.\|.CTMT	inferred from experiment	unknown	MEROPS	Huang J	Basu A et al.:Proteolytic activation of prote... (C14.003)	12198125,
CASP9_HUMAN	451	DVDC.\|.CTMT	inferred from experiment	unknown	MEROPS		Merops CASP9_HUMAN -> KPCE_HUMAN @451
CASP9_HUMAN	451	DVDC.\|.CTMT	inferred from experiment	unknown	MEROPS	Huang J	Basu A et al.:Proteolytic activation of prote... (C14.003)	12198125,
CASP3_HUMAN	451	DVDC.\|.CTMT	inferred from experiment	unknown	MEROPS		Merops CASP3_HUMAN -> KPCE_HUMAN @451
CASP3_HUMAN	451	DVDC.\|.CTMT	inferred from experiment	unknown	MEROPS	Huang J	Basu A et al.:Proteolytic activation of prote... (C14.003)	12198125,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)